Wang CM, Xue H, Xin B, Zhang K, Wang S, Wang JC, An CX, Li N. Cognitive impairment in patients with bipolar disorder alone versus those with bipolar disorder comorbid with borderline personality disorder. World J Psychiatry 2024; 14(8): 1174-1181 [PMID: 39165560 DOI: 10.5498/wjp.v14.i8.1174]
Corresponding Author of This Article
Na Li, MD, PhD, Doctor, Department of Psychiatry, The First Hospital of Hebei Medical University, No. 89 Donggang Road, Yuhua District, Shijiazhuang 050031, Hebei Province, China. linaxdrs@163.com
Research Domain of This Article
Psychiatry
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Aug 19, 2024; 14(8): 1174-1181 Published online Aug 19, 2024. doi: 10.5498/wjp.v14.i8.1174
Cognitive impairment in patients with bipolar disorder alone versus those with bipolar disorder comorbid with borderline personality disorder
Chao-Min Wang, Hua Xue, Bo Xin, Kun Zhang, Shuo Wang, Jin-Cheng Wang, Cui-Xia An, Na Li
Chao-Min Wang, Hua Xue, Bo Xin, Kun Zhang, Shuo Wang, Jin-Cheng Wang, Cui-Xia An, Na Li, Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei Province, China
Co-first authors: Chao-Min Wang and Hua Xue.
Author contributions: Wang CM, Xue H, Xin B, and Li N designed the research; Zhang K, Wang S, and Wang JC analyzed the data; Wang CM, An XC, and Li N wrote the manuscript.
Supported byHebei Province Medical Science Research Project, No. 20221407.
Institutional review board statement: This study was approved by the institutional review board of The First Hospital of Hebei Medical University.
Informed consent statement: Informed consent was obtained form each participant.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data are available from the corresponding author.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Na Li, MD, PhD, Doctor, Department of Psychiatry, The First Hospital of Hebei Medical University, No. 89 Donggang Road, Yuhua District, Shijiazhuang 050031, Hebei Province, China. linaxdrs@163.com
Received: April 24, 2024 Revised: May 28, 2024 Accepted: July 10, 2024 Published online: August 19, 2024 Processing time: 109 Days and 21.9 Hours
Abstract
BACKGROUND
Bipolar disorder (BD) is a severe mental illness. BD often coexists with borderline personality disorders, making the condition more complex.
AIM
To explore the differences in cognitive impairment between patients with BD and those with BD comorbid with borderline personality disorder.
METHODS
Eighty patients with BD and comorbid borderline personality disorder and 80 patients with BD alone were included in groups A and B, respectively, and 80 healthy volunteers were included as controls. Cognitive function in each group was evaluated using the Chinese version of the repeatable battery for the assessment of neuropsychological status (RBANS), the Stroop color-word test, and the Wechsler intelligence scale-revised (WAIS-RC).
RESULTS
The indices of the RBANS, Stroop color-word test, and WAIS-RC in groups A and B were significantly lower than those of the control group (P < 0.05). Group A had significantly longer Stroop color-word test times for single-character, single-color, double-character, and double-color, lower scores of immediate memory, visual breadth, verbal function dimensions and total score of the RBANS, as well as lower scores of verbal IQ, performance IQ, and overall IQ of the WAIS-RC compared with group B (P < 0.05). Compared to group B, group A exhibited significantly longer single-character time, single-color time, double-character time, and double-color time in the Stroop color-word test (P < 0.05).
CONCLUSION
The cognitive function of patients with BD complicated with borderline personality disorder is lower than that of patients with BD.
Core Tip: This study explored the differences in cognitive impairment between patients with bipolar disorder and those with bipolar disorder comorbid with borderline personality disorder. The cognitive function of both patients with bipolar affective disorder alone and those with bipolar affective disorder complicated with borderline personality disorder showed extensive damage, and the cognitive impairment was considerably aggravated in patients with bipolar affective disorder comorbid with borderline personality disorder compared with those with bipolar affective disorder alone.
