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Wang AG, Zhang JN, Hu LX, Liu YS, Ying GG, Liang YX, Xu MY, Yu ZQ. Fate and transformation of psychotropic drugs in urban wastewater systems and receiving rivers via the integration of targeted and suspect screening analysis. WATER RESEARCH 2025; 276:123292. [PMID: 39955790 DOI: 10.1016/j.watres.2025.123292] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 08/19/2024] [Revised: 02/06/2025] [Accepted: 02/12/2025] [Indexed: 02/18/2025]
Abstract
Psychotropic drugs rank among the most prescribed pharmaceuticals in the world. The ubiquitous occurrence of psychotropic drugs in the environment evoked rising concerns due to their various toxic effect on non-target organisms at low concentrations. However, the removal, transformation, and discharging of these drugs throughout wastewater treatment plants (WWTPs) have rarely been reported. Based on the targeted analysis and suspected screening, this study investigated the distribution of psychotropic drugs and their transformation products (TPs) within the entire treatment processes in WWTPs and their receiving rivers. The results indicated that 13 out of 47 psychotropic drugs are widely observed across wastewater, sludge, receiving river water, and sediment, respectively. The aqueous removal efficiencies of most psychotropic drugs exhibited their significant recalcitrance in wastewater treatment processes. For instance, venlafaxine (VEL) was slightly removed by 2.64 % and 10.8 % in these two WWTPs. The concentrations of oxazepam (OZP) and lamotrigine (LMT) dramatically increased after the overall treatment processes due to their metabolic conversion and regeneration processes, respectively. Given the recalcitrance of psychotropic drugs, the identified TPs generated within WWTPs were not abundant, but a wider variety of TPs were identified from human metabolites. A total of 25 TPs were identified via the suspect screening analysis, of which nine were newly identified. In receiving rivers, the risk quotient (RQ) presented OZP, sertraline (SER), and VEL posed high potential risks; the integration of the toxicological priority index (ToxPi) and the toxicity-weighted concentration (TWC) suggested TP-CIT-322 and TP-OCX-195 as the high-priority contaminants. Given the recalcitrance and environmental risks of psychotropic drugs and their TPs in WWTPs and environments, it is crucial for the further exploration of their effective treatment technologies and emission control strategies .
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Affiliation(s)
- An-Guo Wang
- State Key Laboratory of Advanced Environmental Technology, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, PR China; Guangdong Environmental Protection Key Laboratory of Microbiology and Ecological Safety, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China
| | - Jin-Na Zhang
- Guangdong Environmental Protection Key Laboratory of Microbiology and Ecological Safety, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070, PR China; SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Environmental Theoretical Chemistry, South China Normal University, Guangzhou, 510006, PR China
| | - Li-Xin Hu
- SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Environmental Theoretical Chemistry, South China Normal University, Guangzhou, 510006, PR China
| | - You-Sheng Liu
- SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Environmental Theoretical Chemistry, South China Normal University, Guangzhou, 510006, PR China
| | - Guang-Guo Ying
- SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Environmental Theoretical Chemistry, South China Normal University, Guangzhou, 510006, PR China
| | - Yin-Xiu Liang
- Guangdong Environmental Protection Key Laboratory of Microbiology and Ecological Safety, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070, PR China
| | - Mei-Ying Xu
- Guangdong Environmental Protection Key Laboratory of Microbiology and Ecological Safety, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070, PR China.
| | - Zhi-Qiang Yu
- State Key Laboratory of Advanced Environmental Technology, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, PR China.
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Tee NCH, Yeo JA, Choolani M, Poh KK, Ang TL. Healthcare in the era of climate change and the need for environmental sustainability. Singapore Med J 2024; 65:204-210. [PMID: 38650058 PMCID: PMC11132617 DOI: 10.4103/singaporemedj.smj-2024-035] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/01/2024] [Accepted: 02/05/2024] [Indexed: 04/25/2024]
Abstract
ABSTRACT Climate change is an existential threat to humanity. While the healthcare sector must manage the health-related consequences of climate change, it is a significant contributor to greenhouse gas emissions, responsible for up to 4.6% of global emission, aggravating global warming. Within the hospital environment, the three largest contributors to greenhouse gas emissions are the operating theatre, intensive care unit and gastrointestinal endoscopy. Knowledge of the health-related burden of climate change and the potential transformative health benefits of climate action is important to all health professionals, as they play crucial roles in effecting change. This article summarises the available literature on the impact of healthcare on climate change and efforts in mitigation, focusing on the intrinsic differences and similarities across the operating theatre complex, intensive care unit and gastrointestinal endoscopy unit. It also discusses strategies to reduce carbon footprint.
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Affiliation(s)
- Nicholas Chin Hock Tee
- Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore
- Duke-NUS Medical School, Singapore
- Yong Loo Lin School of Medicine, National University of Singapore, Singapore
- Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
| | - Jo-Anne Yeo
- Duke-NUS Medical School, Singapore
- Department of Anaesthesia and Surgical Intensive Care, Changi General Hospital, Singapore
| | - Mahesh Choolani
- Yong Loo Lin School of Medicine, National University of Singapore, Singapore
- Department of Obstetrics and Gynaecology, National University Hospital, Singapore
| | - Kian Keong Poh
- Yong Loo Lin School of Medicine, National University of Singapore, Singapore
- Department of Cardiology, National University Hospital, Singapore
| | - Tiing Leong Ang
- Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore
- Duke-NUS Medical School, Singapore
- Yong Loo Lin School of Medicine, National University of Singapore, Singapore
- Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
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Wang A, Zhang J, Hu L, Yu Z, Lai S, Liu Y, Mai Z, Xu M. Trace analysis of 47 psychotropic medications in environmental samples by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). J Chromatogr A 2024; 1715:464627. [PMID: 38171065 DOI: 10.1016/j.chroma.2023.464627] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/10/2023] [Revised: 12/19/2023] [Accepted: 12/30/2023] [Indexed: 01/05/2024]
Abstract
Psychotropic medications are one of the most prescribed pharmaceuticals in the world. Given their frequent detection and ecotoxicity to the no-target organism, the emission of these medications into environments has gradually draw attention. The study developed a sensitive and reliable analytic method to simultaneously investigate 47 psychotropic medications in four matrices: wastewater, surface water, activated sludge, and sediment by ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS). These 47 target analytes include 24 antidepressants, 17 antianxiety drugs, 5 anticonvulsants, and 1 relevant hormone. Solid phase extraction (SPE) was employed to extract analytes from water-phase samples. Ultrasonic Solvent Extraction method with Enhanced Matrix Removal clean-up (USE-EMR) was utilized to extract target compounds from solid-phase samples, which requires more straightforward and convenient procedures than previous methods. The extraction recoveries of all analytes ranged from 80 % to 120 % in these four sample matrices. In this study, The limit of quantitation for 47 psychotropic medications were 0.15 ng/L (estazolam) to 2.27 ng/L (lorazepam), 0.08 ng/L (desvenlafaxine) to 2 ng/L (mianserin), 0.22 ng/g (dry weight, dw) (nordiazepam) to 3.65 ng/g (dw) (lorazepam), and 0.07 ng/g (dw) (carbamazepine) to 2.85 ng/g (lorazepam), in wastewater, surface water, sludge, and sediment, respectively. In addition, the developed method was employed to analyse actual samples in two wastewater treatment plants and their receiving rivers. Carbamazepine, escitalopram, clozapine, desvenlafaxine, diazepam, lamotrigine, sertraline, temazepam, and venlafaxine were nearly ubiquitous in all matrices. Moreover, this study indicated that the inadequate removal efficiencies of psychotropic medications in wastewater treatment plants (WWTPs) had resulted in a persistent discharge of these contaminants from human sources into environments.
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Affiliation(s)
- Anguo Wang
- State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, PR China; Guangdong Environmental Protection Key Laboratory of Microbiology and Ecological Safety, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China
| | - Jinna Zhang
- Guangdong Environmental Protection Key Laboratory of Microbiology and Ecological Safety, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, PR China
| | - Lixin Hu
- SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Environmental Theoretical Chemistry, South China Normal University, Guangzhou 510006, PR China
| | - Zhiqiang Yu
- State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, PR China
| | - Sihua Lai
- Guangdong Environmental Protection Key Laboratory of Microbiology and Ecological Safety, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, PR China
| | - Yousheng Liu
- SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Environmental Theoretical Chemistry, South China Normal University, Guangzhou 510006, PR China
| | - Zhiyuan Mai
- Guangdong Environmental Protection Key Laboratory of Microbiology and Ecological Safety, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, PR China
| | - Meiying Xu
- Guangdong Environmental Protection Key Laboratory of Microbiology and Ecological Safety, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, PR China.
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Su M, Zhong Y, Xiang J, Chen Y, Liu N, Zhang J. Reproductive endocrine disruption and gonadal intersex induction in male Japanese medaka chronically exposed to betamethasone at environmentally relevant levels. JOURNAL OF HAZARDOUS MATERIALS 2023; 455:131493. [PMID: 37156043 DOI: 10.1016/j.jhazmat.2023.131493] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 01/08/2023] [Revised: 04/06/2023] [Accepted: 04/23/2023] [Indexed: 05/10/2023]
Abstract
The broad utilization of betamethasone in medical treatments may pose a significant ecotoxicological risk to aquatic organisms, yet its potential reproductive toxicity remains unclear. The present study examined the impacts of environmental exposure on male reproduction using Japanese medaka (Oryzias latipes). After 110 days of betamethasone exposure at environmentally relevant concentrations (0, 20 and 200 ng/L), LH/FSH synthesis and release in the pituitary was inhibited, and the production of sex hormones and their signaling pathways in the gonads of male medaka were greatly influenced. This synthetic glucocorticoid restrained testosterone (T) synthesis and gave rise to a significant increase in E2/T and E2/11-KT ratios. Furthermore, chronic betamethasone exposure (20 and 200 ng/L) led to the suppression of androgen receptor (AR) signaling and enhancement of estrogen receptors (ERs) signaling. An increase in hepatic vitellogenin contents was also detected, and testicular oocytes were observed in both 20 and 200 ng/L betamethasone-treated groups. It showed that 20 and 200 ng/L betamethasone could induce male feminization and even intersex, triggering abnormal spermatogenesis in medaka males. With its adverse effects on male fertility, betamethasone could potentially influence the fishery productivity and population dynamics in aquatic ecosystems.
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Affiliation(s)
- Maoliang Su
- Shenzhen Key Laboratory of Marine Bioresource & Eco-Environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China
| | - Youling Zhong
- Shenzhen Key Laboratory of Marine Bioresource & Eco-Environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China
| | - Jiazhi Xiang
- Shenzhen Key Laboratory of Marine Bioresource & Eco-Environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China
| | - Yuru Chen
- College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China
| | - Nanxi Liu
- Shenzhen Key Laboratory of Marine Bioresource & Eco-Environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China
| | - Junbin Zhang
- Shenzhen Key Laboratory of Marine Bioresource & Eco-Environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
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Mandal S, Islam M, Ghosh P, Mandal S, Sahoo P. Reliable Detection of Fluoroquinolones in Pharma‐effluents: Increasing Exposure in Environment Triggers Rise of Antimicrobial Resistance. ChemistrySelect 2023. [DOI: 10.1002/slct.202203353] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/15/2023]
Affiliation(s)
- Saurodeep Mandal
- Department of Chemistry Visva Bharati Santiniketan 731235 Birbhum, West Bengal India
| | - Majharul Islam
- Department of Microbiology University of Calcutta Kolkata 700019 West Bengal India
| | - Priyotosh Ghosh
- Department of Chemistry Visva Bharati Santiniketan 731235 Birbhum, West Bengal India
| | - Sukhendu Mandal
- Department of Microbiology University of Calcutta Kolkata 700019 West Bengal India
| | - Prithidipa Sahoo
- Department of Chemistry Visva Bharati Santiniketan 731235 Birbhum, West Bengal India
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Gao X, Huang K, Zhang A, Wang C, Sun Z, Liu Y. Simultaneous degradation of glucocorticoids and sterilization using bubbling corona discharge plasma based systems: A promising terminal water treatment facility for hospital wastewater. CHEMICAL ENGINEERING JOURNAL (LAUSANNE, SWITZERLAND : 1996) 2022; 430:132845. [PMID: 36569380 PMCID: PMC9764632 DOI: 10.1016/j.cej.2021.132845] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 06/17/2021] [Revised: 09/29/2021] [Accepted: 10/01/2021] [Indexed: 05/30/2023]
Abstract
Glucocorticoids (GCs) have drawn great concern due to their widespread contamination in the environment and application in treating patients with COVID-19. Due to the lack of data about GC removal using advanced treatment processes, a novel Paralleling and bubbling corona discharge reactor (PBCD) combined with iron-loaded activated-carbon fibre (Fe-ACF) was addressed in this study to degrade GCs represented by Hydrocortisone (HC) and Betamethasone (BT). The results showed that the PBCD-based system can degrade GCs effectively and can achieve effective sterilization. The removal rates of GCs were ranked as PBCD/Fe-ACF > PBCD/ACF > PBCD. The concentration of E. coli was reduced from 109 to 102 CFU/mL after 60 min of PBCD-based system treatment. The abundance of bacteria in actual Hospital wastewater (HWW) was significantly reduced. Plasma changed the physical and chemical properties of ACF and Fe-ACF by etching axial grooves and enhancing stretching vibrations of surface functional groups, thus promoting adsorption and catalytic degradation. For GC degradation, the functional reactive species were identified as •OH, 1O2, and •O2 radicals. Possible degradation pathways for HC and BT were proposed, which mainly included defluorination, keto acid decarboxylation, demethylation, intramolecular cyclization, cleavage and ester hydrolysis, indicating a reduction in GC toxicity. Since GCs are widely used in patients with COVID-19 and their wastewater needs to be sterilized simultaneously, the intensive and electrically driven PBCD-based system is promising in GC pollution control and sterilization in terminal water treatment facilities.
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Affiliation(s)
- Xiaoting Gao
- College of Environmental Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, China
| | - Keliang Huang
- College of Environmental Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, China
| | - Ai Zhang
- College of Environmental Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, China
| | - Cihao Wang
- College of Environmental Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, China
| | - Zhuyu Sun
- College of Environmental Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, China
| | - Yanan Liu
- College of Environmental Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, China
- Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China
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Argaluza J, Domingo-Echaburu S, Orive G, Medrano J, Hernandez R, Lertxundi U. Environmental pollution with psychiatric drugs. World J Psychiatry 2021; 11:791-804. [PMID: 34733642 PMCID: PMC8546762 DOI: 10.5498/wjp.v11.i10.791] [Citation(s) in RCA: 13] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/23/2021] [Revised: 06/25/2021] [Accepted: 08/31/2021] [Indexed: 02/06/2023] Open
Abstract
Among all contaminants of emerging interest, drugs are the ones that give rise to the greatest concern. Any of the multiple stages of the drug's life cycle (production, consumption and waste management) is a possible entry point to the different environmental matrices. Psychiatric drugs have received special attention because of two reasons. First, their use is increasing. Second, many of them act on phylogenetically highly conserved neuroendocrine systems, so they have the potential to affect many non-target organisms. Currently, wastewater is considered the most important source of drugs to the environment. Furthermore, the currently available wastewater treatment plants are not specifically prepared to remove drugs, so they reach practically all environmental matrices, even tap water. As drugs are designed to produce pharmacological effects at low concentrations, they are capable of producing ecotoxicological effects on microorganisms, flora and fauna, even on human health. It has also been observed that certain antidepressants and antipsychotics can bioaccumulate along the food chain. Drug pollution is a complicated and diffuse problem characterized by scientific uncertainties, a large number of stakeholders with different values and interests, and enormous complexity. Possible solutions consist on acting at source, using medicines more rationally, eco-prescribing or prescribing greener drugs, designing pharmaceuticals that are more readily biodegraded, educating both health professionals and citizens, and improving coordination and collaboration between environmental and healthcare sciences. Besides, end of pipe measures like improving or developing new purification systems (biological, physical, chemical, combination) that eliminate these residues efficiently and at a sustainable cost should be a priority. Here, we describe and discuss the main aspects of drug pollution, highlighting the specific issues of psychiatric drugs.
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Affiliation(s)
- Julene Argaluza
- Department of Epidemiology and Public Health, Bioaraba Health Research Institute, Vitoria-Gasteiz 01002, Spain
| | - Saioa Domingo-Echaburu
- Department of Pharmacy, Alto Deba Integrated Health Care Organization, Arrasate 20500, Spain
| | - Gorka Orive
- NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU, Paseo de la Universidad 7, Vitoria-Gasteiz 01006, Spain
- Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz 01006, Spain
- Bioaraba, NanoBioCel Research Group, Vitoria-Gasteiz 01006, Spain
- Singapore Eye Research Institute, Discovery Tower, Singapore 168751, Singapore
| | - Juan Medrano
- Department of Psychiatry, Biocruces Bizkaia Health Research Institute, Mental Health Network Research Group, Osakidetza, Portugalete 48920, Spain
| | - Rafael Hernandez
- Department of Internal Medicine, Araba Mental Health Network, Vitoria-Gasteiz 01006, Spain
| | - Unax Lertxundi
- Bioaraba Health Research Institute; Osakidetza Basque Health Service, Araba Mental Health Network, Araba Psychiatric Hospital, Pharmacy Service, Vitoria-Gasteiz 01006, Alava, Spain
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Zhang A, He J, Shen Y, Xu X, Liu Y, Li Y, Wu S, Xue G, Li X, Makinia J. Enhanced degradation of glucocorticoids, a potential COVID-19 remedy, by co-fermentation of waste activated sludge and animal manure: The role of manure type and degradation mechanism. ENVIRONMENTAL RESEARCH 2021; 201:111488. [PMID: 34153334 DOI: 10.1016/j.envres.2021.111488] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 04/30/2021] [Revised: 05/31/2021] [Accepted: 06/03/2021] [Indexed: 06/13/2023]
Abstract
Waste activated sludge (WAS) and animal manure are two significant reservoirs of glucocorticoids (GCs) in the environment. However, GC degradation during anaerobic digestion (AD) of WAS or animal manure has rarely been investigated. In this study, co-fermentation of WAS and animal manure was conducted to investigate the performance of AD in controlling GC dissemination. Effects of manure type on GC degradation and sludge acidification were investigated. The results showed that co-fermentation of WAS and chicken manure (CM) significantly enhanced the degradation of hydrocortisone (HC) to 99%, betamethasone (BT) to 99%, fluocinolone acetonide (FA) to 98%, and clobetasol propionate (CP) to 82% in 5 days with a mixing ratio of 1:1 (g TS sludge/g dw manure) at 55 °C and initial pH of 7. Simultaneously, sludge reduction was increased by 30% and value-added volatile fatty acid (VFA) production was improved by 40%. Even a high GC content of biomass (3.6 mg/g TS) did not impact both sludge hydrolysis and acidification. The amendment of WAS with CM increased soluble organic carbon, Ca2+, and relative abundance of anaerobes (Eubacterium) associated with organic compound degradation. Furthermore, 44 transformation products of HC, BT, FA, and CP with lower lipophilicity and toxicity were identified, indicating possible degradation pathways including hydroxylation, ketonization, ring cleavage, defluorination, hydrogenation, methylation, and de-esterification. Overall, this study provides a practical way to control GC pollution and simultaneously promote waste reduction and VFA production. Animal manure type as an overlooked factor for influencing co-fermentation performance and pollutant degradation was also highlighted.
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Affiliation(s)
- Ai Zhang
- College of Environmental Science and Engineering, Donghua University, 2999, North Renmin Road, Shanghai, 201620, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, China
| | - Jinling He
- College of Environmental Science and Engineering, Donghua University, 2999, North Renmin Road, Shanghai, 201620, China
| | - Yuye Shen
- College of Environmental Science and Engineering, Donghua University, 2999, North Renmin Road, Shanghai, 201620, China
| | - Xianbao Xu
- College of Environmental Science and Engineering, Donghua University, 2999, North Renmin Road, Shanghai, 201620, China
| | - Yanan Liu
- College of Environmental Science and Engineering, Donghua University, 2999, North Renmin Road, Shanghai, 201620, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, China
| | - Yongmei Li
- Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, China; College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, China
| | - Shimin Wu
- Department of Chemical & Environmental Engineering, University of Arizona, Tucson, AZ, 85721, United States
| | - Gang Xue
- College of Environmental Science and Engineering, Donghua University, 2999, North Renmin Road, Shanghai, 201620, China
| | - Xiang Li
- College of Environmental Science and Engineering, Donghua University, 2999, North Renmin Road, Shanghai, 201620, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, China.
| | - Jacek Makinia
- Faculty of Civil and Environmental Engineering, Gdansk University of Technology, Ul. Narutowicza 11/12, 80-233, Gdansk, Poland
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Oxidative degradation of acetaminophen using superoxide ion generated in ionic liquid/aprotic solvent binary system. Sep Purif Technol 2021. [DOI: 10.1016/j.seppur.2021.118730] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/20/2023]
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10
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Lennox RJ, Westrelin S, Souza AT, Šmejkal M, Říha M, Prchalová M, Nathan R, Koeck B, Killen S, Jarić I, Gjelland K, Hollins J, Hellstrom G, Hansen H, Cooke SJ, Boukal D, Brooks JL, Brodin T, Baktoft H, Adam T, Arlinghaus R. A role for lakes in revealing the nature of animal movement using high dimensional telemetry systems. MOVEMENT ECOLOGY 2021; 9:40. [PMID: 34321114 PMCID: PMC8320048 DOI: 10.1186/s40462-021-00244-y] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/20/2020] [Accepted: 02/11/2021] [Indexed: 05/13/2023]
Abstract
Movement ecology is increasingly relying on experimental approaches and hypothesis testing to reveal how, when, where, why, and which animals move. Movement of megafauna is inherently interesting but many of the fundamental questions of movement ecology can be efficiently tested in study systems with high degrees of control. Lakes can be seen as microcosms for studying ecological processes and the use of high-resolution positioning systems to triangulate exact coordinates of fish, along with sensors that relay information about depth, temperature, acceleration, predation, and more, can be used to answer some of movement ecology's most pressing questions. We describe how key questions in animal movement have been approached and how experiments can be designed to gather information about movement processes to answer questions about the physiological, genetic, and environmental drivers of movement using lakes. We submit that whole lake telemetry studies have a key role to play not only in movement ecology but more broadly in biology as key scientific arenas for knowledge advancement. New hardware for tracking aquatic animals and statistical tools for understanding the processes underlying detection data will continue to advance the potential for revealing the paradigms that govern movement and biological phenomena not just within lakes but in other realms spanning lands and oceans.
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Affiliation(s)
- Robert J Lennox
- Laboratory for Freshwater Ecology and Inland Fisheries (LFI) at NORCE Norwegian Research Centre, Nygårdsporten 112, 5008, Bergen, Norway.
| | - Samuel Westrelin
- INRAE, Aix Marseille Univ, Pôle R&D ECLA, RECOVER, 3275 Route de Cézanne - CS 40061, 13182 Cedex 5, Aix-en-Provence, France
| | - Allan T Souza
- Institute of Hydrobiology, Biology Centre of the Czech Academy of Sciences, České Budějovice, Czech Republic
| | - Marek Šmejkal
- Institute of Hydrobiology, Biology Centre of the Czech Academy of Sciences, České Budějovice, Czech Republic
| | - Milan Říha
- Institute of Hydrobiology, Biology Centre of the Czech Academy of Sciences, České Budějovice, Czech Republic
| | - Marie Prchalová
- Institute of Hydrobiology, Biology Centre of the Czech Academy of Sciences, České Budějovice, Czech Republic
| | - Ran Nathan
- Movement Ecology Lab, Department of Ecology, Evolution, and Behavior, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, 102 Berman Bldg, Edmond J. Safra Campus at Givat Ram, 91904, Jerusalem, Israel
| | - Barbara Koeck
- Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Graham Kerr Building, Glasgow, G12 8QQ, UK
| | - Shaun Killen
- Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Graham Kerr Building, Glasgow, G12 8QQ, UK
| | - Ivan Jarić
- Institute of Hydrobiology, Biology Centre of the Czech Academy of Sciences, České Budějovice, Czech Republic
- Faculty of Science, Department of Ecosystem Biology, University of South Bohemia, České Budějovice, Czech Republic
| | - Karl Gjelland
- Norwegian Institute of Nature Research, Tromsø, Norway
| | - Jack Hollins
- Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Graham Kerr Building, Glasgow, G12 8QQ, UK
- University of Windsor, Windsor, ON, Canada
| | - Gustav Hellstrom
- Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden
| | - Henry Hansen
- Karlstads University, Universitetsgatan 2, 651 88, Karlstad, Sweden
- Department of Biology and Ecology of Fishes, Leibniz Institute of Freshwater Ecology and Inland Fisheries, Bergen, Germany
| | - Steven J Cooke
- Fish Ecology and Conservation Physiology Laboratory, Department of Biology, Carleton University, Ottawa, ON, Canada
| | - David Boukal
- Faculty of Science, Department of Ecosystem Biology, University of South Bohemia, České Budějovice, Czech Republic
- Institute of Entomology, Biology Centre of the Czech Academy of Sciences, České Budějovice, Czech Republic
| | - Jill L Brooks
- Fish Ecology and Conservation Physiology Laboratory, Department of Biology, Carleton University, Ottawa, ON, Canada
| | - Tomas Brodin
- Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden
| | - Henrik Baktoft
- Technical University of Denmark, Vejlsøvej 39, Building Silkeborg-039, 8600, Silkeborg, Denmark
| | - Timo Adam
- Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany
| | - Robert Arlinghaus
- Department of Biology and Ecology of Fishes, Leibniz Institute of Freshwater Ecology and Inland Fisheries, Bergen, Germany
- Division of Integrative Fisheries Management, Humboldt-Universität zu Berlin, Bergen, Germany
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11
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Cha J, Hong S, Lee J, Gwak J, Kim M, Kim T, Hur J, Giesy JP, Khim JS. Novel polar AhR-active chemicals detected in sediments of an industrial area using effect-directed analysis based on in vitro bioassays with full-scan high resolution mass spectrometric screening. THE SCIENCE OF THE TOTAL ENVIRONMENT 2021; 779:146566. [PMID: 34030261 DOI: 10.1016/j.scitotenv.2021.146566] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/06/2020] [Revised: 02/22/2021] [Accepted: 03/14/2021] [Indexed: 06/12/2023]
Abstract
Studies investigating aryl hydrocarbon receptor (AhR)-active compounds in the environment typically focus on non- and mid-polar substances, such as PAHs; while, information on polar AhR agonists remains limited. Here, we identified polar AhR agonists in sediments collected from the inland creeks of an industrialized area (Lake Sihwa, Korea) using effect-directed analysis combined with full-scan screening analysis (FSA; using LC-QTOFMS). Strong AhR-mediated potencies were observed for the polar and latter fractions of RP-HPLC (F3.5-F3.8) from sediment organic extracts in the H4IIE-luc in vitro bioassays. FSA was performed on the corresponding fractions. Twenty-eight tentative AhR agonists were chosen using a five-step process. Toxicological confirmation using bioassay revealed that canrenone, rutaecarpine, ciprofloxacin, mepanipyrim, genistein, protopine, hydrocortisone, and medroxyprogesterone were significantly active. The relative potencies of these AhR-active compounds compared to that of benzo[a]pyrene ranged from 0.00002 to 2.0. Potency balance analysis showed that polar AhR agonists explained, on average, ~6% of total AhR-mediated potencies in samples. Some novel polar AhR agonists also exhibited endocrine-disrupting potentials capable of binding to estrogen and glucocorticoid receptors, as identified by QSAR modeling. In conclusion, the focused studies on distributions, sources, fate, and ecotoxicological effects of novel polar AhR agonists in the environment are necessary.
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Affiliation(s)
- Jihyun Cha
- Department of Ocean Environmental Sciences, Chungnam National University, Daejeon 34134, Republic of Korea
| | - Seongjin Hong
- Department of Ocean Environmental Sciences, Chungnam National University, Daejeon 34134, Republic of Korea.
| | - Junghyun Lee
- School of Earth and Environmental Sciences & Research Institute of Oceanography, Seoul National University, Seoul 08826, Republic of Korea
| | - Jiyun Gwak
- Department of Ocean Environmental Sciences, Chungnam National University, Daejeon 34134, Republic of Korea
| | - Mungi Kim
- Department of Ocean Environmental Sciences, Chungnam National University, Daejeon 34134, Republic of Korea
| | - Taewoo Kim
- School of Earth and Environmental Sciences & Research Institute of Oceanography, Seoul National University, Seoul 08826, Republic of Korea
| | - Jin Hur
- Department of Environment & Energy, Sejong University, Seoul 05006, Republic of Korea
| | - John P Giesy
- Department of Veterinary Biomedical Sciences & Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan S7N5B3, Canada; Department of Environmental Science, Baylor University, Waco, TX 76798-7266, United States
| | - Jong Seong Khim
- School of Earth and Environmental Sciences & Research Institute of Oceanography, Seoul National University, Seoul 08826, Republic of Korea.
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12
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McGain F, Muret J, Lawson C, Sherman JD. Environmental sustainability in anaesthesia and critical care. Br J Anaesth 2020; 125:680-692. [PMID: 32798068 PMCID: PMC7421303 DOI: 10.1016/j.bja.2020.06.055] [Citation(s) in RCA: 193] [Impact Index Per Article: 38.6] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/16/2020] [Revised: 05/29/2020] [Accepted: 06/13/2020] [Indexed: 01/17/2023] Open
Abstract
The detrimental health effects of climate change continue to increase. Although health systems respond to this disease burden, healthcare itself pollutes the atmosphere, land, and waterways. We surveyed the 'state of the art' environmental sustainability research in anaesthesia and critical care, addressing why it matters, what is known, and ideas for future work. Focus is placed upon the atmospheric chemistry of the anaesthetic gases, recent work clarifying their relative global warming potentials, and progress in waste anaesthetic gas treatment. Life cycle assessment (LCA; i.e. 'cradle to grave' analysis) is introduced as the definitive method used to compare and contrast ecological footprints of products, processes, and systems. The number of LCAs within medicine has gone from rare to an established body of knowledge in the past decade that can inform doctors of the relative ecological merits of different techniques. LCAs with practical outcomes are explored, such as the carbon footprint of reusable vs single-use anaesthetic devices (e.g. drug trays, laryngoscope blades, and handles), and the carbon footprint of treating an ICU patient with septic shock. Avoid, reduce, reuse, recycle, and reprocess are then explored. Moving beyond routine clinical care, the vital influences that the source of energy (renewables vs fossil fuels) and energy efficiency have in healthcare's ecological footprint are highlighted. Discussion of the integral roles of research translation, education, and advocacy in driving the perioperative and critical care environmental sustainability agenda completes this review.
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Affiliation(s)
| | - Jane Muret
- French Society of Anaesthesia and Intensive Care (SFAR), Institut Curie PSL Research University, Paris, France
| | - Cathy Lawson
- Newcastle upon Tyne Hospitals, Newcastle upon Tyne, England, UK
| | - Jodi D Sherman
- Department of Anesthesiology, Yale School of Medicine, Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA
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13
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Lin C, Gong J, Zhou Y, Chen D, Chen Y, Yang J, Li Q, Wu C, Tang H. Spatiotemporal distribution, source apportionment, and ecological risk of corticosteroids in the urbanized river system of Guangzhou, China. THE SCIENCE OF THE TOTAL ENVIRONMENT 2020; 706:135693. [PMID: 31791762 DOI: 10.1016/j.scitotenv.2019.135693] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/10/2019] [Revised: 11/15/2019] [Accepted: 11/21/2019] [Indexed: 06/10/2023]
Abstract
We investigated the occurrence and distribution of 24 selected corticosteroids (CSs) in the surface water of the Zhujiang River (ZR) system in Guangzhou, a highly urbanized river system receiving both treated and untreated municipal wastewater effluents. Twenty-two and sixteen CSs were detected in the tributaries and the main stream of the ZR system, and their concentrations ranged from less than the method quantification limit (fluticasone propionate) to 94 ng/L (clobetasone butyrate) and from 0.24 ng/L (cortisol) to 7.2 ng/L (clobetasone butyrate), respectively. We observed higher total CSs (∑CSs) concentrations in the tributaries (11-396 ng/L) relative to the main stream (5.5-33 ng/L) due to their proximity to densely populated residential areas. ∑CSs concentrations in the dry season were generally higher than those in the wet season due to low dilution from decreased river discharge. Principal component analysis and multiple linear regression analysis identified untreated domestic sewage to be the dominant source of CSs (t2, contribution rate: 42.7%) in the urban rivers. Additional source contributions were from naturally attenuated treated and/or raw sewage (t1, 21.5%) and effluents from wastewater treatment plants (t3, 26.7%). CSs contribution was dominated by t2 in the dry season, and the contributions from t1, t2, and t3 showed no significant difference in the wet season. Risk assessment inferred that the ZR system is at medium to high ecological risk from CSs and is therefore a potential threat to the health of aquatic ecosystems. To prevent CSs pollution, our results demonstrate the need to develop effective control strategies to minimize the discharge of untreated waste to nearby rivers and to improve the capacity of wastewater treatment plants in Guangzhou. Further, we demonstrate that the concentrations of cortisone and fludrocortisone acetate are effective chemical indicators to estimate the level of natural and synthetic CSs contamination in urban rivers.
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Affiliation(s)
- Canyuan Lin
- Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China; Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China
| | - Jian Gong
- Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China; Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China.
| | - Yongshun Zhou
- Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China; Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China
| | - Diyun Chen
- Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China; Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China
| | - Yongheng Chen
- Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China; Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China
| | - Juan Yang
- Institute of Environmental Remediation and Human Health, Southwest Forestry University, Kunming 650224, China.
| | - Qiang Li
- School of life Sciences, Guangzhou University, Guangzhou 510006, China
| | - Cuiqin Wu
- Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China; Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China
| | - Hongmei Tang
- Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China; Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China
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14
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McGain F, Ma SC, Burrell RH, Percival VG, Roessler P, Weatherall AD, Weber IA, Kayak EA. Why be sustainable? The Australian and New Zealand College of Anaesthetists Professional Document PS64: Statement on Environmental Sustainability in Anaesthesia and Pain Medicine Practice and its accompanying background paper. Anaesth Intensive Care 2019; 47:413-422. [PMID: 31684744 DOI: 10.1177/0310057x19884075] [Citation(s) in RCA: 13] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/16/2022]
Abstract
Healthcare’s environmental sustainability is increasingly an area of research and advocacy focus. The Australian and New Zealand College of Anaesthetists (ANZCA) has produced a professional document, PS64, Statement on Environmental Sustainability in Anaesthesia and Pain Medicine Practice, and a background paper, PS64 BP. The purpose of the statement is to affirm ANZCA’s commitment to environmental sustainability and support anaesthetists in promoting environmentally sustainable work practices. This article presents the main features of PS64 and its background paper, and the associated supporting evidence. The healthcare sector is highly interconnected with activities that emit pollution to air, water and soils, considerably adding to humanity’s collective ecological footprint. As anaesthetists, we are uniquely high-carbon doctors due to our work anaesthetising with greenhouse gases (particularly desflurane and nitrous oxide) and our exposure and contribution to large amounts of resource and energy use and waste generation in operating theatres. Discussion is made of the improving research base of anaesthetic life-cycle assessments—that is, cradle-to-grave studies of how much energy, water and so on a product or process requires throughout its entire life. Thereafter, reducing, reusing and recycling as well as water use are examined. Ongoing research efforts within environmentally sustainable anaesthesia are highlighted. Environmentally sustainable anaesthesia requires scholarship, health advocacy, leadership, communication and collaboration. The focus is placed on practical initiatives within PS64 and the background paper that can be achieved by all anaesthetists striving towards more sustainable healthcare practices that reduce waste, reap financial benefits and improve health.
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Affiliation(s)
- Forbes McGain
- Department of Anaesthesia and Intensive Care, Western Health, Footscray Hospital, Melbourne, Australia
| | - Scott Cy Ma
- Department of Children's Anaesthesia, Women's and Children's Hospital, Adelaide, Australia
| | - Rob H Burrell
- Department of Anaesthesia and Intensive Care, Middlemore Hospital, Auckland, New Zealand
| | | | - Peter Roessler
- Australian and New Zealand College of Anaesthetists, Melbourne, Australia
| | | | - Ingo A Weber
- Department of Anaesthesia and Pain Medicine, Flinders University of South Australia, Adelaide, Australia
| | - Eugenie A Kayak
- Department of Anaesthesia, Alfred Health, Melbourne, Australia
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15
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Gong J, Lin C, Xiong X, Chen D, Chen Y, Zhou Y, Wu C, Du Y. Occurrence, distribution, and potential risks of environmental corticosteroids in surface waters from the Pearl River Delta, South China. ENVIRONMENTAL POLLUTION (BARKING, ESSEX : 1987) 2019; 251:102-109. [PMID: 31071626 DOI: 10.1016/j.envpol.2019.04.110] [Citation(s) in RCA: 32] [Impact Index Per Article: 5.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/30/2018] [Revised: 04/23/2019] [Accepted: 04/23/2019] [Indexed: 05/25/2023]
Abstract
The occurrence, spatiotemporal distribution, and potential risks of 21 glucocorticoids (GCs) and 3 mineralocorticoids (MCs) in four rivers were studied by investigating the surface waters from the Pearl River Delta (PRD), South China. These environmental corticosteroids (ECs) were commonly present in the river surface waters with average concentrations varying from <0.17 ng/L for fluticasone propionate to 5.6 ng/L for clobetasone butyrate; and cortisone had the highest concentration, 32.9 ng/L. The total ECs ranged in concentration from undetectable to 83.3 ng/L, with a mean and median of 8.1 ng/L and 4.8 ng/L, respectively. Spatially the total EC concentration levels in the Pearl River system occurred in the following order: Zhujiang River (ZR) > Dongjiang River (DR) > Shiziyang waterway (SW) > Beijiang River (BR). These levels generally demonstrated a trend of increasing from upstream to midstream or downstream then attenuating toward the estuary. Considerable seasonal variations in the ECs differed among rivers. Higher ECs concentrations in winter were mostly found in the ZR, whereas lower levels were found in the DR. Moreover, the temporal variations of the ECs were marginal in the BR and SW. These spatiotemporal distributions of the ECs might have been simultaneously influenced by pollution sources derived from anthropogenic activities and river hydrologic conditions. Correlation analyses indicated that dissolved organic carbon (DOC) could play a key role in the occurrence and distribution of ECs in an aquatic environment. Risk assessment demonstrated that the occurrence of ECs might have posed medium to high risk to aquatic organisms in the Pearl River.
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Affiliation(s)
- Jian Gong
- Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China; Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China.
| | - Canyuan Lin
- Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China; Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China
| | - Xiaoping Xiong
- Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China; Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China
| | - Diyun Chen
- Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China; Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China
| | - Yongheng Chen
- Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China; Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China
| | - Yongshun Zhou
- Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China; Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China
| | - Cuiqin Wu
- Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China; Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China
| | - Yongming Du
- Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China
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16
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Weizel A, Schlüsener MP, Dierkes G, Ternes TA. Occurrence of Glucocorticoids, Mineralocorticoids, and Progestogens in Various Treated Wastewater, Rivers, and Streams. ENVIRONMENTAL SCIENCE & TECHNOLOGY 2018; 52:5296-5307. [PMID: 29580053 DOI: 10.1021/acs.est.7b06147] [Citation(s) in RCA: 74] [Impact Index Per Article: 10.6] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/07/2023]
Abstract
In the current study a high sensitive analytical method was developed for the determination of 60 steroids including glucocorticoids (GC), mineralocorticoids (MC), and progestogens (PG) in WWTP effluents and surface water using liquid chromatography with tandem mass spectrometry detection (LC-MS/MS). The limits of quantification (LOQ) ranged between 0.02 ng/L (cortisone) to 0.5 ng/L (drospirenone) in surface water and from 0.05 ng/L (betamethasone) to 5 ng/L (chlormadinone) in treated wastewater. After optimization, the developed method was applied to WWTP effluents, rivers, and streams around Germany. Numerous steroids have been detected during the sampling campaign and predominant analytes from all steroid types were determined. Moreover, the occurrence of dienogest, mometasone furoate, flumethasone pivalate, and the metabolites 6β-hydroxy dienogest, 6β-hydroxy triamcinolone acetonide, 7α-thiomethyl spironolactone, and 11α-hydroxy canrenone is reported for the first time. In addition, this study revealed the ubiquitous presence of topically applied GC monoesters betamethasone propionate, betamethasone valerate, and 6α-methylprednisolone propionate in WWTP effluents and surface water.
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Affiliation(s)
- Alexander Weizel
- Federal Institute of Hydrology , Department of Aquatic Chemistry , 56068 Koblenz , Germany
| | - Michael P Schlüsener
- Federal Institute of Hydrology , Department of Aquatic Chemistry , 56068 Koblenz , Germany
| | - Georg Dierkes
- Federal Institute of Hydrology , Department of Aquatic Chemistry , 56068 Koblenz , Germany
| | - Thomas A Ternes
- Federal Institute of Hydrology , Department of Aquatic Chemistry , 56068 Koblenz , Germany
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17
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Matlin SA, Mehta G, Krief A, Hopf H. The Chemical Sciences and Health: Strengthening Synergies at a Vital Interface. ACS OMEGA 2017; 2:6819-6821. [PMID: 30023534 PMCID: PMC6045363 DOI: 10.1021/acsomega.7b01463] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/19/2023]
Abstract
The indispensable contributions to health made by the chemical sciences have become increasingly constrained by three systemic factors. These involve fragmentations: in the way that the chemicals sciences are structured, practiced, and inter-related to aspects of health; in the combination of public and private efforts delivering medicinal products; and in the regulatory systems which oversee health-related issues across health, food, and the environment. Interlinked systemic reforms are advocated, involving (1) recontextualization of the chemistry/health interface through creating a recognized field of "the chemical sciences and health"; (2) determined and comprehensive efforts, by countries wishing to retain or strengthen their pharmaceutical development capacities, to reinforce their education, research, and innovation eco-systems; and (3) adoption of an integrated approach to the regulation of pharmaceuticals, food, and the environment.
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Affiliation(s)
- Stephen A. Matlin
- Institute
of Global Health Innovation, Imperial College
London, London SW7 2AZ, U.K.
- International
Organization for Chemical Sciences in Development, 61 rue de Bruxelles, B-5000 Namur, Belgium
- E-mail:
| | - Goverdhan Mehta
- International
Organization for Chemical Sciences in Development, 61 rue de Bruxelles, B-5000 Namur, Belgium
- School
of Chemistry, University of Hyderabad, Hyderabad 500046, India
| | - Alain Krief
- International
Organization for Chemical Sciences in Development, 61 rue de Bruxelles, B-5000 Namur, Belgium
- Chemistry
Department, Namur University, B-5000 Namur, Belgium
- HEJ
Research Institute, University of Karachi, Karachi 75270, Pakistan
| | - Henning Hopf
- International
Organization for Chemical Sciences in Development, 61 rue de Bruxelles, B-5000 Namur, Belgium
- Institute
of Organic Chemistry, Technische Universität
Braunschweig, D-38106 Braunschweig, Germany
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18
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Kamba PF, Kaggwa B, Munanura EI, Okurut T, Kitutu FE. Why regulatory indifference towards pharmaceutical pollution of the environment could be a missed opportunity in public health protection. a holistic view. Pan Afr Med J 2017; 27:77. [PMID: 28819498 PMCID: PMC5554629 DOI: 10.11604/pamj.2017.27.77.10973] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/15/2016] [Accepted: 01/22/2017] [Indexed: 12/05/2022] Open
Abstract
The last generation has witnessed bludgeoning of the world's population, a spike in disease burden, and unprecedented levels of pharmaceutical consumption and production. Unfortunately, pharmaceuticals have left their industrial and household confines and leaked into the environment. Pharmaceuticals are now major environmental pollutants, and are ubiquitous in waters and soils. Unlike other environmental contaminants, pharmaceutical pollutants are not yet regulated globally, simply because acute risk assessments show insignificant human health hazard. But the pitfalls of pharmaceutical pollutants extend beyond acute effects to delayed effects from bioaccumulation, amplified effects from drug-drug interactions, exacerbation of drug resistance, and reduction in aquatic and terrestrial food production. Therefore, ignoring pharmaceutical pollutants deprives society of holistic public health protection.
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Affiliation(s)
- Pakoyo Fadhiru Kamba
- Department of Pharmacy, School of Health Sciences, Makerere University, P.O Box 7072, Kampala, Uganda
| | - Bruhan Kaggwa
- Department of Pharmacy, School of Health Sciences, Makerere University, P.O Box 7072, Kampala, Uganda
| | - Edson Ireeta Munanura
- Department of Pharmacy, School of Health Sciences, Makerere University, P.O Box 7072, Kampala, Uganda
| | - Tom Okurut
- National Environment Management Authority (NEMA), Plot 17/19/21 Jinja Road, Kampala, Uganda
| | - Freddy Eric Kitutu
- Department of Pharmacy, School of Health Sciences, Makerere University, P.O Box 7072, Kampala, Uganda
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19
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Kaniyil S, Krishnadas A, Parathody AK, Ramadas KT. Financial Implications of Intravenous Anesthetic Drug Wastage in Operation Room. Anesth Essays Res 2017; 11:304-308. [PMID: 28663611 PMCID: PMC5490106 DOI: 10.4103/0259-1162.186596] [Citation(s) in RCA: 8] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/06/2022] Open
Abstract
Background and Objectives: Anesthetic drugs and material wastage are common in operation rooms (ORs). In this era of escalating health-care expenditure, cost reduction strategies are highly relevant. The aim of this study was to assess the amount of daily intravenous anesthetic drug wastage from major ORs and to estimate its financial burden. Any preventive measures to minimize drug wastage are also looked for. Methods: It was a prospective study conducted at the major ORs of a tertiary care hospital after getting the Institutional Research Committee approval. The total amount of all drugs wasted at the end of a surgical day from each major OR was audited for five nonconsecutive weeks. Drug wasted includes the drugs leftover in the syringes unutilized and opened vials/ampoules. The total cost of the wasted drugs and average daily loss were estimated. Results: The drugs wasted in large quantities included propofol, thiopentone sodium, vecuronium, mephentermine, lignocaine, midazolam, atropine, succinylcholine, and atracurium in that order. The total cost of the wasted drugs during the study period was Rs. 59,631.49, and the average daily loss was Rs. 1987.67. The average daily cost of wasted drug was maximum for vecuronium (Rs. 699.93) followed by propofol (Rs. 662.26). Interpretation and Conclusions: Financial implications of anesthetic drug wastage can be significant. Propofol and vecuronium contributed maximum to the financial burden. Suggestions for preventive measures to minimize the wastage include education of staff and residents about the cost of drugs, emphasizing on the judicial use of costly drugs.
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Affiliation(s)
- Suvarna Kaniyil
- Department of Anesthesia, Government Medical College, Kozhikode, Kerala, India
| | - A Krishnadas
- Department of Anesthesia, Government Medical College, Kozhikode, Kerala, India
| | | | - K T Ramadas
- Department of Anesthesia, Government Medical College, Kozhikode, Kerala, India
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20
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Brodin T, Nordling J, Lagesson A, Klaminder J, Hellström G, Christensen B, Fick J. Environmental relevant levels of a benzodiazepine (oxazepam) alters important behavioral traits in a common planktivorous fish, (Rutilus rutilus). JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH. PART A 2017; 80:963-970. [PMID: 28829722 DOI: 10.1080/15287394.2017.1352214] [Citation(s) in RCA: 48] [Impact Index Per Article: 6.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/02/2023]
Abstract
Environmental pollution by pharmaceuticals is increasingly recognized as a major threat to aquatic ecosystems worldwide. A complex mix of pharmaceuticals enters waterways via treated wastewater effluent and many remain biochemically active after the drugs reach aquatic systems. However, to date little is known regarding the ecological effects that might arise following pharmaceutical contamination of aquatic environments. One group of particular concern is behaviorally modifying pharmaceuticals as seemingly minor changes in behavior may initiate marked ecological consequences. The aim of this study was to examine the influence of a benzodiazepine anxiolytic drug (oxazepam) on key behavioral traits in wild roach (Rutilus rutilus) at concentrations similar to those encountered in effluent surface waters. Roach exposed to water with high concentrations of oxazepam (280 µg/L) exhibited increased boldness, while roach at low treatment (0.84 µg/L) became bolder and more active compared to control fish. Our results reinforce the notion that anxiolytic drugs may be affecting fish behavior in natural systems, emphasizing the need for further research on ecological impacts of pharmaceuticals in aquatic systems and development of new tools to incorporate ecologically relevant behavioral endpoints into ecotoxicological risk assessment.
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Affiliation(s)
- Tomas Brodin
- a Department of Ecology and Environmental Science , Umeå University , Umeå , Sweden
| | - Johanna Nordling
- a Department of Ecology and Environmental Science , Umeå University , Umeå , Sweden
| | - Annelie Lagesson
- a Department of Ecology and Environmental Science , Umeå University , Umeå , Sweden
| | - Jonatan Klaminder
- a Department of Ecology and Environmental Science , Umeå University , Umeå , Sweden
| | - Gustav Hellström
- b Department of Wildlife , Fish, and Environmental Studies, Swedish University of Agricultural Sciences , Umeå , Sweden
| | - Bent Christensen
- a Department of Ecology and Environmental Science , Umeå University , Umeå , Sweden
| | - Jerker Fick
- c Department of Chemistry , Umeå University , Umeå , Sweden
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Pereira CDS, Maranho LA, Cortez FS, Pusceddu FH, Santos AR, Ribeiro DA, Cesar A, Guimarães LL. Occurrence of pharmaceuticals and cocaine in a Brazilian coastal zone. THE SCIENCE OF THE TOTAL ENVIRONMENT 2016; 548-549:148-154. [PMID: 26802343 DOI: 10.1016/j.scitotenv.2016.01.051] [Citation(s) in RCA: 113] [Impact Index Per Article: 12.6] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/05/2015] [Revised: 01/09/2016] [Accepted: 01/09/2016] [Indexed: 05/20/2023]
Abstract
The present study determined environmental concentrations of pharmaceuticals, cocaine, and the main human metabolite of cocaine in seawater sampled from a subtropical coastal zone (Santos, Brazil). The Santos Bay is located in a metropolitan region and receives over 7367m(3) of wastewater per day. Five sample points under strong influence of the submarine sewage outfall were chosen. Through quantitative analysis by LC-MS/MS, 33 compounds were investigated. Seven pharmaceuticals (atenolol, acetaminophen, caffeine, losartan, valsartan, diclofenac, and ibuprofen), an illicit drug (cocaine), and its main human metabolite (benzoylecgonine) were detected at least once in seawater sampled from Santos Bay at concentrations that ranged from ng·L(-1) to μg·L(-1). In light of the possibility of bioaccumulation and harmful effects, the high concentrations of pharmaceuticals and cocaine found in this marine subtropical ecosystem are of environmental concern.
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Affiliation(s)
- Camilo D Seabra Pereira
- Departamento de Ciências do Mar, Universidade Federal de São Paulo, Av. Saldanha da Gama n.89, 11030-400 Santos, SP, Brazil; Laboratório de Ecotoxicologia, Universidade Santa Cecília, Rua Oswaldo Cruz 266, 11045-907 Santos, SP, Brazil.
| | - Luciane A Maranho
- Departamento de Ciências do Mar, Universidade Federal de São Paulo, Av. Saldanha da Gama n.89, 11030-400 Santos, SP, Brazil
| | - Fernando S Cortez
- Laboratório de Ecotoxicologia, Universidade Santa Cecília, Rua Oswaldo Cruz 266, 11045-907 Santos, SP, Brazil
| | - Fabio H Pusceddu
- Laboratório de Ecotoxicologia, Universidade Santa Cecília, Rua Oswaldo Cruz 266, 11045-907 Santos, SP, Brazil
| | - Aldo R Santos
- Laboratório de Ecotoxicologia, Universidade Santa Cecília, Rua Oswaldo Cruz 266, 11045-907 Santos, SP, Brazil
| | - Daniel A Ribeiro
- Departamento de Biociências, Universidade Federal de São Paulo, Av. Ana Costa 95, 11060-001 Santos, SP, Brazil
| | - Augusto Cesar
- Departamento de Ciências do Mar, Universidade Federal de São Paulo, Av. Saldanha da Gama n.89, 11030-400 Santos, SP, Brazil; Laboratório de Ecotoxicologia, Universidade Santa Cecília, Rua Oswaldo Cruz 266, 11045-907 Santos, SP, Brazil
| | - Luciana L Guimarães
- Laboratório de Pesquisa em Produtos Naturais, PPG em Sustentabilidade de Ecossistemas Costeiros e Marinhos, Universidade Santa Cecília, Rua Cesário Mota 8, 11045-040 Santos, SP, Brazil
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Zhang Q, Cheng J, Xin Q. Effects of tetracycline on developmental toxicity and molecular responses in zebrafish (Danio rerio) embryos. ECOTOXICOLOGY (LONDON, ENGLAND) 2015; 24:707-19. [PMID: 25588674 DOI: 10.1007/s10646-015-1417-9] [Citation(s) in RCA: 107] [Impact Index Per Article: 10.7] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Accepted: 01/05/2015] [Indexed: 05/25/2023]
Abstract
The extensive use of pharmaceuticals has resulted in the intensive contamination of water bodies. Tetracycline is a type of antibiotic and its potential toxicity is causing environmental concern. The effects of developmental toxicity and the mechanisms of tetracycline on fish embryos are not well understood. Zebrafish embryos are used in this study to investigate the developmental toxicity of this compound. Four hour post-fertilization (hpf) zebrafish embryos are exposed to different concentrations of tetracycline until 96 hpf. The larvae display developmental delay phenotypes, including hatching delay, shorter body length, increased yolk sac area and uninflated swim bladder upon exposure to tetracycline. Delayed yolk sac absorption and swim bladder deficiency at 96 hpf are observed in the zebrafish larvae upon exposure to 20 μg/L of tetracycline. To test whether tetracycline causes oxidative damage and the resulting oxidative stress-induced apoptosis, the generation of reactive oxygen species (ROS), Acridine Orange staining and real time polymerase chain reaction have been performed in this study. The results indicate that tetracycline exposure results in significant increases in ROS production and cell apoptosis, mainly in the tail areas at 96 hpf. The gene expression pattern demonstrates that tetracycline induces ROS which causes apoptosis in the zebrafish larvae, and the results also indicate that caspase-dependent apoptotic pathways may greatly contribute to tetracycline-induced apoptosis in the early-life stages of the zebrafish. In addition, we have investigated the effects of tetracycline on marker genes related to resistance mechanisms and gene regulating drug biotransformation. The results of these gene expression studies indicate that tetracycline could induce zebrafish to resist pharmaceuticals and Cytochrome P450s that are involved in the biotransformation of tetracycline in zebrafish larvae. The overall results indicate that tetracycline can produce oxidative stress and induce apoptosis, which brings about significant developmental delay in zebrafish embryos.
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Affiliation(s)
- Qiang Zhang
- State Key Laboratory of Estuarine and Coastal Research, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China
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Carney Almroth BM, Gunnarsson LM, Cuklev F, Fick J, Kristiansson E, Larsson DGJ. Waterborne beclomethasone dipropionate affects the physiology of fish while its metabolite beclomethasone is not taken up. THE SCIENCE OF THE TOTAL ENVIRONMENT 2015; 511:37-46. [PMID: 25527967 DOI: 10.1016/j.scitotenv.2014.12.016] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/19/2014] [Revised: 12/05/2014] [Accepted: 12/05/2014] [Indexed: 06/04/2023]
Abstract
Asthma is commonly treated with inhalable glucocorticosteroids, including beclomethasone dipropionate (BDP). This is a synthetic prodrug which is metabolized to the more active monopropionate (BMP) and free beclomethasone in humans. To evaluate potential effects of residual drugs on fish, we conducted a 14 day flow-through exposure experiment with BDP and beclomethasone using rainbow trout, and analyzed effects on plasma glucose, hepatic glutathione and catalase activity together with water and body concentrations of the BDP, BMP and beclomethasone. We also analyzed hepatic gene expression in BDP-exposed fish by microarray and quantitative PCR. Beclomethasone (up to 0.65 μg/L) was not taken up in the fish while BDP (0.65 and 0.07 μg/L) resulted in accumulation of both beclomethasone, BMP and BDP in plasma, reaching levels up to those found in humans during therapy. Accordingly, exposure to 0.65 μg/L of BDP significantly increased blood glucose as well as oxidized glutathione levels and catalase activity in the liver. Exposure to beclomethasone or the low concentration of BDP had no effect on these endpoints. Both exposure concentrations of BDP resulted in significantly higher transcript abundance of phosphoenolpyruvate carboxykinase involved in gluconeogenesis, and of genes involved in immune responses. As only the rapidly metabolized prodrug was potent in fish, the environmental risks associated with the use of BDP are probably small. However, the observed physiological effects in fish of BDP at plasma concentrations known to affect human physiology provides valuable input to the development of read-across approaches in the identification of pharmaceuticals of environmental concern.
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Affiliation(s)
- Bethanie M Carney Almroth
- Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Box 430, SE-405 30 Göteborg, Sweden.
| | - Lina M Gunnarsson
- Department of Infectious Diseases, Institute of Biomedicine, The Sahlgrenska Academy at the University of Gothenburg, Box 440, SE-405 30 Göteborg, Sweden.
| | - Filip Cuklev
- Genomics Core Facility at the Sahlgrenska Academy, University of Gothenburg, Box 413, SE-405 30 Göteborg, Sweden.
| | - Jerker Fick
- Department of Chemistry, Umeå University, Linaeus väg 10, SE-907 36 Umeå, Sweden.
| | - Erik Kristiansson
- Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, SE-412 96 Göteborg, Sweden.
| | - D G Joakim Larsson
- Department of Infectious Diseases, Institute of Biomedicine, The Sahlgrenska Academy at the University of Gothenburg, Box 440, SE-405 30 Göteborg, Sweden.
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Heffley JD, Comber SDW, Wheeler BW, Redshaw CH. Parameterization of pharmaceutical emissions and removal rates for use in UK predictive exposure models: steroid estrogens as a case study. ENVIRONMENTAL SCIENCE. PROCESSES & IMPACTS 2014; 16:2571-2579. [PMID: 25245643 DOI: 10.1039/c4em00374h] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/03/2023]
Abstract
Newly available prescription data has been used along with census data to develop a localised method for predicting pharmaceutical concentrations in sewage influent and effluent for England, and applied to a case study: the steroid estrogens estrone, 17β-estradiol, and 17α-ethinylestradiol in a selected catchment. The prescription data allows calculation of the mass consumed of synthetic estrogens, while use of highly localised census data improves predictions of naturally excreted estrogens by accounting for regional variations in population demographics. This serves two key purposes; to increase the accuracy of predictions in general, and to call attention to the need for more accurate predictions at a localised and/or catchment level, especially in light of newly proposed regulatory measures which may in the future require removal of steroid estrogens by sewage treatment facilities. In addition, the general lack of measured sewage works data necessitated the development of a novel approach which allowed comparison of localised predictions to average national measurements of influent and effluent. Overall in the case study catchment, estrogen predictions obtained using the model described herein were within 95% confidence intervals of measured values drawn from across the UK, with large improvements to predictions of EE2 being made compared with previous predictive methods.
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Affiliation(s)
- J D Heffley
- European Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall, UK.
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Cardoso O, Porcher JM, Sanchez W. Factory-discharged pharmaceuticals could be a relevant source of aquatic environment contamination: review of evidence and need for knowledge. CHEMOSPHERE 2014; 115:20-30. [PMID: 24602347 DOI: 10.1016/j.chemosphere.2014.02.004] [Citation(s) in RCA: 117] [Impact Index Per Article: 10.6] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/10/2013] [Revised: 02/06/2014] [Accepted: 02/08/2014] [Indexed: 05/06/2023]
Abstract
Human and veterinary active pharmaceutical ingredients (APIs) are involved in contamination of surface water, ground water, effluents, sediments and biota. Effluents of waste water treatment plants and hospitals are considered as major sources of such contamination. However, recent evidences reveal high concentrations of a large number of APIs in effluents from pharmaceutical factories and in receiving aquatic ecosystems. Moreover, laboratory exposures to these effluents and field experiments reveal various physiological disturbances in exposed aquatic organisms. Also, it seems to be relevant to increase knowledge on this route of contamination but also to develop specific approaches for further environmental monitoring campaigns. The present study summarizes available data related to the impact of pharmaceutical factory discharges on aquatic ecosystem contaminations and presents associated challenges for scientists and environmental managers.
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Affiliation(s)
- Olivier Cardoso
- Institut National de l'Environnement Industriel et des Risques (INERIS), Unité d'Ecotoxicologie in vitro et in vivo, BP2, 60550 Verneuil-en-Halatte, France; UMR-I 02 «Stress Environnementaux et BIOsurveillance des milieux aquatiques» (SEBIO), INERIS, Université de Reims & du Havre, France
| | - Jean-Marc Porcher
- Institut National de l'Environnement Industriel et des Risques (INERIS), Unité d'Ecotoxicologie in vitro et in vivo, BP2, 60550 Verneuil-en-Halatte, France; UMR-I 02 «Stress Environnementaux et BIOsurveillance des milieux aquatiques» (SEBIO), INERIS, Université de Reims & du Havre, France
| | - Wilfried Sanchez
- Institut National de l'Environnement Industriel et des Risques (INERIS), Unité d'Ecotoxicologie in vitro et in vivo, BP2, 60550 Verneuil-en-Halatte, France; UMR-I 02 «Stress Environnementaux et BIOsurveillance des milieux aquatiques» (SEBIO), INERIS, Université de Reims & du Havre, France.
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Creusot N, Aït-Aïssa S, Tapie N, Pardon P, Brion F, Sanchez W, Thybaud E, Porcher JM, Budzinski H. Identification of synthetic steroids in river water downstream from pharmaceutical manufacture discharges based on a bioanalytical approach and passive sampling. ENVIRONMENTAL SCIENCE & TECHNOLOGY 2014; 48:3649-3657. [PMID: 24579728 DOI: 10.1021/es405313r] [Citation(s) in RCA: 99] [Impact Index Per Article: 9.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/28/2023]
Abstract
A bioanalytical approach was used to identify chemical contaminants at river sites located downstream from a pharmaceutical factory, where reproductive alterations in wild fish have been previously observed. By using polar organic compound integrative samplers (POCIS) at upstream and downstream sites, biological activity profiles based on in vitro bioassays revealed the occurrence of xenobiotic and steroid-like activities, including very high glucocorticoid, antimineralocorticoid, progestogenic and pregnane X receptor (PXR)-like activities (μg standard-EQ/g of sorbent range), and weak estrogenic activity (ng E2-EQ/g of sorbent range). Chemical analyses detected up to 60 out of 118 targeted steroid and pharmaceutical compounds in the extracts. In vitro profiling of occurring individual chemicals revealed the ability of several ones to act as agonist and/or antagonist of different steroids receptors. Mass balance calculation identified dexamethasone, spironolactone, and 6-alpha-methylprednisolone as major contributors to corticosteroid activities and levonorgestrel as the main contributor to progestogenic activities. Finally, RP-HPLC based fractionation of POCIS extracts and testing activity of fractions confirmed identified compounds and further revealed the presence of other unknown active chemicals. This study is one of the first to report environmental contamination by such chemicals; their possible contribution to in situ effects on fish at the same site is suggested.
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Affiliation(s)
- Nicolas Creusot
- Institut National de l'Environnement Industriel et des Risques (INERIS), Unité Écotoxicologie in vitro et in vivo, Parc ALATA, BP2, F-60550 Verneuil-en-Halatte, France
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LaLone CA, Villeneuve DL, Cavallin JE, Kahl MD, Durhan EJ, Makynen EA, Jensen KM, Stevens KE, Severson MN, Blanksma CA, Flynn KM, Hartig PC, Woodard JS, Berninger JP, Norberg-King TJ, Johnson RD, Ankley GT. Cross-species sensitivity to a novel androgen receptor agonist of potential environmental concern, spironolactone. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 2013; 32:2528-2541. [PMID: 23881739 DOI: 10.1002/etc.2330] [Citation(s) in RCA: 18] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 03/07/2013] [Revised: 04/24/2013] [Accepted: 07/16/2013] [Indexed: 06/02/2023]
Abstract
Spironolactone is a pharmaceutical that in humans is used to treat conditions like hirsutism, various dermatologic afflictions, and female-pattern hair loss through antagonism of the androgen receptor. Although not routinely monitored in the environment, spironolactone has been detected downstream of a pharmaceutical manufacturer, indicating a potential for exposure of aquatic species. Furthermore, spironolactone has been reported to cause masculinization of female western mosquitofish, a response indicative of androgen receptor activation. Predictive methods to identify homologous proteins to the human and western mosquitofish androgen receptor suggest that vertebrates would be more susceptible to adverse effects mediated by chemicals like spironolactone that target the androgen receptor compared with invertebrate species that lack a relevant homolog. In addition, an adverse outcome pathway previously developed for activation of the androgen receptor suggests that androgen mimics can lead to reproductive toxicity in fish. To assess this, 21-d reproduction studies were conducted with 2 fish species, fathead minnow and Japanese medaka, and the invertebrate Daphnia magna. Spironolactone significantly reduced the fecundity of medaka and fathead minnows at 50 μg/L, whereas daphnia reproduction was not affected by concentrations as large as 500 μg/L. Phenotypic masculinization of females of both fish species was observed at 5 μg/L as evidenced by formation of tubercles in fathead minnows and papillary processes in Japanese medaka. Effects in fish occurred at concentrations below those reported in the environment. These results demonstrate how a priori knowledge of an adverse outcome pathway and the conservation of a key molecular target across vertebrates can be utilized to identify potential chemicals of concern in terms of monitoring and highlight potentially sensitive species and endpoints for testing.
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Affiliation(s)
- Carlie A LaLone
- US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, Duluth, Minnesota, USA
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Kamaruzaman S, Hauser PC, Sanagi MM, Ibrahim WAW, Endud S, See HH. A simple microextraction and preconcentration approach based on a mixed matrix membrane. Anal Chim Acta 2013; 783:24-30. [DOI: 10.1016/j.aca.2013.04.042] [Citation(s) in RCA: 24] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/25/2013] [Revised: 04/18/2013] [Accepted: 04/22/2013] [Indexed: 10/26/2022]
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Redshaw CH, Stahl-Timmins WM, Fleming LE, Davidson I, Depledge MH. Potential changes in disease patterns and pharmaceutical use in response to climate change. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH. PART B, CRITICAL REVIEWS 2013; 16:285-320. [PMID: 23909463 PMCID: PMC3756629 DOI: 10.1080/10937404.2013.802265] [Citation(s) in RCA: 30] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/18/2023]
Abstract
As climate change alters environmental conditions, the incidence and global patterns of human diseases are changing. These modifications to disease profiles and the effects upon human pharmaceutical usage are discussed. Climate-related environmental changes are associated with a rise in the incidence of chronic diseases already prevalent in the Northern Hemisphere, for example, cardiovascular disease and mental illness, leading to greater use of associated heavily used Western medications. Sufferers of respiratory diseases may exhibit exacerbated symptoms due to altered environmental conditions (e.g., pollen). Respiratory, water-borne, and food-borne toxicants and infections, including those that are vector borne, may become more common in Western countries, central and eastern Asia, and across North America. As new disease threats emerge, substantially higher pharmaceutical use appears inevitable, especially of pharmaceuticals not commonly employed at present (e.g., antiprotozoals). The use of medications for the treatment of general symptoms (e.g., analgesics) will also rise. These developments need to be viewed in the context of other major environmental changes (e.g., industrial chemical pollution, biodiversity loss, reduced water and food security) as well as marked shifts in human demographics, including aging of the population. To identify, prevent, mitigate, and adapt to potential threats, one needs to be aware of the major factors underlying changes in the use of pharmaceuticals and their subsequent release, deliberately or unintentionally, into the environment. This review explores the likely consequences of climate change upon the use of medical pharmaceuticals in the Northern Hemisphere.
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Affiliation(s)
- Clare H Redshaw
- European Centre for Environment and Human Health, University of Exeter Medical School, Knowledge Spa, Royal Cornwall Hospital, Truro, Cornwall, United Kingdom.
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Kim P, Park Y, Ji K, Seo J, Lee S, Choi K, Kho Y, Park J, Choi K. Effect of chronic exposure to acetaminophen and lincomycin on Japanese medaka (Oryzias latipes) and freshwater cladocerans Daphnia magna and Moina macrocopa, and potential mechanisms of endocrine disruption. CHEMOSPHERE 2012; 89:10-18. [PMID: 22560975 DOI: 10.1016/j.chemosphere.2012.04.006] [Citation(s) in RCA: 35] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/02/2011] [Revised: 03/24/2012] [Accepted: 04/04/2012] [Indexed: 05/31/2023]
Abstract
Chronic toxicity of acetaminophen and lincomycin were evaluated using freshwater organisms including two crustaceans (Daphnia magna and Moina macrocopa) and a fish (Oryzias latipes). H295R, a human adrenal cell was also used to understand the effects on steroidogenesis. In 21 d D. magna exposure, survival NOEC was found at 5.72 mg L(-1) and no reproduction related effects were noted at this level of exposure to acetaminophen, while 21 d survival or growth effects were not observed even at the highest exposure levels (153 mg L(-1)) for lincomycin. In the chronic fish toxicity test, significant reduction in juvenile survival was observed at 30 d post-hatch (dph) at 95 mg L(-1) of acetaminophen, and 0.42 mg L(-1) of lincomycin. After the exposure to both pharmaceuticals, vitellogenin levels tended to increase in male fish at 90 dph. In the eggs which were prenatally exposed to 9.5 mg L(-1) of acetaminophen, reduced hatchability was observed. The results of H295R cell assay showed that both pharmaceuticals could alter steroidogenic pathway and increase estrogenicity. Endocrine disruption potentials and their ecological implication may deserve further studies. Our observations suggest however that ecological risks of both pharmaceuticals are negligible at the concentrations currently found in the environment.
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Affiliation(s)
- PanGyi Kim
- Department of Occupational and Environmental Health, Yongin University, Yongin 449-714, Republic of Korea
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LaLone CA, Villeneuve DL, Olmstead AW, Medlock EK, Kahl MD, Jensen KM, Durhan EJ, Makynen EA, Blanksma CA, Cavallin JE, Thomas LM, Seidl SM, Skolness SY, Wehmas LC, Johnson RD, Ankley GT. Effects of a glucocorticoid receptor agonist, dexamethasone, on fathead minnow reproduction, growth, and development. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 2012; 31:611-22. [PMID: 22189798 DOI: 10.1002/etc.1729] [Citation(s) in RCA: 79] [Impact Index Per Article: 6.1] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 08/25/2011] [Revised: 10/17/2011] [Accepted: 10/20/2011] [Indexed: 05/07/2023]
Abstract
Synthetic glucocorticoids are pharmaceutical compounds prescribed in human and veterinary medicine as anti-inflammatory agents and have the potential to contaminate natural watersheds via inputs from wastewater treatment facilities and confined animal-feeding operations. Despite this, few studies have examined the effects of this class of chemicals on aquatic vertebrates. To generate data to assess potential risk to the aquatic environment, we used fathead minnow 21-d reproduction and 29-d embryo-larvae assays to determine reproductive toxicity and early-life-stage effects of dexamethasone. Exposure to 500 µg dexamethasone/L in the 21-d test caused reductions in fathead minnow fecundity and female plasma estradiol concentrations and increased the occurrence of abnormally hatched fry. Female fish exposed to 500 µg dexamethasone/L also displayed a significant increase in plasma vitellogenin protein levels, possibly because of decreased spawning. A decrease in vitellogenin messenger ribonucleic acid (mRNA) expression in liver tissue from females exposed to the high dexamethasone concentration lends support to this hypothesis. Histological results indicate that a 29-d embryo-larval exposure to 500 µg dexamethasone/L caused a significant increase in deformed gill opercula. Fry exposed to 500 µg dexamethasone/L for 29 d also exhibited a significant reduction in weight and length compared with control fry. Taken together, these results indicate that nonlethal concentrations of a model glucocorticoid receptor agonist can impair fish reproduction, growth, and development.
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Affiliation(s)
- Carlie A LaLone
- Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, U.S. Environmental Protection Agency, Duluth, Minnesota, USA.
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