Wang HJ, Chen W, Yan XL, Huang QY, Xu WD. Effect of comprehensive intervention model based on drug-psychology-society-skills on medication compliance and cognitive ability of chronic schizophrenia patients. World J Psychiatry 2024; 14(12): 1947-1955 [DOI: 10.5498/wjp.v14.i12.1947]
Corresponding Author of This Article
Hai-Jun Wang, BSc, Chief Doctor, The Fourth Ward, The Third People’s Hospital of Yongkang, No. 18 Feifeng Road, Yongkang 321300, Zhejiang Province, China. 13819907042@163.com
Research Domain of This Article
Psychiatry
Article-Type of This Article
Randomized Controlled Trial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Dec 19, 2024; 14(12): 1947-1955 Published online Dec 19, 2024. doi: 10.5498/wjp.v14.i12.1947
Effect of comprehensive intervention model based on drug-psychology-society-skills on medication compliance and cognitive ability of chronic schizophrenia patients
Hai-Jun Wang, Wei-Dong Xu, The Fourth Ward, The Third People’s Hospital of Yongkang, Yongkang 321300, Zhejiang Province, China
Wei Chen, Department of Psychiatry, Zhejiang University School of Medicine, and the Collaborative Innovation Center for Brain Science, Zhejiang University Affiliated SIR Run Run Shaw Hospital, Hangzhou 311100, Zhejiang Province, China
Xiao-Lin Yan, Department of Laboratory Medicine, The Third People’s Hospital of Yongkang, Yongkang 321300, Zhejiang Province, China
Qian-Ying Huang, The Third Ward, The Third People’s Hospital of Yongkang, Yongkang 321300, Zhejiang Province, China
Author contributions: Wang HJ designed research, and performed research; Yan XL and Huang QY contributed new reagents or analytic tools; Xu WD analyzed data; Wang HJ and Chen W wrote the paper.
Institutional review board statement: The study was reviewed and approved by the institutional review board of Third People’s Hospital of Yongkang, No. YKSY-2023-LC-2023-9-19A1.
Clinical trial registration statement: This study was not registered with ClinicalTrials.gov. This study is not applicable to clinical trial.
Informed consent statement: All subjects agreed to the study protocol and signed the informed consent form.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: Not applicable.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Jun Wang, BSc, Chief Doctor, The Fourth Ward, The Third People’s Hospital of Yongkang, No. 18 Feifeng Road, Yongkang 321300, Zhejiang Province, China. 13819907042@163.com
Received: September 12, 2024 Revised: October 20, 2024 Accepted: November 5, 2024 Published online: December 19, 2024 Processing time: 76 Days and 2.2 Hours
Abstract
BACKGROUND
The intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia was unknown.
AIM
To explore the intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia.
METHODS
Overall, 98 out-patients and in-patients with chronic schizophrenia treated in our hospital from February 2022 to January 2023 were included and randomly divided into the study (50 patients) and control groups (48 patients). For 3 months, the control group was treated with conventional drugs, and the research group with a comprehensive intervention model of drug-psychology-society-skills. Data were obtained for the mini mental assessment scale (MMSE), Montreal cognitive assessment scale (MoCA), positive and negative symptom scale, insight and treatment attitude scale, cognitive ability scale and social skills [personal and social function scale (PSP)]. The adverse reactions were observed.
RESULTS
After the intervention, the MMSE and MoCA scores improved in both groups. MoCA scores in the study group (26.58 ± 3.21) were significantly (P < 0.05) higher than those in the control group (24.68 ± 3.02), MMSE scores were not significantly higher. Post-intervention, positive and negative symptom scores improved in both groups, and the positive and negative symptom scores in the study group [(12.01 ± 2.58) and (32.51 ± 2.11)] were significantly (P < 0.05) different than those in the control group [(14.54 ± 2.33) and (33.74 ± 2.55)]. Post-intervention, insight and treatment attitudes questionnaire scores of both groups were improved and compared with the control group (7.97 ± 3.02), the study group (13.56 ± 6.35) had significantly (P < 0.05) higher scores. Post-intervention, the MATRICS consensus cognitive battery score of both groups was improved and compared with the control group (38.44 ± 6.23), the score of the study group was significantly (P < 0.05) increased (43.51 ± 6.01). Post-intervention, the PSP score of the study group (78.38 ± 6.63) was significantly (P < 0.05) higher than that of the control group (74.52 ± 7.01). During the intervention period, the incidence of adverse reactions in the study group was 6.25%, not significantly different from that in the control group (8.33%). During the intervention, both groups experienced adverse reactions, with no significant difference between groups (P > 0.05).
CONCLUSION
The comprehensive intervention model based on drug-psychology-society-skills has obvious intervention effects on patients with chronic schizophrenia, which improves their cognitive ability and reduces their positive and negative symptoms. Simultaneously, it improves the self-knowledge of patients, improves their attitude toward treatment, effectively promotes the recovery of patients' social functions, and is safe. Therefore, it is worthy of being vigorously promoted and widely used in clinics.
Core Tip: The comprehensive intervention model based on drug-psychology-society-skills has obvious intervention effect on patients with chronic schizophrenia, which not only improves the cognitive ability of patients, but also reduces the positive and negative symptoms of patients.
