Published online Apr 19, 2020. doi: 10.5498/wjp.v10.i4.59
Peer-review started: November 4, 2019
First decision: December 26, 2019
Revised: February 26, 2020
Accepted: March 12, 2020
Article in press: March 12, 2020
Published online: April 19, 2020
Processing time: 164 Days and 19.5 Hours
The prevalence of depression in patients with chronic obstructive pulmonary disease (COPD) ranges from 10% to 42%, but the diagnosis of depression in patients with COPD is often unrecognized and untreated. Unrecognized depression has major implications for compliance with medical treatment, prolonged lengths of stay, increased frequency of hospital admissions, and increased consultations with primary care physicians. Many studies have attempted to identify risk factors for progression, prognosis and response to therapy in patients with depression. However, few studies have examined the risk factors for depression in patients with COPD, and some results remain controversial.
To identify the potential risk factors to define patients with COPD who are at “high risk” of depression.
The clinical data of 293 patients with COPD were reviewed from January 2017 to December 2018. The correlations between demographics, clinical characteristics and depression were analyzed. The risk factors for depression in patients with COPD were identified by multivariate logistic regression analysis. The cutoff value, sensitivity and specificity of the independent correlation factors were calculated with a receiver operating characteristic curve.
Of the 293 patients included, 65 (22.18%) individuals were identified to have depression. Significant differences were detected between patients with and without depression in terms of body mass index (BMI), forced expiratory volume in 1 s (FEV1), and COPD assessment test (CAT) score (all P < 0.05). Low BMI, low FEV1, and high CAT were independent risk factors for depression in patients with COPD and the cutoff values of BMI, FEV1, and CAT scores were 21.373 kg/m2, 0.855 L and 12.5, respectively.
Low BMI, low FEV1, and high CAT score were identified as independent risk factors for depression in patients with COPD.
Core tip: The prevalence of depression in patients with chronic obstructive pulmonary disease (COPD) ranges from 10% to 42%. However, the risk factors for depression in patients with COPD have been examined in few studies, and some results remain controversial. The purpose of the current study is to investigate the correlation between clinical parameters and the symptoms of depression, and to identify independent risk factors to define patients with COPD who are at “high risk” of depression. Low body mass index, low forced expiratory volume in 1 s and high chronic obstructive pulmonary disease assessment test score were identified as independent risk factors for depression in patients with COPD.