1
|
Izquierdo-Condoy JS, Paz C, Nati-Castillo HA, Gollini-Mihalopoulos R, Aveiro-Róbalo TR, Valeriano Paucar JR, Laura Mamami SE, Caicedo JF, Loaiza-Guevara V, Mejía DC, Salazar-Santoliva C, Villavicencio-Gomezjurado M, Hall C, Ortiz-Prado E. Impact of Mobile Phone Usage on Sleep Quality Among Medical Students Across Latin America: Multicenter Cross-Sectional Study. J Med Internet Res 2025; 27:e60630. [PMID: 39928921 DOI: 10.2196/60630] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/16/2024] [Revised: 12/13/2024] [Accepted: 12/14/2024] [Indexed: 02/12/2025] Open
Abstract
BACKGROUND The ubiquitous use of mobile phones among medical students has been linked to potential health consequences, including poor sleep quality. OBJECTIVE This study investigates the prevalence of mobile phone addiction and its association with sleep quality among medical students across 6 Latin American countries. METHODS A descriptive, cross-sectional, multicenter study was conducted between December 2023 and March 2024 using a self-administered online survey. The survey incorporated the Mobile Phone Addiction Scale and the Pittsburgh Sleep Quality Index to evaluate mobile phone addiction and sleep quality among 1677 medical students. A multiple regression model was applied to analyze the relationship between mobile phone addiction and poor sleep quality, adjusting for sex, age, and educational level to ensure robust results. RESULTS Mobile phone addiction was identified in 32.5% (545/1677) of participants, with significant differences across countries. The overall mean Pittsburgh Sleep Quality Index score was 7.26, indicating poor sleep quality. Multiple regression analysis revealed a strong association between mobile phone addiction and poor sleep, controlled for demographic variables (β=1.4, 95% CI 1.05-1.74). CONCLUSIONS This study underscores a significant prevalence of mobile phone addiction among medical students and its detrimental association with sleep quality in Latin America. The findings advocate for the need to address mobile phone usage to mitigate its negative implications on student health and academic performance. Strategies to enhance digital literacy and promote healthier usage habits could benefit medical education and student well-being.
Collapse
Affiliation(s)
| | - Clara Paz
- Grupo de Investigación Bienestar, Salud y Sociedad, Escuela de Psicología y Educación, Universidad de Las Américas, Quito, Ecuador
| | - H A Nati-Castillo
- Interinstitutional Internal Medicine Group (GIMI 1), Department of Internal Medicine, Universidad Libre, Cali, Colombia
| | | | | | | | | | - Juan Felipe Caicedo
- Facultad de Ciencias de la Salud, Universidad del Quindío, Armenia, Colombia
| | | | - Diana Camila Mejía
- Facultad de Ciencias de la Salud, Universidad del Quindío, Armenia, Colombia
| | | | | | - Cougar Hall
- Public Health Department, Bringham Young University, Provo, UT, United States
| | | |
Collapse
|
2
|
Sousa K, Picada JN, da Silva GR, Solka LDC, de Oliveira IM, Henriques JAP, Campo LF, Corrêa DS. Innovative Photoprotection Strategy: Development of 2-(Benzoxazol-2-Yl)[(2-Hydroxynaphthyl)Diazenyl] Phenol Derivatives for Comprehensive Absorption of UVB, UVA, and Blue Light. Chem Biol Drug Des 2024; 104:e70020. [PMID: 39567468 DOI: 10.1111/cbdd.70020] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/29/2024] [Revised: 10/30/2024] [Accepted: 11/04/2024] [Indexed: 11/22/2024]
Abstract
Overexposure to blue light due to the excessive use of electronic devices has been implicated in premature skin aging and eye damage, among other injuries to health. This study aimed to synthesize two azo derivatives of the 2-(amino-2'-hydroxyphenyl) benzoxazole and explore their potential as UV and blue light filters, proposing a new spectral profile. The synthesis of the heterocyclic compounds involved condensation reactions and diazotation. The derivatives 2-(benzoxazol-2-yl)-5-[(2-hydroxynaphthyl)diazenyl]phenol and 2-(benzoxazol-2-yl)-4-[(2-hydroxynaphthyl)diazenyl]phenol were synthesized with a yield greater than 70%. Solubility was evaluated in seven different solvents. The maximum absorption wavelengths (λmax) were determined using UV-Vis scanning spectrophotometry in the range of 200-600 nm. Photostability was assessed using a solar simulator and the Sun protection factor (SPF) was determined using in vitro methodology. Cytotoxicity was evaluated using the MTT assay in V79 cells. These compounds were able to absorb UVA, UVB, and blue light, with λmax ranging from 300 to 500 nm and demonstrated photostability after 3 h of exposure to solar simulator with an SPF higher than 45. The compounds exhibited solubility in all lipophilic solvents tested. Regarding cytotoxicity, IC50 values were comparable to other filters. These findings indicate that both compounds hold promise as potential organic filters.
Collapse
Affiliation(s)
- Karen Sousa
- Laboratory of Genetic Toxicology, Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil
- Center for Research in Product and Development (CEPPED), Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil
| | | | - Gabriela Rodrigues da Silva
- Center for Research in Product and Development (CEPPED), Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil
| | - Larissa da Cunha Solka
- Center for Research in Product and Development (CEPPED), Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil
| | - Iuri Marques de Oliveira
- Department of Biophysics, Biotechnology Center, Federal University of Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil
| | - João Antonio Pêgas Henriques
- Department of Biophysics, Biotechnology Center, Federal University of Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil
- Postgraduate Program in Biotechnology and Medical Sciences, University of Vale Do Taquari (UNIVATES), Lajeado, RS, Brazil
| | - Leandra Franciscato Campo
- Laboratory of New Organic Materials and Forensic Chemistry, Federal University of Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil
| | - Dione Silva Corrêa
- Center for Research in Product and Development (CEPPED), Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil
| |
Collapse
|
3
|
Jiao H, Kalsbeek A, Yi CX. Microglia, circadian rhythm and lifestyle factors. Neuropharmacology 2024; 257:110029. [PMID: 38852838 DOI: 10.1016/j.neuropharm.2024.110029] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/19/2024] [Revised: 05/30/2024] [Accepted: 06/03/2024] [Indexed: 06/11/2024]
Abstract
Microglia, a vital homeostasis-keeper of the central nervous system, perform critical functions such as synaptic pruning, clearance of cellular debris, and participation in neuroinflammatory processes. Recent research has shown that microglia exhibit strong circadian rhythms that not only actively regulate their own immune activity, but also affect neuronal function. Disruptions of the circadian clock have been linked to a higher risk of developing a variety of diseases. In this article we will provide an overview of how lifestyle factors impact microglial function, with a focus on disruptions caused by irregular sleep-wake patterns, reduced physical activity, and eating at the wrong time-of-day. We will also discuss the potential connection between these lifestyle factors, disrupted circadian rhythms, and the role of microglia in keeping brain health. This article is part of the Special Issue on "Microglia".
Collapse
Affiliation(s)
- Han Jiao
- Department of Endocrinology and Metabolism, Amsterdam University Medical Center, location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology Endocrinology and Metabolism, Amsterdam, the Netherlands; Department of Clinical Chemistry, Laboratory of Endocrinology, Amsterdam University Medical Center, location AMC, Amsterdam, the Netherlands; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands
| | - Andries Kalsbeek
- Department of Endocrinology and Metabolism, Amsterdam University Medical Center, location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology Endocrinology and Metabolism, Amsterdam, the Netherlands; Department of Clinical Chemistry, Laboratory of Endocrinology, Amsterdam University Medical Center, location AMC, Amsterdam, the Netherlands; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands
| | - Chun-Xia Yi
- Department of Endocrinology and Metabolism, Amsterdam University Medical Center, location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology Endocrinology and Metabolism, Amsterdam, the Netherlands; Department of Clinical Chemistry, Laboratory of Endocrinology, Amsterdam University Medical Center, location AMC, Amsterdam, the Netherlands; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.
| |
Collapse
|
4
|
Congiu P, Carta MG, Perra A, Cantone E, Lorrai S, Pintus E, Tusconi M, Cossu G, Redolfi S, Sancassiani F. Prevalence and Risk by Age and Sex of Sleep Dysregulation and Depressive Episodes in Bipolar and Depressive Disorders in a Community Survey in Sardinia, Italy. J Clin Med 2024; 13:4870. [PMID: 39201012 PMCID: PMC11355541 DOI: 10.3390/jcm13164870] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/14/2024] [Revised: 08/09/2024] [Accepted: 08/16/2024] [Indexed: 09/02/2024] Open
Abstract
Background/Objectives: Sleep disturbances often accompany mood disorders and persistent insomnia after mood symptoms have resolved may be a marker of poor outcome. The association between sleep symptoms and mood disorders seems to change with age and sex. This study aims to assess the frequency of depressive episodes and sleep disorders in the general population through an agile screening questionnaire and to evaluate the association of depressive episodes and sleep symptoms by sex and age categories. Methods: 774 women and 728 men from Sardinia aged > 16 years old were enrolled. The Patient Health Questionnaire (PHQ-9) was administered through a computer-assisted telephonic interview. Results: The frequency of depressive episodes was double in women (10.6% vs. 4.4%; p < 0.0001), with the highest values in women > 75 yo (17.4%). The frequency of sleep dysregulation was double in women (18.7% vs. 9.6%; p < 0.0001), with the highest values in women > 75 yo (35.9%) and the lowest in the group of men > 75 yo. The group of young males showed the lowest frequency of depressive episodes (1.4%) and a frequency of sleep dysregulation (9.1%) similar to that of the other groups of age and sex. Sleep dysregulation without depressive episodes presented a higher distribution in the elderly, both in males (20.7%) and in females (18.5%). No significative differences were found across sex and age groups in the distribution of depressive episodes without sleep dysregulation. Conclusions: The use of an agile screener such as PHQ9 in the general population and/or in populations at risk can be a valuable tool in finding those individuals in whom sleep dysregulation may represent an early warning signal, one that may be thoroughly evaluated to identify and treat possible sleep disorders early.
Collapse
Affiliation(s)
- Patrizia Congiu
- Department of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari, 09124 Cagliari, Italy; (P.C.); (S.R.)
- Sleep Outpatient Service, Clinica Tommasini di Jerzu, 08044 Jerzu, Italy
| | - Mauro Giovanni Carta
- Department of Medical Sciences and Public Health, Section of Psychiatry, University of Cagliari, 09124 Cagliari, Italy; (M.G.C.); (A.P.); (E.C.); (S.L.); (E.P.); (G.C.); (F.S.)
| | - Alessandra Perra
- Department of Medical Sciences and Public Health, Section of Psychiatry, University of Cagliari, 09124 Cagliari, Italy; (M.G.C.); (A.P.); (E.C.); (S.L.); (E.P.); (G.C.); (F.S.)
| | - Elisa Cantone
- Department of Medical Sciences and Public Health, Section of Psychiatry, University of Cagliari, 09124 Cagliari, Italy; (M.G.C.); (A.P.); (E.C.); (S.L.); (E.P.); (G.C.); (F.S.)
| | - Stefano Lorrai
- Department of Medical Sciences and Public Health, Section of Psychiatry, University of Cagliari, 09124 Cagliari, Italy; (M.G.C.); (A.P.); (E.C.); (S.L.); (E.P.); (G.C.); (F.S.)
| | - Elisa Pintus
- Department of Medical Sciences and Public Health, Section of Psychiatry, University of Cagliari, 09124 Cagliari, Italy; (M.G.C.); (A.P.); (E.C.); (S.L.); (E.P.); (G.C.); (F.S.)
| | | | - Giulia Cossu
- Department of Medical Sciences and Public Health, Section of Psychiatry, University of Cagliari, 09124 Cagliari, Italy; (M.G.C.); (A.P.); (E.C.); (S.L.); (E.P.); (G.C.); (F.S.)
| | - Stefania Redolfi
- Department of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari, 09124 Cagliari, Italy; (P.C.); (S.R.)
| | - Federica Sancassiani
- Department of Medical Sciences and Public Health, Section of Psychiatry, University of Cagliari, 09124 Cagliari, Italy; (M.G.C.); (A.P.); (E.C.); (S.L.); (E.P.); (G.C.); (F.S.)
| |
Collapse
|
5
|
Chen Z, Liao X, Yang J, Tian Y, Peng K, Liu X, Li Y. Association of screen-based activities and risk of self-harm and suicidal behaviors among young people: A systematic review and meta-analysis of longitudinal studies. Psychiatry Res 2024; 338:115991. [PMID: 38833936 DOI: 10.1016/j.psychres.2024.115991] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/14/2023] [Revised: 05/20/2024] [Accepted: 05/28/2024] [Indexed: 06/06/2024]
Abstract
Emerging evidence suggests that screen-based activities are associated with self-harm and suicidal behaviors. This study aimed to examine these associations among young people through a meta-analysis. We systematically searched EBSCO pshyARTICLES, MEDLINE (via PubMed), EMBASE, and Web of Science from their inception to April 1, 2022, and updated on May 1, 2024. Longitudinal studies reporting the association between various screen-based activities and subsequent self-harm and suicidal behaviors in young people aged 10 to 24 were included. Nineteen longitudinal studies were included in the qualitative synthesis, and 13 studies comprising 43,489 young people were included in the meta-analysis, revealing that total screen use is significantly associated with the risks of self-harm and suicidal behaviors. Cyberbullying victimization was also related to these adverse outcomes. Subgroup analyses indicated that social media use and problematic screen use are significant risk factors for self-harm and suicidal behaviors. Study quality was appraised using the Newcastle-Ottawa Scale, and potential publication bias was deemed unlikely to affect the results significantly. These findings suggest that screen-based activities should be considered in the management and intervention strategies for self-harm and suicidal behaviors in young people.
Collapse
Affiliation(s)
- Zengyu Chen
- Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Xiangya School of Nursing, Central South University, Changsha, Hunan, China
| | - Xiaoli Liao
- Xiangya School of Nursing, Central South University, Changsha, Hunan, China
| | - Jiaxin Yang
- Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China; School of Computer Science and Engineering, Central South University, Changsha, Hunan, China
| | - Yusheng Tian
- Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
| | - Kexin Peng
- Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
| | - Xiaopei Liu
- Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
| | - Yamin Li
- Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
| |
Collapse
|
6
|
Cheng C, Chen S, Chen S. Impact of National Lockdown Measures on the Association Between Social Media Use and Sleep Disturbance During COVID-19: A Meta-Analysis of 21 Nations. CYBERPSYCHOLOGY, BEHAVIOR AND SOCIAL NETWORKING 2024; 27:527-538. [PMID: 38916117 DOI: 10.1089/cyber.2023.0571] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/26/2024]
Abstract
During the COVID-19 pandemic, the extensive lockdown measures implemented for disease mitigation triggered a surge in round-the-clock social media use, giving rise to widespread concerns regarding its impact on sleep health. This meta-analysis examined the association between social media use and sleep disturbance during the pandemic, along with potential moderators. The dataset included 43 independent samples comprising 68,247 residents of 21 countries across 7 world regions. The three-level mixed-effects meta-analysis revealed a weak, positive overall effect size (r = 0.1296, 95% confidence interval: 0.0764-0.1828, k = 90). The magnitude of the effect size varied by the type of social media use: compulsive use exhibited a moderately strong effect size, whereas information-focused use showed marginal significance. The effect size was more pronounced in countries imposing stricter (vs. less strict) lockdown measures. Lockdown status also moderated this association, with a marginally significant effect size observed during lockdowns but a significant effect size after lockdowns. For demographics, samples involving emerging adults demonstrated moderately strong effect sizes, whereas those involving the general population had modest effect sizes. Notably, the interaction between the type of social media use and lockdown status was significant. Specifically, the positive association with information-focused use was significant only during lockdowns, whereas that with general use was significant after, but not during, lockdowns. However, compulsive use showed a moderately strong effect size both during and after lockdowns. These findings underscored the importance of considering multiple factors-such as the type of social media use, context, and demographics-when studying social media use and sleep health.
Collapse
Affiliation(s)
- Cecilia Cheng
- Department of Psychology, The University of Hong Kong, Hong Kong, Hong Kong
| | - Sihui Chen
- Department of Chinese and Bilingual Studies, Hong Kong Polytechnic University, Hong Kong, Hong Kong
| | - Si Chen
- Department of Psychology, The University of Hong Kong, Hong Kong, Hong Kong
| |
Collapse
|
7
|
Kumar P, Banik SP, Ohia SE, Moriyama H, Chakraborty S, Wang CK, Song YS, Goel A, Bagchi M, Bagchi D. Current Insights on the Photoprotective Mechanism of the Macular Carotenoids, Lutein and Zeaxanthin: Safety, Efficacy and Bio-Delivery. JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION 2024; 43:505-518. [PMID: 38393321 DOI: 10.1080/27697061.2024.2319090] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/20/2023] [Revised: 02/07/2024] [Accepted: 02/11/2024] [Indexed: 02/25/2024]
Abstract
Ocular health has emerged as one of the major issues of global health concern with a decline in quality of life in an aging population, in particular and rise in the number of associated morbidities and mortalities. One of the chief reasons for vision impairment is oxidative damage inflicted to photoreceptors in rods and cone cells by blue light as well as UV radiation. The scenario has been aggravated by unprecedented rise in screen-time during the COVID and post-COVID era. Lutein and Zeaxanthin are oxygenated carotenoids with proven roles in augmentation of ocular health largely by virtue of their antioxidant properties and protective effects against photobleaching of retinal pigments, age-linked macular degeneration, cataract, and retinitis pigmentosa. These molecules are characterized by their characteristic yellow-orange colored pigmentation and are found in significant amounts in vegetables such as corn, spinach, broccoli, carrots as well as fish and eggs. Unique structural signatures including tetraterpenoid skeleton with extensive conjugation and the presence of hydroxyl groups at the end rings have made these molecules evolutionarily adapted to localize in the membrane of the photoreceptor cells and prevent their free radical induced peroxidation. Apart from the benefits imparted to ocular health, lutein and zeaxanthin are also known to improve cognitive function, cardiovascular physiology, and arrest the development of malignancy. Although abundant in many natural sources, bioavailability of these compounds is low owing to their long aliphatic backbones. Under the circumstances, there has been a concerted effort to develop vegetable oil-based carriers such as lipid nano-emulsions for therapeutic administration of carotenoids. This review presents a comprehensive update of the therapeutic potential of the carotenoids along with the challenges in achieving an optimized delivery tool for maximizing their effectiveness inside the body.
Collapse
Affiliation(s)
- Pawan Kumar
- R&D Department, Chemical Resources (CHERESO), Panchkula, India
| | - Samudra P Banik
- Department of Microbiology, Maulana Azad College, Kolkata, India
| | - Sunny E Ohia
- Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA
| | - Hiroyoshi Moriyama
- Department of Scientific Affairs, The Japanese Institute for Health Food Standards, Tokyo, Japan
| | - Sanjoy Chakraborty
- Department of Biological Sciences, New York City College of Technology/CUNY, Brooklyn, NY, USA
| | - Chin-Kun Wang
- Department of Nutrition, Chung Shan Medical University, Taichung, Taiwan
| | - Yong Sang Song
- Department of Obstetrics and Gynaecology, Seoul National University Hospital, Seoul, South Korea
| | - Apurva Goel
- Regulation Department, Chemical Resources (CHERESO), Panchkula, India
| | | | - Debasis Bagchi
- Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA
- Department of Biology, College of Arts and Sciences, and Department of Psychology, Gordon F. Derner School of Psychology, Adelphi University, Garden City, NY, USA
| |
Collapse
|
8
|
Waalkes MR, Leathery M, Peck M, Barr A, Cunill A, Hageter J, Horstick EJ. Light wavelength modulates search behavior performance in zebrafish. Sci Rep 2024; 14:16533. [PMID: 39019915 PMCID: PMC11255219 DOI: 10.1038/s41598-024-67262-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/02/2024] [Accepted: 07/09/2024] [Indexed: 07/19/2024] Open
Abstract
Visual systems have evolved to discriminate between different wavelengths of light. The ability to perceive color, or specific light wavelengths, is important as color conveys crucial information about both biotic and abiotic features in the environment. Indeed, different wavelengths of light can drive distinct patterns of activity in the vertebrate brain, yet what remains incompletely understood is whether distinct wavelengths can invoke etiologically relevant behavioral changes. To address how specific wavelengths in the visible spectrum modulate behavioral performance, we use larval zebrafish and a stereotypic light-search behavior. Prior work has shown that the cessation of light triggers a transitional light-search behavior, which we use to interrogate wavelength-dependent behavioral modulation. Using 8 narrow spectrum light sources in the visible range, we demonstrate that all wavelengths induce motor parameters consistent with search behavior, yet the magnitude of search behavior is spectrum sensitive and the underlying motor parameters are modulated in distinct patterns across short, medium, and long wavelengths. However, our data also establishes that not all motor features of search are impacted by wavelength. To define how wavelength modulates search performance, we performed additional assays with alternative wavelengths, dual wavelengths, and variable intensity. Last, we also tested blind larvae to resolve which components of wavelength dependent behavioral changes potentially include signaling from non-retinal photoreception. These findings have important implications as organisms can be exposed to varying wavelengths in laboratory and natural settings and therefore impose unique behavioral outputs.
Collapse
Affiliation(s)
- Matthew R Waalkes
- Department of Biology Morgantown, West Virginia University, Morgantown, WV, USA
| | - Maegan Leathery
- Department of Biology Morgantown, West Virginia University, Morgantown, WV, USA
| | - Madeline Peck
- Department of Biology Morgantown, West Virginia University, Morgantown, WV, USA
| | - Allison Barr
- Department of Biology Morgantown, West Virginia University, Morgantown, WV, USA
| | - Alexander Cunill
- Department of Biology Morgantown, West Virginia University, Morgantown, WV, USA
| | - John Hageter
- Department of Biology Morgantown, West Virginia University, Morgantown, WV, USA
| | - Eric J Horstick
- Department of Biology Morgantown, West Virginia University, Morgantown, WV, USA.
- Department of Neuroscience Morgantown, West Virginia University, Morgantown, WV, USA.
| |
Collapse
|
9
|
Lei T, Hua H, Du H, Xia J, Xu D, Liu W, Wang Y, Yang T. Molecular mechanisms of artificial light at night affecting circadian rhythm disturbance. Arch Toxicol 2024; 98:395-408. [PMID: 38103071 DOI: 10.1007/s00204-023-03647-5] [Citation(s) in RCA: 2] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/07/2023] [Accepted: 11/16/2023] [Indexed: 12/17/2023]
Abstract
Artificial light at night (ALAN) pollution has been regarded as a global environmental concern. More than 80% of the global population is exposed to light pollution. Exacerbating this issue, artificially lit outdoor areas are growing by 2.2% per year, while continuously lit areas have brightened by 2.2% each year due to rapid population growth and expanding urbanization. Furthermore, the increasing prevalence of night shift work and smart device usage contributes to the inescapable influence of ALAN. Studies have shown that ALAN can disrupt endogenous biological clocks, resulting in a disturbance of the circadian rhythm, which ultimately affects various physiological functions. Up until now, scholars have studied various disease mechanisms caused by ALAN that may be related to the response of the circadian system to light. This review outlines the molecular mechanisms by which ALAN causes circadian rhythm abnormalities in sleep disorders, endocrine diseases, cardiovascular disease, cancer, immune impairment, depression, anxiety and cognitive impairments.
Collapse
Affiliation(s)
- Ting Lei
- Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention (China Medical University), Ministry of Education, Shenyang, 110122, Liaoning, China
- Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, Liaoning, China
| | - Hui Hua
- Department of Nutrition, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China
- Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China
| | - Huiying Du
- Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention (China Medical University), Ministry of Education, Shenyang, 110122, Liaoning, China
- Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, Liaoning, China
| | - Jie Xia
- Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention (China Medical University), Ministry of Education, Shenyang, 110122, Liaoning, China
- Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, Liaoning, China
| | - Dandan Xu
- Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention (China Medical University), Ministry of Education, Shenyang, 110122, Liaoning, China
- Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, Liaoning, China
| | - Wei Liu
- Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention (China Medical University), Ministry of Education, Shenyang, 110122, Liaoning, China
- Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, Liaoning, China
| | - Yutong Wang
- Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China.
| | - Tianyao Yang
- Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention (China Medical University), Ministry of Education, Shenyang, 110122, Liaoning, China.
- Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, Liaoning, China.
| |
Collapse
|
10
|
An Y, Zhang MX. Relationship between problematic smartphone use and sleep problems: The roles of sleep-related compensatory health beliefs and bedtime procrastination. Digit Health 2024; 10:20552076241283338. [PMID: 39291154 PMCID: PMC11406640 DOI: 10.1177/20552076241283338] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/17/2024] [Accepted: 08/28/2024] [Indexed: 09/19/2024] Open
Abstract
Objective Concerns regarding sleep problems in emerging adults and their antecedents, such as problematic smartphone use (PSU), have been growing. This study tested the association between PSU and sleep problems and further investigated the mechanisms of this relationship based on the theory of compensatory health beliefs (CHBs). Methods This study included 999 participants (74.87% female) in China, aged 17 to 25 years (M = 21.16; standard deviation = 1.60), who voluntarily filled in an anonymous survey. Results The findings showed positive correlations between sleep problems and PSU, sleep-related CHBs, and bedtime procrastination (rs = .25-.52, p < .001). Furthermore, the positive link between PSU and sleep problems was mediated by bedtime procrastination alone (β=.21, 95% confidence interval (CI) [.17, .26]) or a serial path of sleep-related CHBs and bedtime procrastination (β=.04, 95% CI [.02, .05]). Conclusion This study provides a new perspective to understand the internal mechanism underlying the PSU-sleep problem link. Interventions for sleep disorders ought to consider the theoretical guidelines of the CHBs model to reduce the risk of bedtime procrastination and sleep disorders in emerging adults.
Collapse
Affiliation(s)
- Yandong An
- Department of Medical Humanities, School of Humanities, Southeast University, Nanjing, Jiangsu, China
- Psychological Research & Education Center, School of Humanities, Southeast University, Nanjing, Jiangsu, China
| | - Meng Xuan Zhang
- Department of Medical Humanities, School of Humanities, Southeast University, Nanjing, Jiangsu, China
- Psychological Research & Education Center, School of Humanities, Southeast University, Nanjing, Jiangsu, China
| |
Collapse
|
11
|
Candussi CJ, Kabir R, Sivasubramanian M. Problematic smartphone usage, prevalence and patterns among university students: A systematic review. JOURNAL OF AFFECTIVE DISORDERS REPORTS 2023; 14:100643. [DOI: 10.1016/j.jadr.2023.100643] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/06/2024] Open
|
12
|
Akbari M, Seydavi M, Sheikhi S, Spada MM. Problematic smartphone use and sleep disturbance: the roles of metacognitions, desire thinking, and emotion regulation. Front Psychiatry 2023; 14:1137533. [PMID: 37593452 PMCID: PMC10427798 DOI: 10.3389/fpsyt.2023.1137533] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/04/2023] [Accepted: 05/22/2023] [Indexed: 08/19/2023] Open
Abstract
Background The association between problematic Smartphone use (PSU) and sleep disturbance is evidenced in the literature, but more research is required to investigate the potential factors that may influence the effect of PSU on sleep disturbance. Given the considerable prevalence of PSU (9.3 to 36.7%) and sleep disturbance (55.2%) in Iran, the current study sought to examine an interactional model to test whether metacognitions about Smartphone use, desire thinking (verbal perseveration and imaginal prefiguration), and emotion regulation (expressive suppression and cognitive reappraisal) could have a moderating effect on the above-mentioned association. Method This present study is a cross-sectional, observational study that was conducted between June and September 2022 in a convenience sample of Iranians (n = 603, Female = 419, Age = 24.61 ± 8). Results Despite the significant association between metacognitions about the Smartphone use, PSU, and sleep disturbance, metacognitions failed to predict sleep disturbance above PSU. A slope analysis showed, however, that a high (not low or moderate) levels of imaginal prefiguration strengthen the association between PSU and sleep disturbance, while a high (not low or moderate) level of cognitive reappraisal and expressive suppression dampen the PSU-sleep disturbance association. We also found that verbal perseveration and expressive suppression were unique predictors of sleep disturbance, while imaginal prefiguration and reappraisal only predicted sleep disturbance if they interacted with PSU. Conclusion Theoretically, findings suggest that enhancing cognitive reappraisal (by 1 SD) and reducing imaginal prefiguration (by 1 SD), might protect against sleep disturbance by reducing its association with PSU. Limitations and future directions are discussed.
Collapse
Affiliation(s)
- Mehdi Akbari
- Department of Clinical Psychology, Faculty of Psychology and Education, Kharazmi University, Tehran, Iran
| | - Mohammad Seydavi
- Department of Clinical Psychology, Faculty of Psychology and Education, Kharazmi University, Tehran, Iran
| | - Sonay Sheikhi
- Department of Clinical Psychology, Faculty of Psychology and Education, Kharazmi University, Tehran, Iran
| | - Marcantonio M. Spada
- School of Applied Sciences, London South Bank University, London, United Kingdom
| |
Collapse
|
13
|
Gao WJ, Hu Y, Ji JL, Liu XQ. Relationship between depression, smartphone addiction, and sleep among Chinese engineering students during the COVID-19 pandemic. World J Psychiatry 2023; 13:361-375. [PMID: 37383286 PMCID: PMC10294134 DOI: 10.5498/wjp.v13.i6.361] [Citation(s) in RCA: 4] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/27/2023] [Revised: 04/07/2023] [Accepted: 04/24/2023] [Indexed: 06/19/2023] Open
Abstract
BACKGROUND Existing research has demonstrated that depression is positively related to smartphone addiction, but the role of sleep has not been discussed thoroughly, especially among engineering undergraduates affected by the coronavirus disease 2019 pandemic.
AIM To evaluate sleep as a mediator of the association between smartphone addiction and depression among engineering undergraduates.
METHODS Using a multistage stratified random sampling method, a cross-sectional survey was conducted among 692 engineering undergraduates from a top engineering university in China, and data were collected by self-reported electronic questionnaires. The data included demographic characteristics, such as age, gender, the Smartphone Addiction Scale-Short Version (SAS-SV), the 9-item Patient Health Questionnaire, and the Pittsburgh Sleep Quality Index. Pearson correlation and multiple linear regression analyses were used to examine the association between smartphone addiction and depression, while structural equation models were established to evaluate the possible mediating role of sleep.
RESULTS Based on the cutoffs of the SAS-SV, the rate of smartphone addiction was 63.58 percent, with 56.21 percent for women and 65.68 percent for men, among 692 engineering students. The prevalence of depression among students was 14.16 percent, with 17.65 percent for women, and 13.18 percent for men. Smartphone addiction was positively correlated with depression, and sleep played a significant mediating effect between the two, accounting for 42.22 percent of the total effect. In addition, sleep latency, sleep disturbances, and daytime dysfunction significantly mediated the relationship between depression and smartphone addiction. The mediating effect of sleep latency was 0.014 [P < 0.01; 95% confidence interval (CI): 0.006-0.027], the mediating effect of sleep disturbances was 0.022 (P < 0.01; 95%CI: 0.011-0.040), and the mediating effect of daytime dysfunction was 0.040 (P < 0.01; 95%CI: 0.024-0.059). The influence of sleep latency, sleep disturbances, and daytime dysfunction accounted for 18.42%, 28.95%, and 52.63% of the total mediating effect, respectively.
CONCLUSION The results of the study suggest that reducing excessive smartphone use and improving sleep quality can help alleviate depression.
Collapse
Affiliation(s)
- Wen-Juan Gao
- Institute of Higher Education, Beihang University, Beijing 100191, China
- School of Public Administration, Beihang University, Beijing 100191, China
- Research Center for Beijing Higher Education Development, Beihang University, Beijing 100191, China
| | - Yan Hu
- Institute of Higher Education, Beihang University, Beijing 100191, China
- School of Public Administration, Beihang University, Beijing 100191, China
- Research Center for Beijing Higher Education Development, Beihang University, Beijing 100191, China
| | - Jun-Lin Ji
- Institute of Higher Education, Beihang University, Beijing 100191, China
- School of Public Administration, Beihang University, Beijing 100191, China
- Research Center for Beijing Higher Education Development, Beihang University, Beijing 100191, China
| | - Xin-Qiao Liu
- School of Education, Tianjin University, Tianjin 300350, China
| |
Collapse
|
14
|
Stapleton F, Abad JC, Barabino S, Burnett A, Iyer G, Lekhanont K, Li T, Liu Y, Navas A, Obinwanne CJ, Qureshi R, Roshandel D, Sahin A, Shih K, Tichenor A, Jones L. TFOS lifestyle: Impact of societal challenges on the ocular surface. Ocul Surf 2023; 28:165-199. [PMID: 37062429 PMCID: PMC10102706 DOI: 10.1016/j.jtos.2023.04.006] [Citation(s) in RCA: 19] [Impact Index Per Article: 9.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/04/2023] [Accepted: 04/06/2023] [Indexed: 04/18/2023]
Abstract
Societal factors associated with ocular surface diseases were mapped using a framework to characterize the relationship between the individual, their health and environment. The impact of the COVID-19 pandemic and mitigating factors on ocular surface diseases were considered in a systematic review. Age and sex effects were generally well-characterized for inflammatory, infectious, autoimmune and trauma-related conditions. Sex and gender, through biological, socio-economic, and cultural factors impact the prevalence and severity of disease, access to, and use of, care. Genetic factors, race, smoking and co-morbidities are generally well characterized, with interdependencies with geographical, employment and socioeconomic factors. Living and working conditions include employment, education, water and sanitation, poverty and socioeconomic class. Employment type and hobbies are associated with eye trauma and burns. Regional, global socio-economic, cultural and environmental conditions, include remoteness, geography, seasonality, availability of and access to services. Violence associated with war, acid attacks and domestic violence are associated with traumatic injuries. The impacts of conflict, pandemic and climate are exacerbated by decreased food security, access to health services and workers. Digital technology can impact diseases through physical and mental health effects and access to health information and services. The COVID-19 pandemic and related mitigating strategies are mostly associated with an increased risk of developing new or worsening existing ocular surface diseases. Societal factors impact the type and severity of ocular surface diseases, although there is considerable interdependence between factors. The overlay of the digital environment, natural disasters, conflict and the pandemic have modified access to services in some regions.
Collapse
Affiliation(s)
- Fiona Stapleton
- School of Optometry and Vision Science, UNSW, Sydney, NSW, Australia.
| | - Juan Carlos Abad
- Department of Ophthalmology, Antioquia Ophthalmology Clinic-Clofan, Medellin, Antioquia, Colombia
| | - Stefano Barabino
- ASST Fatebenefratelli-Sacco, Ospedale L. Sacco-University of Milan, Milan, Italy
| | - Anthea Burnett
- School of Optometry and Vision Science, UNSW, Sydney, NSW, Australia
| | - Geetha Iyer
- C. J. Shah Cornea Services, Sankara Nethralaya, Chennai, Tamil Nadu, India
| | - Kaevalin Lekhanont
- Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
| | - Tianjing Li
- Department of Ophthalmology, School of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA
| | - Yang Liu
- Ophthalmology Department, Zhongnan Hospital of Wuhan University, Wuhan, China
| | - Alejandro Navas
- Conde de Valenciana, National Autonomous University of Mexico UNAM, Mexico City, Mexico
| | | | - Riaz Qureshi
- Department of Ophthalmology, School of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA
| | - Danial Roshandel
- Centre for Ophthalmology and Visual Science (incorporating Lions Eye Institute), The University of Western Australia, Nedlands, WA, Australia
| | - Afsun Sahin
- Department of Ophthalmology, Koc University Medical School, İstanbul, Turkey
| | - Kendrick Shih
- Department of Ophthalmology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
| | - Anna Tichenor
- School of Optometry, Indiana University, Bloomington, IN, USA
| | - Lyndon Jones
- Centre for Ocular Research & Education (CORE), School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada
| |
Collapse
|
15
|
Mohideen A, Bouvin C, Judah G, Picariello F, Gardner B. Feasibility and acceptability of a personalised script-elicitation method for improving evening sleep hygiene habits. Health Psychol Behav Med 2023; 11:2162904. [PMID: 36618889 PMCID: PMC9815428 DOI: 10.1080/21642850.2022.2162904] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/03/2023] Open
Abstract
Background Attempts to improve evening sleep hygiene have overlooked that sleep preparation behaviours are often undertaken automatically with little awareness; that is, habitually. This mixed-methods study assessed aspects of the feasibility and acceptability of a novel behavioural intervention procedure ('script elicitation'), which encourages reflection on and reorganisation of the content and sequencing of habitual evening pre-sleep routines. Methods The study was advertised via social media, and circular lists at a UK university. Twenty-four UK-based adults, reporting <6 h/night sleep, were recruited. At baseline, they completed sleep hygiene and quality measures, then participated in an online, one-to-one script elicitation interview. This involved the interviewer working with the participant to generate a fine-grained description of the content, organisation and variability of their typical pre-sleep routine, and plan a more sleep-conducive alternative routine to follow over the next week. One week later, participants completed sleep quality and hygiene measures, and a semi-structured interview about the intervention. Feasibility was assessed using quantitative data on response rates and attrition, and acceptability via sleep hygiene and quality scores, and qualitative data on intervention experiences. Results All criteria were met. The target response rate was exceeded, none of the 24 participants dropped out, and sleep hygiene and quality scores either improved or remained stable. In interviews, all participants reported finding script elicitation useful. Script elicitation raised participants' awareness of habitual sleep hygiene routines, which gave many a newfound sense of autonomy over changing their sleep hygiene habits. While the habitual nature of existing routines obstructed change for some participants, most reported successfully changing aspects of their routine, and achieving behaviour, sleep and wellbeing improvements. Discussion Script elicitation is a promising and acceptable method for tackling poor evening sleep hygiene habits. A more rigorous trial is warranted.
Collapse
Affiliation(s)
- Anya Mohideen
- Department of Psychology, King's College London, London, UK
| | - Clara Bouvin
- Department of Psychology, King's College London, London, UK
| | - Gaby Judah
- Patient Safety Translational Research Centre, Imperial College London, London, UK
| | | | - Benjamin Gardner
- Department of Psychology, King's College London, London, UK,Department of Psychology, University of Surrey, Guildford, UK, Benjamin Gardner Department of Psychology, University of Surrey, Elizabeth Fry Building, GuildfordGU2 7XH, UK
| |
Collapse
|
16
|
Huang PC, Hung CH, Chen GW, Cashin C, Griffiths MD, Yang WC, Wang HW, Lin CY, Ko NY. COVID-19-Related Self-Stigma, Post-Traumatic Stress Disorder, Insomnia, and Smartphone Addiction Among Frontline Government Workers with COVID-19 Pandemic Control Duties. Psychol Res Behav Manag 2022; 15:3069-3080. [PMID: 36281271 PMCID: PMC9587721 DOI: 10.2147/prbm.s383842] [Citation(s) in RCA: 13] [Impact Index Per Article: 4.3] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/26/2022] [Accepted: 09/27/2022] [Indexed: 11/22/2022] Open
Abstract
Purpose The duties related to COVID-19 control and prevention may have caused psychological stress for the individuals in charge (eg, frontline government workers) and have reportedly led to mental health issues, such as insomnia and post-traumatic stress disorder (PTSD). However, the prevalence of these COVID-19-related disorders and their associated factors remain unclear. Therefore, the purpose of the present study was to investigate the prevalence rates of insomnia, PTSD, COVID-19-related self-stigma, and smartphone addiction, along with the identification of risk factors and protective factors for Taiwan frontline government workers with COVID-19 pandemic control duties. Methods The survey was carried out with 151 participants between September and October 2021. All participants completed the Fear of COVID-19 Scale (assessing fear of COVID-19), Self-Stigma Scale (assessing self-stigma during the COVID-19 pandemic), Smartphone Application-Based Addiction Scale (assessing the risk of smartphone addiction), Insomnia Severity Index (assessing insomnia), Impacts of Event Scale-6 (assessing PTSD), and a self-designed set of questions assessing trait resilience. Results The results showed that the prevalence rate was 31.1% for insomnia and 33.8% for PTSD. Furthermore, service duration (adjusted odds ratio [AOR] = 0.93; 95% confidence interval [CI] = 0.86, 0.999) and trait resilience (AOR = 0.19; 95% CI = 0.08, 0.46) were protective factors and fear of COVID-19 (AOR = 1.91; 95% CI = 1.02, 3.57) was a risk factor for insomnia. Fear of COVID-19 (AOR = 2.63; 95% CI = 1.35, 5.14), self-stigma (AOR = 3.62; 95% CI = 1.19, 11.02), and smartphone addiction (AOR = 1.09, 95% CI = 1.001, 1.19) were risk factors, and trait resilience was a protective factor (AOR = 0.58; 95% CI = 0.29, 1.17) for PTSD. Conclusion The findings demonstrated a high prevalence of insomnia and PTSD. Risk-reducing strategies and protective factor promotion strategies are recommended to help reduce the symptoms of insomnia and PTSD among Taiwan frontline government workers.
Collapse
Affiliation(s)
- Po-Ching Huang
- Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
| | - Ching-Hsia Hung
- Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
- Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan
| | - Guan-Wei Chen
- Department of Hydraulic and Ocean Engineering, College of Engineering, National Cheng Kung University, Tainan, Taiwan
| | - Ciaran Cashin
- Department of Hydraulic and Ocean Engineering, College of Engineering, National Cheng Kung University, Tainan, Taiwan
| | - Mark D Griffiths
- International Gaming Research Unit, Psychology Department, Nottingham Trent University, Nottingham, UK
| | - Wen-Chi Yang
- Division of Hematology and Medical Oncology, Department of Internal Medicine, E-DA Hospital, Kaohsiung, Taiwan
- Faculty of School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan
| | - Hsiao-Wen Wang
- Department of Hydraulic and Ocean Engineering, College of Engineering, National Cheng Kung University, Tainan, Taiwan
| | - Chung-Ying Lin
- Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
- Biostatistics Consulting Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
- Department of Occupational Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan
- Department of Public Health, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
| | - Nai-Ying Ko
- Department of Nursing, College of Medicine, National Cheng Kung University, Tainan, Taiwan
| |
Collapse
|
17
|
Preschoolers' engagement with screen content and associations with sleep and cognitive development. Acta Psychol (Amst) 2022; 230:103762. [DOI: 10.1016/j.actpsy.2022.103762] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/07/2022] [Revised: 08/19/2022] [Accepted: 10/03/2022] [Indexed: 11/18/2022] Open
|
18
|
Sadraeian M, Zhang L, Aavani F, Biazar E, Jin D. Viral inactivation by light. ELIGHT 2022; 2:18. [PMID: 36187558 PMCID: PMC9510523 DOI: 10.1186/s43593-022-00029-9] [Citation(s) in RCA: 11] [Impact Index Per Article: 3.7] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 07/08/2022] [Revised: 09/03/2022] [Accepted: 09/07/2022] [Indexed: 11/28/2022]
Abstract
Nowadays, viral infections are one of the greatest challenges for medical sciences and human society. While antiviral compounds and chemical inactivation remain inadequate, physical approaches based on irradiation provide new potentials for prevention and treatment of viral infections, without the risk of drug resistance and other unwanted side effects. Light across the electromagnetic spectrum can inactivate the virions using ionizing and non-ionizing radiations. This review highlights the anti-viral utility of radiant methods from the aspects of ionizing radiation, including high energy ultraviolet, gamma ray, X-ray, and neutron, and non-ionizing photo-inactivation, including lasers and blue light.
Collapse
Affiliation(s)
- Mohammad Sadraeian
- Present Address: Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, NSW 2007 Australia
| | - Le Zhang
- Present Address: Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, NSW 2007 Australia
| | - Farzaneh Aavani
- Department of Oral and Maxillofacial Surgery, Division of Regenerative Orofacial Medicine, University Hospital Hamburg-Eppendorf, 20251 Hamburg, Germany
| | - Esmaeil Biazar
- Department of Biomedical Engineering, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran
| | - Dayong Jin
- Present Address: Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, NSW 2007 Australia
- UTS-SUStech Joint Research Centre for Biomedical Materials & Devices, Department of Biomedical Engineering, College of Engineering, Southern University of Science and Technology, Shenzhen, Guangdong China
| |
Collapse
|
19
|
Liu M, Lu C. Mobile phone addiction and depressive symptoms among Chinese University students: The mediating role of sleep disturbances and the moderating role of gender. Front Public Health 2022; 10:965135. [PMID: 36203678 PMCID: PMC9531624 DOI: 10.3389/fpubh.2022.965135] [Citation(s) in RCA: 9] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/09/2022] [Accepted: 08/31/2022] [Indexed: 01/24/2023] Open
Abstract
Background With the continuous updating of mobile phone functions, the phenomenon of mobile phone addiction among University students is becoming more and more serious. It is important to identify the potential risk factors for mobile phone addiction. The aim of the study was to examine whether there is a relationship between mobile phone addiction and depression symptoms in University students, and to investigate whether sleep disturbances play a mediating role between mobile phone addiction and depression symptoms, as well as the moderating role of gender. Methods A cross-sectional study, carried out between September to December 2021, recruited 973 students (478 males) from seven comprehensive universities in western China. The Mobile Phone Addiction Index (MPAI), the Patient Health Questionnaire-9 (PHQ9), and the Pittsburgh Sleep Quality Index (PSQI) were used to complete measures of mobile phone addiction, depressive symptoms, and sleep disturbances. For statistical analyses, descriptive statistics, correlation, regression, mediation and moderated mediation analyses were used. Furthermore, we tested the mediation model and moderated mediation model using the SPSS macro PROCESS. Results In this study, it was found that there were positive correlations between mobile phone addiction and depressive symptoms among Chinese University students. Mediation analyses revealed that this relationship was partially mediated by sleep disturbances, but the mediating role was not moderated by gender. Conclusion Sleep disturbances have a partial mediating role in the relationship between mobile phone addiction and depressive symptoms. Our results highlight the critical role of prevention and early identification of mobile phone addiction among University students, especially those with sleep disturbances.
Collapse
|
20
|
Lee S, Kim S, Yang S, Shin Y. Effects of Frequent Smartphone Use on Sleep Problems in Children under 7 Years of Age in Korea: A 4-Year Longitudinal Study. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2022; 19:10252. [PMID: 36011886 PMCID: PMC9408342 DOI: 10.3390/ijerph191610252] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 06/27/2022] [Revised: 08/06/2022] [Accepted: 08/13/2022] [Indexed: 06/15/2023]
Abstract
The use of electronic screen devices has a negative effect on sleep. The purpose of this study is to longitudinally examine the effects of various screen use on sleep problems in children under 7 years of age. A total of 314 caregivers of children aged 4−7 years from three cities in Korea were recruited and responded to a self-administered questionnaire from 2017 to 2020. As a result of the analysis of the mixed model designed as a two-leveled structure, the use frequency of smartphones significantly predicted children’s sleep problems (β = 0.328, p < 0.001) compared to that of TV, PC, and tablet PC. In addition, the frequency of smartphone screen use showed a weak but significant correlation with bedtime resistance (r = 0.067, p = 0.009), sleep duration (r = 0.089, p <0.001), nighttime awakening (r = 0.066, p = 0.010), and daytime sleepiness (r = 0.102, p < 0.001). The results of this study suggest that screen time education in Korea should focus on smartphones above all else.
Collapse
Affiliation(s)
- Sangha Lee
- Department of Psychiatry, Ajou University School of Medicine, Suwon 16500, Korea
| | - Sungju Kim
- Department of Psychiatry, Ajou University School of Medicine, Suwon 16500, Korea
| | - Sujin Yang
- Gwangju Smile Center for Crime Victims, Gwangju 61480, Korea
| | - Yunmi Shin
- Department of Psychiatry, Ajou University School of Medicine, Suwon 16500, Korea
| |
Collapse
|
21
|
Gourzoulidis GA, Karabetsos E, Bourousis C, Tyrakis C, Flouris AD, Maris TG, Topalis FV. Occupational electromagnetic spectrum hazards and the significance of artificial optical radiation: country report for Greece. LA MEDICINA DEL LAVORO 2022; 113:e2022016. [PMID: 35481582 PMCID: PMC9073759 DOI: 10.23749/mdl.v113i2.12636] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 12/02/2021] [Accepted: 03/01/2022] [Indexed: 11/17/2022]
Abstract
BACKGROUND The electromagnetic spectrum spans over an enormous range from 0 up to more than 1020 Hz in the deep ionizing region, significant exposures exist in specific occupational environments. Between the ionizing and the electromagnetic fields (EMF) part of the spectrum, the 'optical radiation' (OR) region has specific properties. Comparative and concise evaluation enables action prioritization. METHODS Following the transposition and implementation periods of the artificial optical radiation (AOR) and EMF European Directives, the Hellenic Ministry of Labour in collaboration with the Greek Atomic Energy Commission (EEAE) and the National Technical University of Athens, conducted thorough occupational exposure investigation in Greece. Using dedicated measuring equipment and procedures, the majority of EMF emitting installations in Greece and also AOR emitting installations including arc welding, lasers and PC monitors has been assessed. RESULTS Measurement results from occupational settings reveal that it is the non-coherent metal arc welding AOR that can pose even sub-second overexposures. Rare EMF overexposures are manageable and EMF concern is not justified. Maintenance procedures demand proper attention. Preliminary laser safety assessment reveals OHS gaps and potential eye and skin hazards. Blue light exposure from computer monitors is well below safety limits. CONCLUSIONS This electromagnetic spectrum risk assessment conducted in Greece enables the justification of the real occupational hazards, in this sense: i) EMF exposure assessment has to be concentrated to maintenance procedures; ii) AOR measuring setups are challenging and standardized measurement procedures are missing, and iii) AOR overexposures from arc welding pose significant eye and skin hazards.
Collapse
|
22
|
Calderon-Jofre R, Moraga D, Moraga FA. The Effect of Chronic Intermittent Hypobaric Hypoxia on Sleep Quality and Melatonin Serum Levels in Chilean Miners. Front Physiol 2022; 12:809360. [PMID: 35222064 PMCID: PMC8864145 DOI: 10.3389/fphys.2021.809360] [Citation(s) in RCA: 6] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/04/2021] [Accepted: 12/22/2021] [Indexed: 11/13/2022] Open
Abstract
High-altitude mining is an important economic resource for Chile. These workers are exposed to chronic intermittent hypobaric hypoxia (CIHH), which reduces their sleep quality and increases the risk of accidents and long-term illnesses. Melatonin, a hormone produced by the pineal gland, is a sleep inducer that regulates the circadian cycle and may be altered in populations subjected to CIHH. This work aimed to assess the relationship between altitude, sleep quality, and plasma melatonin concentrations in miners with CIHH exposure. 288 volunteers were recruited from five altitudes (0, 1,600, 2,500, 3,500, and 4,500 m). All volunteers worked for 7 days at altitude, followed by 7 days of rest at sea level. We performed anthropometric assessments, nocturnal oximetry, sleep quality and sleepiness surveys, and serum melatonin levels upon awakening. Although oxygen saturation progressively decreased and heart rate increased at higher altitudes, subjective perception of sleep quality was not significantly different, and sleepiness increased in all groups compared to population at sea level. Similarly, melatonin levels increased at all assessed altitudes compared to the population at sea level. These data confirm that sleep disturbances associated with CIHH increase morning melatonin levels. Therefore, this hormone and could potentially serve as a biomarker of sleep quality.
Collapse
Affiliation(s)
- Rodrigo Calderon-Jofre
- Laboratorio de Fisiología, Hipoxia y Función Vascular, Departamento de Ciencias Biomédicas, Facultad de Medicina, Universidad Católica del Norte, Coquimbo, Chile
| | - Daniel Moraga
- Departamento de Medicina, Facultad de Ciencias de la Salud, Universidad de Tarapacá, Arica, Chile
| | - Fernando A. Moraga
- Departamento de Medicina, Facultad de Ciencias de la Salud, Universidad de Tarapacá, Arica, Chile
- *Correspondence: Fernando A. Moraga,
| |
Collapse
|
23
|
Upadhyay D, Mehta K, Mahajan N, Jadeja T, Sevak R. Evaluation of smartphone usage as a predictor of social jetlag in university students. ANNALS OF INDIAN PSYCHIATRY 2022. [DOI: 10.4103/aip.aip_24_22] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/04/2022] Open
|
24
|
Supit A, Gosal M, Mamuaja P, Kumaat S, Paturusi A. Later Chronotype Correlates With Severe Depression in Indonesian College Students. SLEEP MEDICINE RESEARCH 2021. [DOI: 10.17241/smr.2021.00969] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/12/2022] Open
Abstract
Background and Objective The correlation between late chronotype and depression has been well documented, but reports from the equatorial area, where the sun shines throughout the year with less seasonal variation, are limited. In the present research study, we sought to 1) examine the relationship between the chronotype and mental health symptoms in an Indonesian student population and 2) explore the characteristics of those who lie at the extreme chronotype and psychometry.Methods This is a cross-sectional questionnaire-based study including undergraduate students in an Indonesian university (n = 493). We used the Munich Chronotype Questionnaires and the Depression, Anxiety, and Stress Scale to assess the chronotype and mental symptoms, respectively. Following this, a follow-up with an in-depth interview on the selected population at the extreme end of the chronotype was performed as an exploratory approach to identify their common characteristics.Results Among the tested parameters, the depression score was significantly associated with chronotype (p = 0.003), replicating previous findings from other areas with higher latitudes. The correlation persisted when males and females were analyzed separately (p = 0.008 and 0.037, respectively). A follow-up qualitative analysis revealed a potential subclinical, unrealized depression among the subjects; our findings revealed the use of smartphones during or before bedtime as a common factor among those with later chronotypes.Conclusions There is a correlation between depression score and chronotype among Indonesian college students, where subjects with later chronotype are more likely to have a higher depression score.
Collapse
|
25
|
Light at night disrupts biological clocks, calendars, and immune function. Semin Immunopathol 2021; 44:165-173. [PMID: 34731290 PMCID: PMC8564795 DOI: 10.1007/s00281-021-00899-0] [Citation(s) in RCA: 28] [Impact Index Per Article: 7.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/26/2021] [Accepted: 10/13/2021] [Indexed: 12/15/2022]
Abstract
Light at night is a pervasive problem in our society; over 80% of the world’s population experiences significant light pollution. Exacerbating this issue is the reality that artificially lit outdoor areas are growing by 2.2% per year and continuously lit areas brighten by 2.2% each year due to the rapid growths in population and urbanization. Furthermore, the increase in the prevalence of night shift work and smart device usage contributes to the inescapable nature of artificial light at night (ALAN). Although previously assumed to be innocuous, ALAN has deleterious effects on the circadian system and circadian-regulated physiology, particularly immune function. Due to the relevance of ALAN to the general population, it is important to understand its roles in disrupting immune function. This review presents a synopsis of the effects of ALAN on circadian clocks and immune function. We delineate the role of ALAN in altering clock gene expression and suppressing melatonin. We review the effects of light at night on inflammation and the innate and adaptive immune systems in various species to demonstrate the wide range of ALAN consequences. Finally, we propose future directions to provide further clarity and expansion of the field.
Collapse
|
26
|
Parnell AA, De Nobrega AK, Lyons LC. Translating around the clock: Multi-level regulation of post-transcriptional processes by the circadian clock. Cell Signal 2021; 80:109904. [PMID: 33370580 PMCID: PMC8054296 DOI: 10.1016/j.cellsig.2020.109904] [Citation(s) in RCA: 16] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/15/2020] [Revised: 12/20/2020] [Accepted: 12/21/2020] [Indexed: 12/11/2022]
Abstract
The endogenous circadian clock functions to maintain optimal physiological health through the tissue specific coordination of gene expression and synchronization between tissues of metabolic processes throughout the 24 hour day. Individuals face numerous challenges to circadian function on a daily basis resulting in significant incidences of circadian disorders in the United States and worldwide. Dysfunction of the circadian clock has been implicated in numerous diseases including cancer, diabetes, obesity, cardiovascular and hepatic abnormalities, mood disorders and neurodegenerative diseases. The circadian clock regulates molecular, metabolic and physiological processes through rhythmic gene expression via transcriptional and post-transcriptional processes. Mounting evidence indicates that post-transcriptional regulation by the circadian clock plays a crucial role in maintaining tissue specific biological rhythms. Circadian regulation affecting RNA stability and localization through RNA processing, mRNA degradation, and RNA availability for translation can result in rhythmic protein synthesis, even when the mRNA transcripts themselves do not exhibit rhythms in abundance. The circadian clock also targets the initiation and elongation steps of translation through multiple pathways. In this review, the influence of the circadian clock across the levels of post-transcriptional, translation, and post-translational modifications are examined using examples from humans to cyanobacteria demonstrating the phylogenetic conservation of circadian regulation. Lastly, we briefly discuss chronotherapies and pharmacological treatments that target circadian function. Understanding the complexity and levels through which the circadian clock regulates molecular and physiological processes is important for future advancement of therapeutic outcomes.
Collapse
Affiliation(s)
- Amber A Parnell
- Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA
| | - Aliza K De Nobrega
- Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA
| | - Lisa C Lyons
- Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA.
| |
Collapse
|
27
|
Screen time duration and timing: effects on obesity, physical activity, dry eyes, and learning ability in elementary school children. BMC Public Health 2021; 21:422. [PMID: 33639912 PMCID: PMC7916284 DOI: 10.1186/s12889-021-10484-7] [Citation(s) in RCA: 21] [Impact Index Per Article: 5.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/23/2020] [Accepted: 02/22/2021] [Indexed: 12/27/2022] Open
Abstract
Background As internet use becomes more widespread, the screen time (ST) of elementary school students increases yearly. It is known that longer durations of ST can affect obesity, physical activity, dry eye disease, and learning ability. However, the effects of ST just before bedtime have not been clarified. Therefore, we examined ST duration and timing effects on elementary school children. Methods We conducted a survey of 7419 elementary school students in Tokyo, Japan using a questionnaire on food education. ST duration and timing (just before bedtime) served as the explanatory variables, and the relationship between obesity, physical activity, dry eyes, and learning ability was analyzed using logistic regression analysis. Gender, school year, height, and weight were considered confounding factors. First, we examined whether ST duration and timing were related to each objective variable, using a univariate model to examine all variables. Thereafter, we performed multivariate logistic regression analyses for all variables showing a significant difference in the univariate models. Results A significant association was observed between ST duration and obesity, physical activity, and academic performance, indicating that a longer ST duration may lead to obesity, decreased physical activity, and decreased academic performance. ST timing was associated with obesity, dry eyes, and academic performance, and ST immediately before bedtime contributed to obesity, dry eyes, and reduced academic performance. Furthermore, the results of investigating the combined effect of ST duration and timing (immediately before bedtime) on these factors revealed that ST timing has a greater effect on dry eyes, and ST duration has a greater effect on academic performance. Conclusion Our findings indicate that ST in school children is related to obesity, physical activity, dry eyes, and learning ability, and they suggest that not only the duration but also the timing of ST is important. Supplementary Information The online version contains supplementary material available at 10.1186/s12889-021-10484-7.
Collapse
|
28
|
Venkatesh Bharathi N, Jeyakumaran T, Ramaswamy S, Jayabalakrishnan SS. Synthesis and characterization of a Eu 3+ -activated Ba 2-x V 2 O 7 :xEu 3+ phosphor using a hydrothermal method: a potential material for near-UV-WLED applications. LUMINESCENCE 2021; 36:849-859. [PMID: 33569861 DOI: 10.1002/bio.4031] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/21/2020] [Revised: 01/19/2021] [Accepted: 02/08/2021] [Indexed: 12/17/2022]
Abstract
Eu3+ -activated Ba2 V2 O7 (Ba2-x V2 O7 :xEu3+ ) phosphor materials were synthesized using a hydrothermal method and different concentrations of europium (x = 0.01, 0.02, 0.03, 0.04, and 0.05%). Phase purity, structural, morphological, optical, and luminescence characteristics of the as-synthesized phosphors were studied using powder X-ray diffraction (XRD), high resolution scanning electron microscopy, UV-visible spectroscopy, and fluorescence spectrometry. The recorded XRD patterns of the as-synthesized phosphors were indexed and predicted to be a triclinic structure. A cube-like morphology was obtained for the as-prepared samples. Broad absorption in the UV region from 200 nm to 380 nm was observed and the good transparency in the visible region at 400-800 nm originated from the [VO4 ]3- group charge transfer (CT) transition. The broad emission peak centred at 499 nm was due to the CT band of the [VO4 ]3- group. Also, a sharp peak observed at 613 nm was due to the electric dipole transition of 5 D0 →7 F2 of Eu3+ ions that occupied the lattice sites without inversion symmetry for all concentrations. The colour qualities of the as-prepared samples were calculated using Commission International de l'Eclairage coordinates. The colour-rending index (CRI) value was 86 for the Ba1.97 V2 O7 :0.03Eu3+ phosphor. Furthermore, a WLED with a high CRI value of 95 was achieved by coupling the 3 W 356 nm near-UV light-emitting diode (LED) chip with the Ba2-x V2 O7 :xEu3+ phosphor. These results suggested that the as-prepared phosphor materials are potential candidates for fabrication of near-UV chip excited WLEDs.
Collapse
Affiliation(s)
- N Venkatesh Bharathi
- PG and Research Department of Physics, NMSSVN College, Madurai, Tamilnadu, India
| | - T Jeyakumaran
- PG and Research Department of Physics, NMSSVN College, Madurai, Tamilnadu, India
| | - S Ramaswamy
- PG and Research Department of Physics, NMSSVN College, Madurai, Tamilnadu, India
| | | |
Collapse
|
29
|
Winkler A, Jeromin F, Doering BK, Barke A. Problematic smartphone use has detrimental effects on mental health and somatic symptoms in a heterogeneous sample of German adults. COMPUTERS IN HUMAN BEHAVIOR 2020. [DOI: 10.1016/j.chb.2020.106500] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/13/2023]
|
30
|
Eo YJ, Kim S, Lee KN, Kim DH, Kim C, Lee SM, Do YR. WITHDRAWN: Development of a circadian illuminometer to measure the intra-daily non-visual circadian illuminance. Biosens Bioelectron 2020. [DOI: 10.1016/j.bios.2020.112688] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/23/2022]
|
31
|
Krishnan B, Sanjeev RK, Latti RG. Quality of Sleep Among Bedtime Smartphone Users. Int J Prev Med 2020; 11:114. [PMID: 33088442 PMCID: PMC7554597 DOI: 10.4103/ijpvm.ijpvm_266_19] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/17/2019] [Accepted: 01/17/2020] [Indexed: 11/04/2022] Open
Abstract
Background Exposure to light from viewing devices at night disturbs the circadian rhythm, especially sleep. The study aimed to assess (a) extent to which smart phones are used by medical undergraduate students during bedtime and to find their quality of sleep (b) the association of quality of sleep and cell phone variables. Methods A cross sectional observational study was conducted among 450 medical undergraduate students. The participants completed Pittsburgh Sleep Quality Index (PSQI) questionnaire and a validated semi structured questionnaire consisting of demographic details and cell phone variables. Results By dividing the subjects into three groups according to their usage (Group I <1 hour, Group II 1 to 2 hours, Group III >2 hours), Group III respondents had significant prolonged sleep latency, reduced sleep duration, sleep inefficiency and daytime sleep disturbances (P < 0.05). Lack of awareness about night shift mode, lying posture use while using phone during bedtime correlated with poor quality sleep (P < 0.05). Conclusions Awareness about the negative impact of evening exposure to viewing devices on sleep and health should be emphasized.
Collapse
Affiliation(s)
- Bindu Krishnan
- Department of Physiology, Rural Medical College, Loni, Pravara, Maharashtra, India
| | - Rama Krishna Sanjeev
- Department of Pediatrics, Rural Medical College, Loni, Pravara, Maharashtra, India
| | - R G Latti
- Department of Physiology, Rural Medical College, Loni, Pravara, Maharashtra, India
| |
Collapse
|
32
|
Dong K, Goyarts EC, Pelle E, Trivero J, Pernodet N. Blue light disrupts the circadian rhythm and create damage in skin cells. Int J Cosmet Sci 2020; 41:558-562. [PMID: 31418890 DOI: 10.1111/ics.12572] [Citation(s) in RCA: 32] [Impact Index Per Article: 6.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/12/2018] [Accepted: 08/12/2019] [Indexed: 12/22/2022]
Abstract
On a daily basis, the skin is exposed to many environmental stressors and insults. Over a 24-h natural cycle, during the day, the skin is focused on protection; while at night, the skin is focused on repairing damage that occurred during daytime and getting ready for the next morning. Circadian rhythm provides the precise timing mechanism for engaging those different pathways necessary to keep a healthy skin through clock genes that are present in all skin cells. The strongest clue for determining cellular functions timing is through sensing light or absence of light (darkness). Here, we asked the question if blue light could be a direct entrainment signal to skin cells and also disrupt their circadian rhythm at night. Through a reporter assay for per1 transcription, we demonstrate that blue light at 410 nm decreases per1 transcription in keratinocytes, showing that epidermal skin cells can sense light directly and control their own clock gene expression. This triggers cells to "think" it is daytime even at nighttime. Elsewhere, we measured different skin cell damage because of blue light exposure (at different doses and times of exposure) vs. cells that were kept in full darkness. We show an increase in ROS production, DNA damage and inflammatory mediators. These deleterious effects can potentially increase overall skin damage over time and ultimately accelerates ageing.
Collapse
Affiliation(s)
- K Dong
- Estee Lauder Research Laboratories, 125 Pinelawn Road, Melville, NY, 11747, USA
| | - E C Goyarts
- Estee Lauder Research Laboratories, 125 Pinelawn Road, Melville, NY, 11747, USA
| | - E Pelle
- Estee Lauder Research Laboratories, 125 Pinelawn Road, Melville, NY, 11747, USA.,Environmental Medicine, New York University School of Medicine, 341 East 25th Street, New York,, NY, 10010, USA
| | - J Trivero
- Estee Lauder Research Laboratories, 125 Pinelawn Road, Melville, NY, 11747, USA
| | - N Pernodet
- Estee Lauder Research Laboratories, 125 Pinelawn Road, Melville, NY, 11747, USA.,Materials Science & Engineering, Stony Brook University, 100 Nicolls Road, Stony Brook,, NY, 11794, USA
| |
Collapse
|
33
|
Huang YC, Hu SC, Shyu LY, Yeh CB. Increased problematic smartphone use among children with attention-deficit/hyperactivity disorder in the community: The utility of Chinese version of Smartphone Addiction Proneness Scale. J Chin Med Assoc 2020; 83:411-416. [PMID: 32235260 DOI: 10.1097/jcma.0000000000000278] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/26/2022] Open
Abstract
BACKGROUND Problematic smartphone use is more prevalent in children than before. This study aimed to evaluate the reliability and validity of the Chinese version of the Smartphone Addiction Proneness Scale (SAPS). METHODS We recruited 319 students aged 9 to 12 years including 70 attention-deficit/hyperactivity disorder subjects at a university hospital and 249 controls from elementary school. Finally, 164 males and 138 females were collected for data analysis with mean age of 10.99 ± 0.88 years. Item analysis, exploratory factor analysis, internal consistency test, and t test were performed to verify the reliability and validity of the SAPS-Chinese version. Correlations were examined for relation between the score in the SAPS-Chinese version and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition diagnostic criteria. RESULTS Factor analysis showed two factors: problematic use-associated behaviors and impaired daily functions. Item analysis for every item in the SAPS-Chinese version showed significant differences in t values (p < 0.001) and high correlation in all items (r = 0.37-0.79). The Kaiser-Meyer-Olkin (KMO) was equal to 0.94 and Bartlett's test of Sphericity was significant (p < 0.001). Cronbach's α for the SAPS-Chinese version was 0.93. It revealed high reliability and validity. CONCLUSION The SAPS-Chinese version is reliable, valid, and suitable for clinical and research uses with satisfactory properties. Applying the modified SAPS-Chinese version offers early detection of problematic smartphone use.
Collapse
Affiliation(s)
- Yu-Chieh Huang
- Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
| | - Sz-Chi Hu
- Department of Psychology, Soochow University, Taipei, Taiwan, ROC
| | - Li-Yu Shyu
- Department of Psychology, Soochow University, Taipei, Taiwan, ROC
| | - Chin-Bin Yeh
- Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
| |
Collapse
|
34
|
Mac Cárthaigh S, Griffin C, Perry J. The relationship between sleep and problematic smartphone use among adolescents: A systematic review. DEVELOPMENTAL REVIEW 2020. [DOI: 10.1016/j.dr.2020.100897] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/13/2022]
|
35
|
Evaluation of Two Strategies for Alleviating the Impact on the Circadian Cycle of Smartphone Screens. Optom Vis Sci 2020; 97:207-217. [DOI: 10.1097/opx.0000000000001485] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/06/2023] Open
|
36
|
Yao Q, Zhang L, Dai Q, Wang Y, Wu P. Chromaticity-based real-time assessment of melanopic and luminous efficiency of smartphone displays. OPTICS EXPRESS 2020; 28:4898-4910. [PMID: 32121720 DOI: 10.1364/oe.384884] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/06/2019] [Accepted: 01/30/2020] [Indexed: 06/10/2023]
Abstract
We investigate the spectral power distributions of 54 phones (33 measured experimentally in default text mode and 21 downloaded from the web) and estimate the mean ± std. dev. of the luminous efficiency of radiation, melanopic efficiency of radiation, and melanopic/photopic ratio as 287 ± 13 lm/W, 303 ± 26 blm/W, and 1.06 ± 0.13, respectively. We establish the chromaticity-performance characteristics relation to precisely assess the action efficiency of radiation performance using either RGB gray values or CIE xy values. Our real-time assessment of smartphone displays can aid in reducing energy consumption and improving user health.
Collapse
|
37
|
Yang J, Fu X, Liao X, Li Y. Association of problematic smartphone use with poor sleep quality, depression, and anxiety: A systematic review and meta-analysis. Psychiatry Res 2020; 284:112686. [PMID: 31757638 DOI: 10.1016/j.psychres.2019.112686] [Citation(s) in RCA: 121] [Impact Index Per Article: 24.2] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/12/2019] [Revised: 11/08/2019] [Accepted: 11/09/2019] [Indexed: 12/13/2022]
Abstract
To quantitatively assess the association of problematic smartphone use (PSU) with poor sleep quality, depression, and anxiety, we reviewed current evidence from observational studies and performed a systematic review and meta-analysis. The EBSCO PsycARTICLES, EMBASE, PubMed and Web of Science databases were searched, and 14 studies were included for the systematic review and meta-analysis. We calculated odds risk and 95% confidence intervals (CIs), using random-effect or fixed-effect models. Heterogeneity was assessed using I2 and chi2 statistics. Subgroup analyses were conducted based on country, adjusted variables, the methods of statistical analysis, outcome measures and publication year. We found significantly increased risks of poor sleep quality, depression, and anxiety in people with PSU. Our findings highlight the necessity of managing the PSU. However, further studies are required to confirm the results due to the high heterogeneity and methodological limitations.
Collapse
Affiliation(s)
- Jiaxin Yang
- XiangYa Nursing School, Central South University, Changsha, Hunan, China
| | - Xi Fu
- XiangYa Nursing School, Central South University, Changsha, Hunan, China
| | - Xiaoli Liao
- XiangYa Nursing School, Central South University, Changsha, Hunan, China
| | - Yamin Li
- Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
| |
Collapse
|
38
|
Bauer M, Glenn T, Geddes J, Gitlin M, Grof P, Kessing LV, Monteith S, Faurholt-Jepsen M, Severus E, Whybrow PC. Smartphones in mental health: a critical review of background issues, current status and future concerns. Int J Bipolar Disord 2020; 8:2. [PMID: 31919635 PMCID: PMC6952480 DOI: 10.1186/s40345-019-0164-x] [Citation(s) in RCA: 61] [Impact Index Per Article: 12.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/26/2019] [Accepted: 10/24/2019] [Indexed: 02/06/2023] Open
Abstract
There has been increasing interest in the use of smartphone applications (apps) and other consumer technology in mental health care for a number of years. However, the vision of data from apps seamlessly returned to, and integrated in, the electronic medical record (EMR) to assist both psychiatrists and patients has not been widely achieved, due in part to complex issues involved in the use of smartphone and other consumer technology in psychiatry. These issues include consumer technology usage, clinical utility, commercialization, and evolving consumer technology. Technological, legal and commercial issues, as well as medical issues, will determine the role of consumer technology in psychiatry. Recommendations for a more productive direction for the use of consumer technology in psychiatry are provided.
Collapse
Affiliation(s)
- Michael Bauer
- Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
| | - Tasha Glenn
- ChronoRecord Association, Fullerton, CA, USA
| | - John Geddes
- Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
| | - Michael Gitlin
- Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles (UCLA), Los Angeles, CA, USA
| | - Paul Grof
- Mood Disorders Center of Ottawa, Ottawa, Canada
- Department of Psychiatry, University of Toronto, Toronto, ON, Canada
| | - Lars V Kessing
- Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Center Copenhagen, Rigshospitalet, Copenhagen, Denmark
| | - Scott Monteith
- Michigan State University College of Human Medicine, Traverse City Campus, Traverse City, MI, USA
| | - Maria Faurholt-Jepsen
- Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Center Copenhagen, Rigshospitalet, Copenhagen, Denmark
| | - Emanuel Severus
- Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany
| | - Peter C Whybrow
- Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles (UCLA), Los Angeles, CA, USA
| |
Collapse
|
39
|
De Nobrega AK, Luz KV, Lyons LC. Resetting the Aging Clock: Implications for Managing Age-Related Diseases. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY 2020; 1260:193-265. [PMID: 32304036 DOI: 10.1007/978-3-030-42667-5_9] [Citation(s) in RCA: 11] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/14/2022]
Abstract
Worldwide, individuals are living longer due to medical and scientific advances, increased availability of medical care and changes in public health policies. Consequently, increasing attention has been focused on managing chronic conditions and age-related diseases to ensure healthy aging. The endogenous circadian system regulates molecular, physiological and behavioral rhythms orchestrating functional coordination and processes across tissues and organs. Circadian disruption or desynchronization of circadian oscillators increases disease risk and appears to accelerate aging. Reciprocally, aging weakens circadian function aggravating age-related diseases and pathologies. In this review, we summarize the molecular composition and structural organization of the circadian system in mammals and humans, and evaluate the technological and societal factors contributing to the increasing incidence of circadian disorders. Furthermore, we discuss the adverse effects of circadian dysfunction on aging and longevity and the bidirectional interactions through which aging affects circadian function using examples from mammalian research models and humans. Additionally, we review promising methods for managing healthy aging through behavioral and pharmacological reinforcement of the circadian system. Understanding age-related changes in the circadian clock and minimizing circadian dysfunction may be crucial components to promote healthy aging.
Collapse
Affiliation(s)
- Aliza K De Nobrega
- Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL, USA
| | - Kristine V Luz
- Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL, USA
| | - Lisa C Lyons
- Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL, USA.
| |
Collapse
|
40
|
De Nobrega AK, Lyons LC. Aging and the clock: Perspective from flies to humans. Eur J Neurosci 2020; 51:454-481. [PMID: 30269400 PMCID: PMC6441388 DOI: 10.1111/ejn.14176] [Citation(s) in RCA: 27] [Impact Index Per Article: 5.4] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/07/2018] [Revised: 09/10/2018] [Accepted: 09/17/2018] [Indexed: 12/15/2022]
Abstract
Endogenous circadian oscillators regulate molecular, cellular and physiological rhythms, synchronizing tissues and organ function to coordinate activity and metabolism with environmental cycles. The technological nature of modern society with round-the-clock work schedules and heavy reliance on personal electronics has precipitated a striking increase in the incidence of circadian and sleep disorders. Circadian dysfunction contributes to an increased risk for many diseases and appears to have adverse effects on aging and longevity in animal models. From invertebrate organisms to humans, the function and synchronization of the circadian system weakens with age aggravating the age-related disorders and pathologies. In this review, we highlight the impacts of circadian dysfunction on aging and longevity and the reciprocal effects of aging on circadian function with examples from Drosophila to humans underscoring the highly conserved nature of these interactions. Additionally, we review the potential for using reinforcement of the circadian system to promote healthy aging and mitigate age-related pathologies. Advancements in medicine and public health have significantly increased human life span in the past century. With the demographics of countries worldwide shifting to an older population, there is a critical need to understand the factors that shape healthy aging. Drosophila melanogaster, as a model for aging and circadian interactions, has the capacity to facilitate the rapid advancement of research in this area and provide mechanistic insights for targeted investigations in mammals.
Collapse
Affiliation(s)
- Aliza K De Nobrega
- Program in Neuroscience, Department of Biological Science, Florida State University, Tallahassee, Florida
| | - Lisa C Lyons
- Program in Neuroscience, Department of Biological Science, Florida State University, Tallahassee, Florida
| |
Collapse
|
41
|
Lin CW, Yang CM, Yang CH. Effects of the Emitted Light Spectrum of Liquid Crystal Displays on Light-Induced Retinal Photoreceptor Cell Damage. Int J Mol Sci 2019; 20:ijms20092318. [PMID: 31083373 PMCID: PMC6539598 DOI: 10.3390/ijms20092318] [Citation(s) in RCA: 8] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/08/2019] [Revised: 04/30/2019] [Accepted: 05/08/2019] [Indexed: 02/05/2023] Open
Abstract
Liquid crystal displays (LCDs) are used as screens in consumer electronics and are indispensable in the modern era of computing. LCDs utilize light-emitting diodes (LEDs) as backlight modules and emit high levels of blue light, which may cause retinal photoreceptor cell damage. However, traditional blue light filters may decrease the luminance of light and reduce visual quality. We adjusted the emitted light spectrum of LED backlight modules in LCDs and reduced the energy emission but maintained the luminance. The 661W photoreceptor cell line was used as the model system. We established a formula of the ocular energy exposure index (OEEI), which could be used as the indicator of LCD energy emission. Cell viability decreased and apoptosis increased significantly after exposure to LCDs with higher emitted energy. Cell damage occurred through the induction of oxidative stress and mitochondrial dysfunction. The molecular mechanisms included activation of the NF-κB pathway and upregulation of the expression of proteins associated with inflammation and apoptosis. The effect was correlated with OEEI intensity. We demonstrated that LCD exposure-induced photoreceptor damage was correlated with LCD energy emission. LCDs with lower energy emission may, therefore, serve as suitable screens to prevent light-induced retinal damage and protect consumers’ eye health.
Collapse
Affiliation(s)
- Chao-Wen Lin
- Departments of Ophthalmology, National Taiwan University Hospital, No.7, Zhongshan South Road, Taipei 100, Taiwan.
| | - Chung-May Yang
- Departments of Ophthalmology, National Taiwan University Hospital, No.7, Zhongshan South Road, Taipei 100, Taiwan.
| | - Chang-Hao Yang
- Departments of Ophthalmology, National Taiwan University Hospital, No.7, Zhongshan South Road, Taipei 100, Taiwan.
| |
Collapse
|
42
|
Ahmed SF, McDermott KC, Burge WK, Ahmed IIK, Varma DK, Liao YJ, Crandall AS, Khaderi SKR. Visual function, digital behavior and the vision performance index. Clin Ophthalmol 2018; 12:2553-2561. [PMID: 30573945 PMCID: PMC6292403 DOI: 10.2147/opth.s187131] [Citation(s) in RCA: 11] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/30/2022] Open
Abstract
Historically, visual acuity has been the benchmark for visual function. It is used to measure therapeutic outcomes for vision-related services, products and interventions. Quantitative measurement of suboptimal visual acuity can potentially be corrected optically with proper refraction in some cases, but in many cases of reduced vision there is something else more serious that can potentially impact other aspects of visual function such as contrast sensitivity, color discrimination, peripheral field of view and higher-order visual processing. The measurement of visual acuity typically requires stimuli subject to some degree of standardization or calibration and has thus often been limited to clinical settings. However, we are spending increasing amounts of time interacting with devices that present high-resolution, full color images and video (hereafter, digital media) and can record our responses. Most of these devices can be used to measure visual acuity and other aspects of visual function, not just with targeted testing experiences but from typical device interactions. There is growing evidence that prolonged exposure to digital media can lead to various vision-related issues (eg, computer vision syndrome, dry eye, etc.). Our regular, daily interactions (digital behavior) can also be used to assess our visual function, passively and continuously. This allows us to expand vision health assessment beyond the clinic, to collect vision-related data in the whole range of settings for typical digital behavior from practically any population(s) of interest and to further explore just how our increasingly virtual interactions are affecting our vision. We present a tool that can be easily integrated into digital media to provide insights into our digital behavior.
Collapse
Affiliation(s)
- Sarah Farukhi Ahmed
- Shiley Eye Institute of Ophthalmology, University of California, San Diego, CA, USA
| | | | | | - I Ike K Ahmed
- Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.,Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA
| | - Devesh K Varma
- Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada
| | - Y Joyce Liao
- Ophthalmology and Neurology, Stanford University Medical Center, Stanford, CA, USA
| | - Alan S Crandall
- Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA
| | - S Khizer R Khaderi
- Vizzario, Inc., Venice, CA, USA, .,Ophthalmology, Stanford University Medical Center, Stanford, CA, USA,
| |
Collapse
|
43
|
Mortazavi SAR, Parhoodeh S, Hosseini MA, Arabi H, Malakooti H, Nematollahi S, Mortazavi G, Darvish L, Mortazavi SMJ. Blocking Short-Wavelength Component of the Visible Light Emitted by Smartphones' Screens Improves Human Sleep Quality. J Biomed Phys Eng 2018; 8:375-380. [PMID: 30568927 PMCID: PMC6280115] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/11/2016] [Accepted: 11/08/2016] [Indexed: 10/25/2022]
Abstract
BACKGROUND It has been shown that short-wavelength blue component of the visible light spectrum can alter the circadian rhythm and suppress the level of melatonin hormone. The short-wavelength light emitted by smartphones' screens can affect the sleep quality of the people who use these devices at night through suppression of melatonin. OBJECTIVES In this study, we examined the effects of covering the screens of smartphones with different filters (changing the effective wavelength of the light) on sleep delay time in 43 healthy students. MATERIALS AND METHODS Volunteer students were asked to go to bed at 23:00 and to use their mobile phones in bed for watching a natural life documentary movie for 60 minutes. No filter was used for one night while amber and blue filters were used for other 2 nights. Photospectrometry method was used to determine the output spectrum of the light passing through the filters used for covering the screens of the mobile phones. The order for utilizing amber or blue filters or using no filter was selected randomly. After 1 hour, the participants were asked to record their sleep delay time measured by a modified form of sleep time record sheet. RESULTS The mean sleep delay time for the "no-filter" night was 20.84±9.15 minutes, while the sleep delay times for the nights with amber and blue filters were 15.26±1.04 and 26.33±1.59 minutes, respectively. CONCLUSION The findings obtained in this study support this hypothesis that blue light possibly suppresses the secretion of melatonin more than the longer wavelengths of the visible light spectrum. Using amber filter in this study significantly improved the sleep quality. Altogether, these findings lead us to this conclusion that blocking the short-wavelength component of the light emitted by smartphones' screens improves human sleep.
Collapse
Affiliation(s)
- S A R Mortazavi
- Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| | - S Parhoodeh
- Physics Department, Shiraz branch, Islamic Azad University, Shiraz, Iran
| | - M A Hosseini
- Ionizing and Non-Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran
| | - H Arabi
- Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| | - H Malakooti
- Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| | - S Nematollahi
- Biostatistics Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| | - G Mortazavi
- Ionizing and Non-Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran
| | - L Darvish
- Department of Radiology, Faculty of Para-Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
| | - S M J Mortazavi
- Ionizing and Non-Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran
- Medical Physics and Medical Engineering Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| |
Collapse
|
44
|
Mortazavi SMJ. Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study'. Br J Cancer 2018; 118:1536. [PMID: 29769746 PMCID: PMC5988714 DOI: 10.1038/s41416-018-0060-7] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/31/2018] [Revised: 02/09/2018] [Accepted: 02/22/2018] [Indexed: 12/12/2022] Open
Affiliation(s)
- S M J Mortazavi
- Department of Diagnostic Imaging, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA, 19111, USA. .,Ionizing and Non-ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran.
| |
Collapse
|
45
|
Bauer M, Glenn T, Monteith S, Gottlieb JF, Ritter PS, Geddes J, Whybrow PC. The potential influence of LED lighting on mental illness. World J Biol Psychiatry 2018; 19:59-73. [PMID: 29251065 DOI: 10.1080/15622975.2017.1417639] [Citation(s) in RCA: 29] [Impact Index Per Article: 4.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 10/18/2022]
Abstract
OBJECTIVES Two recent scientific breakthroughs may alter the treatment of mental illness, as discussed in this narrative review. The first was the invention of white light-emitting diodes (LEDs), which enabled an ongoing, rapid transition to energy-efficient LEDs for lighting, and the use of LEDs to backlight digital devices. The second was the discovery of melanopsin-expressing photosensitive retinal ganglion cells, which detect environmental irradiance and mediate non-image forming (NIF) functions including circadian entrainment, melatonin secretion, alertness, sleep regulation and the pupillary light reflex. These two breakthroughs are interrelated because unlike conventional lighting, white LEDs have a dominant spectral wavelength in the blue light range, near the peak sensitivity for the melanopsin system. METHODS Pertinent articles were identified. RESULTS Blue light exposure may suppress melatonin, increase alertness, and interfere with sleep in young, healthy volunteers and in animals. Areas of concern in mental illness include the influence of blue light on sleep, other circadian-mediated symptoms, prescribed treatments that target the circadian system, measurement using digital apps and devices, and adolescent sensitivity to blue light. CONCLUSIONS While knowledge in both fields is expanding rapidly, future developments must address the potential impact of blue light on NIF functions for healthy individuals and those with mental illness.
Collapse
Affiliation(s)
- Michael Bauer
- a Department of Psychiatry and Psychotherapy , University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden , Dresden , Germany
| | - Tasha Glenn
- b ChronoRecord Association, Inc , Fullerton , CA , USA
| | - Scott Monteith
- c Michigan State University College of Human Medicine, Traverse City Campus , Traverse City , MI , USA
| | - John F Gottlieb
- d Department of Psychiatry , Feinberg School of Medicine, Northwestern University , Chicago , IL , USA
| | - Philipp S Ritter
- a Department of Psychiatry and Psychotherapy , University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden , Dresden , Germany
| | - John Geddes
- e Department of Psychiatry , University of Oxford, Warneford Hospital , Oxford , UK
| | - Peter C Whybrow
- f Department of Psychiatry and Biobehavioral Sciences , Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles (UCLA) , Los Angeles , CA , USA
| |
Collapse
|
46
|
De Nobrega AK, Lyons LC. Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse. Neural Plast 2017; 2017:4723836. [PMID: 29391952 PMCID: PMC5748135 DOI: 10.1155/2017/4723836] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/16/2017] [Accepted: 08/13/2017] [Indexed: 01/12/2023] Open
Abstract
Endogenous circadian oscillators orchestrate rhythms at the cellular, physiological, and behavioral levels across species to coordinate activity, for example, sleep/wake cycles, metabolism, and learning and memory, with predictable environmental cycles. The 21st century has seen a dramatic rise in the incidence of circadian and sleep disorders with globalization, technological advances, and the use of personal electronics. The circadian clock modulates alcohol- and drug-induced behaviors with circadian misalignment contributing to increased substance use and abuse. Invertebrate models, such as Drosophila melanogaster, have proven invaluable for the identification of genetic and molecular mechanisms underlying highly conserved processes including the circadian clock, drug tolerance, and reward systems. In this review, we highlight the contributions of Drosophila as a model system for understanding the bidirectional interactions between the circadian system and the drugs of abuse, alcohol and cocaine, and illustrate the highly conserved nature of these interactions between Drosophila and mammalian systems. Research in Drosophila provides mechanistic insights into the corresponding behaviors in higher organisms and can be used as a guide for targeted inquiries in mammals.
Collapse
Affiliation(s)
- Aliza K. De Nobrega
- Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA
| | - Lisa C. Lyons
- Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA
| |
Collapse
|
47
|
Mortazavi SMJ. RE: "MODELED AND PERCEIVED EXPOSURE TO RADIOFREQUENCY ELECTROMAGNETIC FIELDS FROM MOBILE-PHONE BASE STATIONS AND THE DEVELOPMENT OF SYMPTOMS OVER TIME IN A GENERAL POPULATION COHORT". Am J Epidemiol 2017; 186:1217. [PMID: 29036398 DOI: 10.1093/aje/kwx315] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/19/2017] [Accepted: 07/24/2017] [Indexed: 11/12/2022] Open
Affiliation(s)
- S M J Mortazavi
- Department of Diagnostic Imaging, Fox Chase Cancer Center, Philadelphia, PA
| |
Collapse
|
48
|
Mortazavi SMJ. Comment on “Technology as a Tool to Encourage Young Adults to Sleep and Eat Healthy”. ACSM'S HEALTH & FITNESS JOURNAL 2017. [DOI: 10.1249/fit.0000000000000339] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/21/2022]
|
49
|
Kim DJ, Lim CY, Gu N, Park CY. Visual Fatigue Induced by Viewing a Tablet Computer with a High-resolution Display. KOREAN JOURNAL OF OPHTHALMOLOGY 2017; 31:388-393. [PMID: 28914003 PMCID: PMC5636714 DOI: 10.3341/kjo.2016.0095] [Citation(s) in RCA: 53] [Impact Index Per Article: 6.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/29/2016] [Accepted: 12/12/2016] [Indexed: 11/23/2022] Open
Abstract
Purpose In the present study, the visual discomfort induced by smart mobile devices was assessed in normal and healthy adults. Methods Fifty-nine volunteers (age, 38.16 ± 10.23 years; male : female = 19 : 40) were exposed to tablet computer screen stimuli (iPad Air, Apple Inc.) for 1 hour. Participants watched a movie or played a computer game on the tablet computer. Visual fatigue and discomfort were assessed using an asthenopia questionnaire, tear film break-up time, and total ocular wavefront aberration before and after viewing smart mobile devices. Results Based on the questionnaire, viewing smart mobile devices for 1 hour significantly increased mean total asthenopia score from 19.59 ± 8.58 to 22.68 ± 9.39 (p < 0.001). Specifically, the scores for five items (tired eyes, sore/aching eyes, irritated eyes, watery eyes, and hot/burning eye) were significantly increased by viewing smart mobile devices. Tear film break-up time significantly decreased from 5.09 ± 1.52 seconds to 4.63 ± 1.34 seconds (p = 0.003). However, total ocular wavefront aberration was unchanged. Conclusions Visual fatigue and discomfort were significantly induced by viewing smart mobile devices, even though the devices were equipped with state-of-the-art display technology.
Collapse
Affiliation(s)
- Dong Ju Kim
- Department of Ophthalmology, Dongguk University Ilsan Hospital, Goyang, Korea
| | - Chi Yeon Lim
- Department of Biostatistics, Dongguk University Ilsan Hospital, Goyang, Korea
| | - Namyi Gu
- Department of Clinical Pharmacology and Therapeutics, Dongguk University Ilsan Hospital, Goyang, Korea
| | - Choul Yong Park
- Department of Ophthalmology, Dongguk University Ilsan Hospital, Goyang, Korea.
| |
Collapse
|
50
|
Circadian-tunable Perovskite Quantum Dot-based Down-Converted Multi-Package White LED with a Color Fidelity Index over 90. Sci Rep 2017; 7:2808. [PMID: 28584229 PMCID: PMC5459832 DOI: 10.1038/s41598-017-03063-7] [Citation(s) in RCA: 39] [Impact Index Per Article: 4.9] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/24/2017] [Accepted: 04/21/2017] [Indexed: 11/25/2022] Open
Abstract
New metrics of the color and circadian performances of down-converted white light-emitting diodes (DC-WLEDs) are rapidly becoming popular in smart lighting systems. This is due to the increased desire for accurate analytical methods to measure the effects of newly developed quantum dot (QD)-based lighting on the vision, color, and circadian sensors of retina cells in the human eye. In this regard, a two-measure system known as technical memorandum TM-30-2015 (Illuminating Engineering Society of North America), encompassing the color fidelity index (CFI, Rf) and the color gamut index (CGI, Rg), has been developed as a new metrics of color to replace the currently utilized color rendering index (CRI, Ra). In addition, the tunability of the circadian efficacy of radiation (CER) is now more important due to its effect on the control of melatonin suppression/secretion, resetting of the central/local clocks of individuals given their daily cycles, and benefits to human health. In this paper, we developed and analyzed six-colored perovskite (Pe; cyan, green, yellowish green, amber, orange, and red colors) QDs-based multi-package WLED, and optimized the SPDs of tunable PeQD-based multi-package WLEDs in terms of promising human-centric lighting device, given its optimized visual energy, color qualities and health-promoting effects.
Collapse
|