Published online Feb 19, 2025. doi: 10.5498/wjp.v15.i2.99008
Revised: November 27, 2024
Accepted: December 17, 2024
Published online: February 19, 2025
Processing time: 95 Days and 0.9 Hours
Body composition analysis (BCA) is primarily used in the management of conditions such as obesity and endocrine disorders. However, its potential in providing nutritional guidance for patients with Alzheimer’s disease (AD) remains relatively unexplored.
To explore the clinical efficacy of BCA-based dietary nutrition scheme on bone metabolism in AD patients.
This retrospective study included 96 patients with AD complicated by osteo
No significant differences were observed between groups in terms of age, sex, height, BMI, or other baseline data (P > 0.05). In both groups, BMI did not show significant changes after the intervention (P > 0.05), whereas muscle mass and mineral content were significantly increased (P < 0.05). After the intervention, BMI in the PN group did not differ significantly from that of the RD group, but muscle mass and mineral content were significantly higher in the PN group (P < 0.05). After the intervention, a higher proportion of patients in the PN group had a T score > -1 compared to the RD group (P < 0.05). The mini-mental state examination (MMSE) score was similar in both groups before the intervention. However, 12 weeks after the intervention, the MMSE score in the PN group was significantly higher than that in the RD group (P < 0.05). In both groups, the MMSE score significantly increased 12 weeks post-intervention compared to pre-intervention levels (P < 0.05). Before the intervention, the levels of osteocalcin, serum calcium, PINP, β-CTX, and 25-hydroxyvitamin D were not significantly different between the two groups (P > 0.05). After 12 weeks of intervention, the PN group exhibited higher levels of osteocalcin, serum calcium, and 25-hydroxyvitamin D, as well as lower levels of PINP and β-CTX, compared to the RD group (P < 0.05). In both groups, osteocalcin, serum calcium, and 25-hydroxyvitamin D levels were significantly higher, while PINP and β-CTX levels were significantly lower after 12 weeks of intervention compared to baseline (P < 0.05).
The human BCA-based dietary nutrition regimen plays a crucial role in improving BMD and bone metabolism, with effects that surpass those of conventional nutrition strategies. The findings of this study provide strong evidence for the nutritional management of AD patients.
Core Tip: Body composition analysis (BCA) is primarily used in the management of conditions such as obesity and endocrine disorders. However, its potential in providing nutritional guidance for patients with Alzheimer’s disease (AD) remains relatively unexplored. In this study, we found that both routine diet (RD) and personalized nutritional (PN) interventions significantly increased bone mineral density (BMD) and improved bone metabolism indexes in AD patients compared to baseline levels. Furthermore, PN intervention, which is based on human BCA, provided superior bone outcomes compared to RD, as evidenced by higher BMD and better bone metabolic indexes in the PN group. These findings provide strong research evidence supporting the development of targeted nutritional interventions for AD patients.