Liu Q, Huang Z, Xu P. Effects of hormone replacement therapy on mood and sleep quality in menopausal women. World J Psychiatry 2024; 14(7): 1087-1094 [PMID: 39050194 DOI: 10.5498/wjp.v14.i7.1087]
Corresponding Author of This Article
Zhen Huang, MMed, Attending Doctor, Department of Gynecology, Ganzhou Women’s and Children’s Hospital, No. 25 Nankang Road, Ganzhou 341000, Jiangxi Province, China. hz1464044888@126.com
Research Domain of This Article
Psychiatry
Article-Type of This Article
Randomized Clinical Trial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Jul 19, 2024; 14(7): 1087-1094 Published online Jul 19, 2024. doi: 10.5498/wjp.v14.i7.1087
Effects of hormone replacement therapy on mood and sleep quality in menopausal women
Qing Liu, Zhen Huang, Ping Xu
Qing Liu, Zhen Huang, Ping Xu, Department of Gynecology, Ganzhou Women’s and Children’s Hospital, Ganzhou 341000, Jiangxi Province, China
Author contributions: Liu Q and Huang Z designed the research study; Liu Q, Huang Z, and Xu P performed the primary literature review and data extraction, analyzed the data, and wrote the manuscript; Liu Q and Huang Z revised the manuscript for important intellectual content; All authors have read and approved the final version.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Committee of Ganzhou Women’s and Children’s Hospital.
Clinical trial registration statement: This study is registered at the Clinical Trial Center (www.researchregistry.com). The registration identification number is researchregistry10341.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Data sharing statement: No other data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhen Huang, MMed, Attending Doctor, Department of Gynecology, Ganzhou Women’s and Children’s Hospital, No. 25 Nankang Road, Ganzhou 341000, Jiangxi Province, China. hz1464044888@126.com
Received: April 30, 2024 Revised: May 29, 2024 Accepted: June 18, 2024 Published online: July 19, 2024 Processing time: 72 Days and 20.7 Hours
Abstract
BACKGROUND
Hormone replacement therapy is an effective treatment strategy for the management of symptoms in naturally menopausal women. However, some patients report experiencing adverse effects.
AIM
To analyze the effects of hormone replacement therapy in menopausal female patients.
METHODS
A total of 152 menopausal female patients admitted to the Gynecology Department of the Ganzhou Maternal and Child Health Hospital between January 2021 and December 2023 were divided into the observation group (n = 76, conventional treatment + hormone replacement therapy) and the control group (n = 76, conventional treatment only) via random casting. The improvement observed in the following items were compared between the groups: Kupperman menopausal index (KMI), emotional state [The Positive and Negative Affect Scale (PANAS)], sleep quality [Self-Rating Scale of Sleep (SRSS)], treatment effectiveness, and treatment safety.
RESULTS
The modified KMI and SRSS scores of the observation group were lower than those of the control group after three rounds of treatment. The improvement in the PANAS score observed in the observation group was greater than that observed in the control group (P < 0.05). The total treatment effectivity rate in the observation group was higher than that in the control group (86.84% vs 96.05%, χ2 = 4.121, P = 0.042). The incidence rate of adverse reactions in the two groups was comparable (6.58% vs 9.21%, χ2 = 0.361, P = 0.547).
CONCLUSION
Hormone replacement therapy effectively improved the clinical symptoms, actively channeled negative emotions, and improved the quality of sleep in menopausal patients, indicating its effectiveness and safety.
Core Tip: Menopausal females can benefit from hormone replacement therapy; however, this treatment may increase the risk of venous thrombosis, cardiovascular disease, and breast cancer.
