Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jul 19, 2024; 14(7): 1034-1042
Published online Jul 19, 2024. doi: 10.5498/wjp.v14.i7.1034
Impact of early refined nursing program on prognosis of middle-aged and elderly patients with cognitive dysfunction combined with cerebral infarction
Hui-Lian Xiong, Zhi-Xin Li, Xin Lu, Yan-Hua Lu, Ping Zhong
Hui-Lian Xiong, Ganzhou City Central Blood Station, Ganzhou 341000, Jiangxi Province, China
Zhi-Xin Li, Xin Lu, Yan-Hua Lu, Ping Zhong, Department of Rehabilitation Medicine, Ganzhou People's Hospital, Ganzhou 341000, Jiangxi Province, China
Author contributions: Xiong HL designed and conducted this study; Lu X, Lu YH, and Zhong P completed the nursing process and data integration and analysis; Xiong HL completed the writing of the manuscript; Zhong P completed the review of the manuscript.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Ganzhou People's Hospital (No. 200230107).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at 18907978427@163.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ping Zhong, Department Rehabilitation Medicine, Ganzhou People's Hospital, No. 17 Hongqi Avenue, Ganzhou 341000, Jiangxi Province, China.18907978427@163.com
Received: April 7, 2024
Revised: May 10, 2024
Accepted: May 27, 2024
Published online: July 19, 2024
Processing time: 95 Days and 18.1 Hours
Abstract
BACKGROUND

Cerebral infarction is a local or extensive necrosis of brain tissue. Subsequently, the corresponding neurological deficits appear. The incidence of cerebrovascular diseases in China is increasing gradually. After the onset of cerebrovascular disease, the most common sequelae include movement disorders, language disorders, and cognitive dysfunction.

AIM

To investigate the effect of early refined nursing program on the prognosis of middle-aged and elderly patients with cerebral infarction combined with cognitive dysfunction.

METHODS

A retrospective study was conducted to divide 60 patients with cerebral infarction and cognitive impairment into an experimental group (n = 32) and a control group (n = 28). The experimental group received early intensive care every day, and the control group received daily routine care. The scores of the Mini-Mental State Examination (MMSE) and the Trail Making Test (TMT), as well as the latency and amplitude of the event-related potential P300, were used as main indicators to evaluate changes in cognitive function, and changes in BDNF, TGF-β, and GDNF expression were used as secondary indicators.

RESULTS

Both groups experienced notable enhancements in MMSE scores, with the experimental group demonstrating higher scores than the control group (experimental: 28.75 ± 2.31; control: 25.84 ± 2.87). Moreover, reductions in TMT-A and TMT-B scores were observed in both groups (experimental: TMT-A 52.36 ± 6.18, TMT-B 98.47 ± 10.23; control: TMT-A 61.48 ± 7.92, TMT-B 112.63 ± 12.55), with the experimental group displaying lower scores. P300 Latency decreased (experimental: 270.63 ms ± 14.28 ms; control: 285.72 ms ± 16.45 ms), while amplitude increased (experimental: 7.82 μV ± 1.05 μV; control: 6.35 μV ± 0.98 μV) significantly in both groups, with superior outcomes in the experimental cohort. Additionally, the levels of the growth factors BDNF, TGF-β1, and GDNF surged (experimental: BDNF 48.37 ng/mL ± 5.62 ng/mL, TGF-β1 52.14 pg/mL ± 4.28 pg/mL, GDNF 34.76 ng/mL ± 3.89 ng/mL; control: BDNF 42.58 ng/mL ± 4.73 ng/mL, TGF-β1 46.23 pg/mL ± 3.94 pg/mL, GDNF 30.25 ng/mL ± 2.98 ng/mL) in both groups, with higher levels in the experimental group.

CONCLUSION

For middle-aged and elderly patients with cerebral infarction and cognitive dysfunction, early refined nursing can significantly improve their cognitive function and prognosis.

Keywords: Early refined nursing program, Cerebral infraction, Cognitive impairment, Psychiatry, Trajectory test

Core Tip: The incidence of cerebrovascular diseases in China is increasing gradually. After the onset of cerebrovascular disease, the most common sequelae include movement disorders, language disorders, and cognitive dysfunction. Cognitive impairment in patients with cerebral infarction may or may not be accompanied by focal dysfunction, such as apraxia, agnosia, aphasia, memory impairment, and executive dysfunction. For middle-aged and elderly patients with cerebral infarction and cognitive dysfunction, early refined nursing can significantly improve their cognitive function and prognosis.