Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jul 19, 2024; 14(7): 1017-1026
Published online Jul 19, 2024. doi: 10.5498/wjp.v14.i7.1017
Identifying relevant factors influencing cancer-related fatigue in patients with diffuse large B-cell lymphoma during chemotherapy
Xiu-Qiao Hao, Xiang-Dan Yang, Yue Qi
Xiu-Qiao Hao, Xiang-Dan Yang, Yue Qi, Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Author contributions: Hao XQ and Qi Y initiated the project; Yang XD designed the experiment and conducted clinical data collection; Qi Y performed postoperative follow-up and recorded data; Hao XQ and Qi Y conducted a number of collation and statistical analysis and wrote the original manuscript; All authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of the Fourth Hospital of Hebei Medical University (No. 2020ky022) and abided by the ethical guidelines of the Declaration of Helsinki.
Informed consent statement: All patients provided signed informed consent.
Conflict-of-interest statement: The author(s) declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yue Qi, MM, Department of Hematology, The Fourth Hospital of Hebei Medical University, No. 169 Tianshan Street, East Development Zone, Shijiazhuang 050011, Hebei Province, China. qi15931696485@163.com
Received: March 21, 2024
Revised: May 9, 2024
Accepted: June 13, 2024
Published online: July 19, 2024
Processing time: 112 Days and 17.1 Hours
Abstract
BACKGROUND

Diffuse large B-cell lymphoma (DLBCL) is a rapidly growing malignant tumor, and chemotherapy is one of the treatments used to combat it. Although advancements of science and technology have resulted in more and more patients being able to receive effective treatment, they still face side effects such as fatigue and weakness. It is important to thoroughly investigate the factors that contribute to cancer-related fatigue (CRF) during chemotherapy.

AIM

To explore the factors related to CRF, anxiety, depression, and mindfulness levels in patients with DLBCL during chemotherapy.

METHODS

General information was collected from the electronic medical records of eligible patients. Sleep quality and mindfulness level scores in patients with DLBCL during chemotherapy were evaluated by the Pittsburgh Sleep Quality Index and Five Facet Mindfulness Questionnaire-Short Form. The Piper Fatigue Scale was used to evaluate the CRF status. The Self-Rating Anxiety Scale and Self-Rating Depression Scale were used to evaluate anxiety and depression status. Univariate analysis and multivariate regression analysis were used to investigate the factors related to CRF.

RESULTS

The overall average CRF level in 62 patients with DLBCL during chemotherapy was 5.74 ± 2.51. In 25 patients, the highest rate of mild fatigue was in the cognitive dimension (40.32%), and in 35 patients the highest moderate fatigue rate in the behavioral dimension (56.45%). In the emotional dimension, severe fatigue had the highest rate of occurrence, 34 cases or 29.03%. The CRF score was positively correlated with cancer experience (all P < 0.01) and negatively correlated with cancer treatment efficacy (all P < 0.01). Tumor staging, chemotherapy cycle, self-efficacy level, and anxiety and depression level were related to CRF in patients with DLBCL during chemotherapy.

CONCLUSION

There was a significant correlation between CRF and perceptual control level in patients. Tumor staging, chemotherapy cycle, self-efficacy level, and anxiety and depression level influenced CRF in patients with DLBCL during chemotherapy.

Keywords: Diffuse large B-cell lymphoma, Chemotherapy, Cancer-related fatigue, Anxiety, Depression, Mindfulness

Core Tip: The study aimed to explore the factors related to cancer-related fatigue (CRF), anxiety, depression, and mindfulness level in patients with diffuse large B-cell lymphoma (DLBCL) during chemotherapy. Univariate analysis and multivariate regression analysis were used to investigate the related factors of CRF. The overall average level of CRF in 62 patients with DLBCL during chemotherapy was 5.74 ± 2.51. There was a significant correlation between CRF and perceptual control level in patients with DLBCL during chemotherapy. Tumor staging, chemotherapy cycle, self-efficacy level, and anxiety and depression level influenced CRF in patients with DLBCL during chemotherapy.