Zhang Q, Zhao Y, Cheng GY. Effect of negative mood, serum inflammatory factors, miR-155, and brain-derived neurotrophic factor. World J Psychiatry 2025; 15(2): 99573 [DOI: 10.5498/wjp.v15.i2.99573]
Corresponding Author of This Article
Guang-Yu Cheng, Traditional Chinese Medicine Translational Medicine Research Center, First Affiliated Hospital Heilongjiang University of Chinese Medicine, No. 26 Heping Road, Xiangfang District, Harbin 150040, Heilongjiang Province, China. chengguangyu@hljucm.edu.cn
Research Domain of This Article
Psychology
Article-Type of This Article
Clinical Trials Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Feb 19, 2025; 15(2): 99573 Published online Feb 19, 2025. doi: 10.5498/wjp.v15.i2.99573
Effect of negative mood, serum inflammatory factors, miR-155, and brain-derived neurotrophic factor
Qi Zhang, Yue Zhao, Guang-Yu Cheng
Qi Zhang, Prevention and Treatment Center, First Affiliated Hospital Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang Province, China
Yue Zhao, Department of Medical, First Affiliated Hospital Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang Province, China
Guang-Yu Cheng, Traditional Chinese Medicine Translational Medicine Research Center, First Affiliated Hospital Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang Province, China
Author contributions: Zhang Q designed the study; Zhang Q, Zhao Y, and Cheng GY analyzed the data; Zhang Q were involved in the data and writing of this article. All authors have read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of the First Affiliated Hospital Heilongjiang University of Chinese Medicine.
Clinical trial registration statement: The study was registered at the Clinical Trial Center (http://www.researchregistry.com) with registration number: Researchregistry10876.
Informed consent statement: All study participants and their legal guardians provided written informed consent prior to study enrolment.
Conflict-of-interest statement: The authors report no relevant conflicts of interest.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guang-Yu Cheng, Traditional Chinese Medicine Translational Medicine Research Center, First Affiliated Hospital Heilongjiang University of Chinese Medicine, No. 26 Heping Road, Xiangfang District, Harbin 150040, Heilongjiang Province, China. chengguangyu@hljucm.edu.cn
Received: October 31, 2024 Revised: November 29, 2024 Accepted: December 19, 2024 Published online: February 19, 2025 Processing time: 75 Days and 0.3 Hours
Abstract
BACKGROUND
Abdominal postoperative patients are susceptible to postoperative depression resulting from pain and stress, which can hinder their rehabilitation. Acupuncture has shown potential to relieve this condition.
AIM
To analyze the mechanism by which acupuncture relieves postoperative depression in patients post-abdominal surgery.
METHODS
Abdominal postoperative patients with depression between January 2015 and December 2023 at the First Affiliated Hospital of Heilongjiang University of Chinese Medicine were enrolled. Patients were divided into two groups using the random throwing method: Observation (250 cases, fluoxetine hydrochloride + acupuncture treatment) and control (250 cases, fluoxetine hydrochloride treatment). Changes in negative emotions Hamilton Depression Scale 24, serum inflammatory factors [tumor necrosis factor α, interleukin (IL)-1β, IL-6], miR-155 expression levels, and BDNF levels were assessed.
RESULTS
Significant improvements were observed in the observation group compared to the control group in all assessed parameters after six weeks (P < 0.05). This suggests that the combination of fluoxetine hydrochloride and acupuncture may be more effective in managing postoperative depression than medication alone.
CONCLUSION
Acupuncture complies with the principle of traditional Chinese medicine syndrome differentiation and ensures the pertinence and effectiveness of treatment. In addition, it not only actively improves depressive symptoms but also effectively regulates the serum level of inflammatory factors.
Core Tip: Syndrome differentiation acupuncture helps to reduce negative mood disorders, inhibit the inflammatory response, downregulate the expression of miR-155, enhance BDNF levels, and promote the rehabilitation process of patients with postoperative depression.
