Meta-Analysis
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Oct 19, 2024; 14(10): 1573-1582
Published online Oct 19, 2024. doi: 10.5498/wjp.v14.i10.1573
Association between 5-HTR1A gene C-1019G polymorphism and antidepressant response in patients with major depressive disorder: A meta-analysis
Huai-Neng Wu, Shuang-Yue Zhu, Li-Na Zhang, Bian-Hong Shen, Lian-Lian Xu
Huai-Neng Wu, Shuang-Yue Zhu, Li-Na Zhang, Bian-Hong Shen, Lian-Lian Xu, Department of Psychiatry, Affiliated Mental Health Center and Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310013, Zhejiang Province, China
Co-first authors: Huai-Neng Wu and Shuang-Yue Zhu.
Author contributions: Wu HN and Zhu SY contributed to the conception of the study; Zhang LN contributed significantly to literature search, data extraction, quality assessment, data analyses and manuscript preparation; Shen BH contributed improving the article for language and style and protocol preparation; Wu HN and Zhu SY helped perform the analysis with constructive discussions; Xu LL revised the manuscript and approved the final version; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: The authors declare that they have no competing interests.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lian-Lian Xu, MM, Doctor, Department of Psychiatry, Affiliated Mental Health Center and Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, No. 305 Tianmu Mountain Road, Hangzhou 310013, Zhejiang Province, China. xulianlian2007@126.com
Received: April 27, 2024
Revised: September 11, 2024
Accepted: September 23, 2024
Published online: October 19, 2024
Processing time: 173 Days and 1.8 Hours
Abstract
BACKGROUND

Major depressive disorder (MDD) is a substantial global health concern, and its treatment is complicated by the variability in individual response to antidepressants.

AIM

To consolidate research and clarify the impact of genetic variation on MDD treatment outcomes.

METHODS

Adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic search across PubMed, EMBASE, Web of Science, and the Cochrane Library was conducted without date restrictions, utilizing key terms related to MDD, serotonin 1A receptor polymorphism (5-HTR1A), C-1019G polymorphism, and antidepressant response. Studies meeting inclusion criteria were thoroughly screened, and quality assessed using the Newcastle-Ottawa Scale. Statistical analyses, including χ2 and I² values, were used to evaluate heterogeneity and fixed-effect or random-effect models were applied accordingly.

RESULTS

The initial search yielded 1216 articles, with 11 studies meeting criteria for inclusion. Analysis of various genetic models showed no significant association between the 5-HTR1A C-1019G polymorphism and antidepressant efficacy. The heterogeneity was low to moderate, and no publication bias was detected through funnel plot symmetry and Egger's and Begg's tests.

CONCLUSION

This meta-analysis does not support a significant association between the 5-HTR1A C-1019G polymorphism and the efficacy of antidepressant treatment in MDD. The findings call for further research with larger cohorts to substantiate these results and enhance the understanding of antidepressant pharmacogenetics.

Keywords: Major depressive disorder; Antidepressant efficacy; 5-HTR1A gene; C-1019G polymorphism; Meta-analysis

Core Tip: This study investigates whether the serotonin 1A receptor polymorphism C-1019G polymorphism influences antidepressant efficacy in major depressive disorder (MDD). Despite extensive research, our meta-analysis involving 11 selected studies shows no significant correlation between this genetic variation and treatment outcomes. These findings underscore the complexity of antidepressant pharmacogenetics and highlight the need for further large-scale studies to clarify the role of genetic factors in MDD treatment response. This work contributes to the ongoing discussion and development of personalized medicine strategies in psychiatry.