Observational Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Sep 19, 2023; 13(9): 675-684
Published online Sep 19, 2023. doi: 10.5498/wjp.v13.i9.675
Factors influencing spiritual wellbeing among pancreatic ductal adenocarcinoma patients receiving chemotherapy
Ling-Ling Wei, Shu-Ting Zhang, Yu Liao, Yue Zhang, Yan Yu, Na Mi
Ling-Ling Wei, Shu-Ting Zhang, Yu Liao, Yue Zhang, Yan Yu, Na Mi, Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Army Medical University, Chongqing 400037, China
Author contributions: Wei LL, Zhang ST contributed to the conception and design of the study; Wei LL and Zhang ST contributed equally to this work as joint first authors; Mi N contributed to the administrative support; Liao Y contributed to the provision of study materials or patients; Zhang ST, Liao Y, Zhang Y, Yu Y collected and analyzed the data; and all authors have read and approved the final manuscript.
Supported by Humanities and Social Science Foundation Project of Army Military Medical University, No. 2021XRW09.
Institutional review board statement: The study procedures were approved by the Ethics Committee of the Second Affiliated Hospital of Army Medical University (2021- Research No.161-01).
Informed consent statement: Written informed consent was obtained from all participants.
Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Data sharing statement: The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
STROBE statement: The authors have read the STROBE Statement- checklist of items, and the manuscript was prepared and revised according to the STROBE Statement- checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Na Mi, BSc, Associate Chief Nurse, Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Army Medical University, Xinqiao Street, Chongqing 400037, China. mina_email@163.com
Received: May 24, 2023
Peer-review started: May 24, 2023
First decision: June 12, 2023
Revised: June 25, 2023
Accepted: August 2, 2023
Article in press: August 2, 2023
Published online: September 19, 2023
Processing time: 114 Days and 9.1 Hours
Abstract
BACKGROUND

Spiritual wellbeing emphasizes optimistic and positive attitudes while self-regulating negative emotions when coping with stress. However, there have only been a few small studies of spiritual wellbeing of pancreatic ductal adenocarcinoma (PDAC) patients undergoing chemotherapy. The core factors influencing spiritual wellbeing in this clinical population are still unclear.

AIM

To identify factors influencing spiritual wellbeing among patients with PDAC receiving chemotherapy.

METHODS

A total of 143 PDAC patients receiving chemotherapy were enrolled from January to December 2022. Patients completed general information questionnaires including: Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being 12 Item Scale (FACIT-Sp-12), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and Zung’s Self-rating Anxiety Scale (SAS). Independent sample t-test, one-way analysis of variance, Pearson’s correlation analysis, and multiple linear regression analysis were adopted for statistical analyses. P < 0.05 (two-tailed) was considered statistically significant for all tests.

RESULTS

Total spiritual wellbeing (FACIT-Sp-12) score was 32.16 ± 10.06 points, while dimension sub-scores were 10.85 ± 3.76 for faith, 10.55 ± 3.42 for meaning, and 10.76 ± 4.00 for peace. Total spiritual wellbeing score was negatively correlated with SAS score for anxiety and with the symptom domain of EORTC QLC-C30. Conversely, spiritual wellbeing score was positively correlated with global health status and EORTC QLQ-C30 role functioning domain score. Multivariate regression analysis identified educational level, health insurance category, symptom domain, functional role domain, and global health status as significant independent factors influencing spiritual wellbeing among PDAC patients undergoing chemotherapy (R2 = 0.502, P < 0.05).

CONCLUSION

Individualized spiritual support is needed for PDAC patients. Health, daily functioning, emotional, cognitive, and social function status should be taken into account to promote implementation of spirituality in nursing practice.

Keywords: Pancreatic ductal adenocarcinoma; Chemotherapy; Spiritual wellbeing; Quality of life; Anxiety

Core Tip: Identifying the core factors influencing spiritual wellbeing of pancreatic ductal adenocarcinoma (PDAC) patients undergoing chemotherapy and formulating individualized spiritual care regimens can improve quality of life. However, there have only been a few small studies on spiritual wellbeing of PDAC patients undergoing chemotherapy. The core factors influencing spiritual wellbeing in this clinical population are still unclear. In this study, we analyzed factors influencing the spiritual wellbeing of PDAC patients undergoing chemotherapy, the newest study of PDAC patients undergoing chemotherapy in Mainland China.