Liu DW, Zhou XA, Wu XY, Wang YX, Fan JT, Li ZL. Mindfulness-based stress reduction training and supplemented Jinshui Liujun decoction promote recovery in patients with non-small cell lung cancer. World J Psychiatry 2024; 14(12): 1876-1885 [DOI: 10.5498/wjp.v14.i12.1876]
Corresponding Author of This Article
Zhan-Lin Li, MD, Professor, Department of Traditional Chinese Medicine, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Qiaoxi District, Zhangjiakou 075000, Hebei Province, China. zjklzl@sohu.com
Research Domain of This Article
Psychiatry
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dai-Wei Liu, Xiao-Yuan Wu, Yong-Xia Wang, Jie-Ting Fan, Zhan-Lin Li, Department of Traditional Chinese Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China
Xue-An Zhou, Hebei North University, Zhangjiakou 075000, Hebei Province, China
Author contributions: Liu DW and Zhou XA wrote the paper; Wu XY, Wang YX, and Fan JT performed data extraction; Li ZL supervised the paper; and all authors read and approved the final version.
Supported byZhangjiakou Science and Technology Plan Project, No. 2021127H; and Scientific Research Program Project of Hebei Provincial Administration of Traditional Chinese Medicine, No. 2022146.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the First Affiliated Hospital of Hebei North University, Approval No. K2020227.
Informed consent statement: All study participants or their legal guardians provided written informed consent for personal and medical data collection before study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data used in this study can be obtained from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhan-Lin Li, MD, Professor, Department of Traditional Chinese Medicine, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Qiaoxi District, Zhangjiakou 075000, Hebei Province, China. zjklzl@sohu.com
Received: August 20, 2024 Revised: September 17, 2024 Accepted: September 27, 2024 Published online: December 19, 2024 Processing time: 99 Days and 2.3 Hours
Abstract
BACKGROUND
Conventional chemotherapy (CC) administered to patients with non-small cell lung cancer (NSCLC) often causes adverse effects, such as cardiopulmonary dysfunction and immune system imbalance. Patients may experience anxiety and depression during the perioperative period due to various factors, such as treatment costs and cancer recurrence risks, thereby compromising the overall quality of life. Consequently, we hypothesized that integrating mindfulness-based stress reduction training (MSRT) with Jinshui Liujun decoction may mitigate negative emotions and promote recovery in patients with NSCLC.
AIM
To explore the effects of MSRT and Jinshui Liujun decoction on the immune function and emotional state of NSCLC patients.
METHODS
A retrospective clinical study was conducted involving 92 patients with stage IIIb-IV NSCLC; 35 patients in the control group (CG) received CC therapy (combination of pemetrexed and carboplatin), and 57 patients in the treatment group (TG) received MSRT-assisted flavored Jinshui Liujun decoction (FJLD) in addition to CC. We evaluated the survival time, Karnofsky performance status, treatment efficacy, traditional Chinese medicine syndrome score, immune function, negative emotional level, and adverse reactions of the CG and TG.
RESULTS
Median progression-free survival, Karnofsky performance status, and clinical efficacy of the TG were superior to those of the CG (P < 0.05). Symptoms of cough, weakness, bloody sputum, shortness of breath, and chest pain significantly decreased in the TG compared to that in the CG (P < 0.05). In the TG, MSRT + FJLD treatment increased the numbers of CD3+ and CD4+ immune cells, effectively reduced the number of CD8+ cells, and enhanced the CD4+/CD8+ ratio, thereby restoring the immune function of patients. In the TG, the self-rating anxiety scale and self-rating depression scale scores decreased significantly. There was no statistically significant difference in the incidence of adverse reactions between the CG and TG (P > 0.05).
CONCLUSION
MSRT + FJLD proved to be an effective treatment for patients with NSCLC.
Core Tip: The combined effects of mindfulness-based stress reduction training with flavored Jinshui Liujun decoction and conventional chemotherapy on survival time, Karnofsky performance status, traditional Chinese medicine syndrome score, immune function, negative emotion levels, and incidence of adverse reactions in patients with non-small cell lung cancer were evaluated. We found that combining mindfulness-based stress reduction training + flavored Jinshui Liujun decoction with conventional chemotherapy for patients with non-small cell lung cancer extended survival time, improved Karnofsky performance status scores, increased CD3+ and CD4+ immune cells, reduced CD8+ cells, and improved the CD4+/CD8+ ratio, thereby restoring immune function.
