Published online Aug 19, 2024. doi: 10.5498/wjp.v14.i8.1190
Revised: July 3, 2024
Accepted: July 12, 2024
Published online: August 19, 2024
Processing time: 82 Days and 19 Hours
The aging of the population has become increasingly obvious in recent years, and the incidence of cerebral infarction has shown an increasing trend annually, with high death and disability rates.
To analyze the effects of infarct location and volume on cognitive dysfunction in elderly patients with acute insular cerebral infarction.
Between January 2020 and December 2023, we treated 98 cases of elderly acute insula, patients with cerebral infarction in the cerebral infarction acute phase (3-4 weeks) and for the course of 6 months in Montreal Cognitive Assessment Scale (MoCA) for screening of cognition. Notably, 58 and 40 patients were placed in the cognitive impairment group and without-cognitive impairment group, respec
The number of patients with cognitive impairment in the basal ganglia and thalamus was significantly higher than that without cognitive impairment (P < 0.05). The total infarct volume in the cognitive impairment group was higher than that in the non-cognitive impairment group, and the difference was statistically significant (P < 0.05). The infarct volumes at different sites in the cognitive impairment group was higher than in the non-cognitive impairment group (P < 0.05). In the cognitive impairment group, the infarct volumes in the basal ganglia, thalamus, and mixed lesions were negatively correlated with the total MoCA score, with correlation coefficients of -0.67, -0.73, and -0.77, respectively.
In elderly patients with acute insular infarction, infarction in the basal ganglia, thalamus, and mixed lesions were more likely to lead to cognitive dysfunction than in other areas, and patients with large infarct volumes were more likely to develop cognitive dysfunction. The infarct volume in the basal ganglia, thalamus, and mixed lesions was significantly negatively correlated with the MoCA score.
Core Tip: With the increasingly obvious aging of the population, the incidence of cerebral infarction is increasing year by year, which seriously leads to patient death. Most survivors suffer from sequelae such as cognitive dysfunction, aphasia and paralysis. This study aims to investigate the different clinical manifestations of patients with acute island infarction from the perspective of infarct location and volume, and mainly explore the influence of infarct location and volume on cognitive dysfunction in elderly patients with acute island infarction, hoping to evaluate cognitive function score, infarct location and volume. This can provide a basis for the clinical diagnosis and treatment of acute island infarction.