• Cardiomyocyte
• Contractility
• Costamere
• Mechanosensation
• Sarcomeres

• Vinculin/metabolism
• Vinculin/genetics
• Humans
• Haploinsufficiency
• Myocytes, Cardiac/metabolism
• Integrins/metabolism
• Integrins/genetics
• Extracellular Matrix/metabolism
• Costameres/metabolism
• Costameres/genetics
• Sarcomeres/metabolism
• Cellular Microenvironment/genetics
• Mechanotransduction, Cellular/genetics
• Myocardial Contraction/genetics

• F31 HL163996 NHLBI NIH HHS
• T32 GM008666 NIGMS NIH HHS
• F32 HL176176 NHLBI NIH HHS
• R01 AG045428 NIA NIH HHS
• R01 HL132141 NHLBI NIH HHS
• T32 GM007388 NIGMS NIH HHS
• T32 HL007444 NHLBI NIH HHS

• Cancer care
• Causal inference
• Health self-efficacy
• Patient portal

• Humans
• Patient Portals
• Neoplasms/therapy
• Self Efficacy
• Male
• Female
• Patient Satisfaction
• Middle Aged
• Adult
• Self Care
• Aged
• Cancer Survivors/psychology

• chronic disease
• disability
• joint model
• personalized risk
• self-rated health

• Aged
• Aged, 80 and over
• Female
• Humans
• Male
• Activities of Daily Living
• Chronic Disease
• Diagnostic Self Evaluation
• Disabled Persons
• Ethnicity
• Health Status
• Longitudinal Studies
• Medicare/statistics & numerical data
• Mortality/ethnology
• Mortality/trends
• Self Report
• United States
• Racial Groups

• R01 AG047891 NIA NIH HHS
• P30 AG066508 NIA NIH HHS
• P30 AG021342 NIA NIH HHS
• RF1 AG058545 NIA NIH HHS
• R01 AG055681 NIA NIH HHS

• CAR-T cell therapy
• cardiotoxicity
• chemotherapy
• immune checkpoint inhibitor
• radiotherapy
• statin
• targeted therapy

• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
• Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology
• Cardiovascular Diseases/prevention & control
• Cardiovascular Diseases/drug therapy
• Animals
• Neoplasms/drug therapy
• Antineoplastic Agents/adverse effects
• Antineoplastic Agents/therapeutic use
• Cardiotoxicity/prevention & control
• Cardiotoxicity/etiology

• 82070409 National Natural Science Foundation of China
• 82370428 National Natural Science Foundation of China
• 2021M702833 China Postdoctoral Science Foundation

• RCT study
• chronic obstructive pulmonary disease
• clinical trial
• quality of life
• traditional Chinese medicine

• BKMR Analysis
• Dyslipidemia
• Heavy Metals
• Refinery Plant

• Humans
• Cadmium
• Nickel
• Bayes Theorem
• Metals, Heavy
• Zinc
• Iron
• Republic of Korea
• Dyslipidemias
• Mercury

• 2008-07-957 Seocheon County and the National Institute of Environmental Research

• COPD
• CiteSpace
• VOSviewer
• bibliometric analysis
• lung cancer

• Humans
• Lung Neoplasms/epidemiology
• Pulmonary Disease, Chronic Obstructive/diagnosis
• Pulmonary Disease, Chronic Obstructive/epidemiology
• Pulmonary Disease, Chronic Obstructive/therapy
• Comorbidity
• Bibliometrics
• Pulmonary Fibrosis

• National Natural Science Foundation of China Project: Research on the Repair Mechanism of Respiratory Injury in COPD Mice by Traditional Chinese Medicine for Strengthening the Body, Strengthening the Health, and Regulating the Skin and Hair of the Lung (82074367); National Natural Science Foundation Project: Effect of Bufei Granule on Improving the Condition of Airway Inflammation-Mucous Hyperplasia in COPD by Controlling miRNA-TLR4 Signaling Network (81703858)

• Humans
• Pulmonary Disease, Chronic Obstructive/diagnosis
• Pulmonary Disease, Chronic Obstructive/drug therapy
• Lung
• Pulmonary Emphysema
• Risk Factors
• COVID-19/complications
• COVID-19 Testing

• Epidemiology
• MODWT
• Neural networks
• Time series forecasting
• Wavelet methods

• Humans
• Epidemics
• Neural Networks, Computer
• Public Health
• Machine Learning
• Forecasting

• Sub-Saharan Africa
• Uganda
• adverse drug reaction
• hospital admission
• low- and middle-income countries

• MR/V03510X/1 Medical Research Council
• Training Health Researchers into Vocational Excellence (THRiVE) in East Africa

• Cancer treatment
• DNMT inhibitors
• Demethylation
• Hypertrophy
• NRF2

• anticancer drugs
• cancer treatments
• cardiotoxicity
• cardiovascular events
• non-small cell lung cancer (NSCLC)

• disability
• life expectancy
• obesity
• policy
• population health

• Child
• Humans
• Obesity/epidemiology
• Schools
• Policy
• Population Health
• Health Policy

• R01 AG074019 NIA NIH HHS
• R01 AG075208 NIA NIH HHS
• R01 DK115937 NIDDK NIH HHS
• P30 AG024832 NIA NIH HHS

• Cognitive functioning
• Epidemiology
• Mushroom intake
• National Health and Nutrition Examination Survey

• death
• death certificate
• dying
• hospital
• location of death
• place of death

• COPD
• Prediction model
• anxiety
• depression
• validation

• Inflammation
• Lung
• RAGE
• Tobacco

Prediction of drug–drug interactions (DDIs) can reveal potential adverse pharmacological reactions between drugs in co-medication. Various methods have been proposed to address this issue. Most of them focus on the traditional link prediction between drugs, however, they ignore the cold-start scenario, which requires the prediction between known drugs having approved DDIs and new drugs having no DDI. Moreover, they're restricted to infer whether DDIs occur, but are not able to deduce diverse DDI types, which are important in clinics.

In this paper, we propose a cold start prediction model for both single-type and multiple-type drug–drug interactions, referred to as CSMDDI. CSMDDI predict not only whether two drugs trigger pharmacological reactions but also what reaction types they induce in the cold start scenario. We implement several embedding methods in CSMDDI, including SVD, GAE, TransE, RESCAL and compare it with the state-of-the-art multi-type DDI prediction method DeepDDI and DDIMDL to verify the performance. The comparison shows that CSMDDI achieves a good performance of DDI prediction in the case of both the occurrence prediction and the multi-type reaction prediction in cold start scenario.

Our approach is able to predict not only conventional binary DDIs but also what reaction types they induce in the cold start scenario. More importantly, it learns a mapping function who can bridge the drugs attributes to their network embeddings to predict DDIs. The main contribution of CSMDDI contains the development of a generalized framework to predict the single-type and multi-type of DDIs in the cold start scenario, as well as the implementations of several embedding models for both single-type and multi-type of DDIs. The dataset and source code can be accessed at https://github.com/itsosy/csmddi.

The online version contains supplementary material available at 10.1186/s12859-022-04610-4.

• Cold start
• Drug–drug interactions
• Machine learning
• Multi-type interactions
• Prediction

• Cardiovascular Diseases/complications
• Comorbidity
• Humans
• Lung
• Pulmonary Disease, Chronic Obstructive/complications

Rationale: Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) have been identified as independent risk factors for cardiovascular diseases. However, the impact of COPD and OSA overlap syndrome (OS) on cardiovascular outcomes remains to be elucidated.

Objective: To determine the prevalence of cardiovascular events and their risk factors in OS patients.

Methods: Seventy-four patients who had OS between January 2015 and July 2020 were retrospectively enrolled, and 222 COPD-only patients and 222 OSA-only patients were pair-matched for age and sex from the same period and served as the OS-free control group. The prevalence rates of coronary heart disease (CHD), arrhythmia, heart failure, and pulmonary arterial hypertension (PAH) were compared among the three groups, and multivariable logistic regression models were used to screen the risk factors for specific cardiovascular events.

Results: OS patients had higher prevalence rates of heart failure (10.8 vs. 0.5 and 1.4%, respectively) and PAH (31.1 vs. 4.5 and 17.1%, respectively) than those with OSA alone or COPD alone (all P < 0.01). The CHD prevalence was also significantly higher in the OS group than in the COPD-alone group (25.7 vs. 11.7%, P < 0.01). There was no significant difference in the prevalence of arrhythmia among the three groups (20.3, 22.5, and 13.1%, respectively, P > 0.05). In OS patients, risk factors for CHD included hypertension, diabetes, body mass index, lactate dehydrogenase level, and tidal volume; risk factors for heart failure included diabetes, partial pressure of oxygen, partial pressure of carbon dioxide, maximum ventilatory volume, and neutrophilic granulocyte percentage; and risk factors for PAH included minimum nocturnal oxygen saturation, partial pressure of carbon dioxide, and brain natriuretic peptide and lactate dehydrogenase levels.

Conclusions: OS patients have a higher prevalence of cardiovascular events, which is associated with hypoxemia, hypercapnia, and impaired lung function in these patients.

• cardiac rhythm abnormalities
• cardiovascular events
• chronic obstructive pulmonary disease
• obstructive sleep apnea
• overlap syndrome
• risk stratification

MicroRNAs (miRNAs) belong to the subgroup of small noncoding RNAs, which typically serve as important gene regulators to participate in different biological events, such as tumor cell growth and apoptosis. Recent studies indicated microRNA-4651 (miR-4651) was involved in hepatocellular carcinoma (HCC) progression. The certain role of miRNA-4651 during the progression of HCC, however, remains unclear. Herein, we investigated the mRNA expression level of miR-4651 in HCC tissues and HCC cell lines and found miR-4651 was noticeably down-regulated compared with the normal liver tissues and QSG-7701 cell line, respectively. Then, miR-4561 overexpression obviously repressed the proliferation and promoted apoptosis in two HCC cell lines. Interestingly, we further identified that miR-4561 could directly interact with FOXP4 in HCC cells by using bio-informatic method and report assay. Moreover, forced expression of FOXP4 showed an opposite effect compared with miR-4561 in HCC cell lines. Hence, our findings strongly indicated that miR-4561 regulated the HCC cell growth and apoptosis mainly through targeting the FOXP4 genes. Clinically, the miR-4561/FOXP4 axis might be a potential target for therapeutic application of HCC patient treatment.

• FOXP4
• apoptosis
• hepatocellular carcinoma
• miR-4651
• proliferation

• delirium
• geriatrics
• mortality
• sex differences
• trends

• Body fat distribution
• Coronary artery disease
• Multidetector computed tomography
• Obesity, abdominal

• Body Fat Distribution
• Coronary Artery Disease/diagnostic imaging
• Coronary Artery Disease/epidemiology
• Female
• Humans
• Male
• Republic of Korea/epidemiology
• Retrospective Studies

• CAD (Coronary artery disease)
• PAT (pericardial adipose tissue)
• bioinformation
• inflammation
• macrophage cell

• Adipose Tissue/metabolism
• Adipose Tissue/pathology
• Aged
• Case-Control Studies
• Coronary Artery Disease/etiology
• Coronary Artery Disease/genetics
• Coronary Artery Disease/metabolism
• Coronary Artery Disease/surgery
• Female
• Gene Expression Profiling
• Humans
• Male
• MicroRNAs/genetics
• MicroRNAs/metabolism
• Middle Aged
• Pericardium/metabolism
• Pericardium/pathology
• RNA, Messenger/genetics
• RNA, Messenger/metabolism
• RNA-Seq
• Risk Factors
• Transcriptome

Chronic obstructive pulmonary disease (COPD) is the third cause of disease-related death and brings a heavy burden to human health. Long non-coding RNA (lncRNA) was revealed to participate in COPD pathogenesis. This study aims to establish the effects and regulatory mechanism of lncRNA long intergenic non-coding 00987 (LINC00987) in lipopolysaccharide (LPS)-induced apoptosis, oxidative stress, inflammation and autophagy in BEAS-2B cells.

The expression levels of LINC00987 and let-7b-5p were detected by real-time quantitativepolymerase chain reaction (RT-qPCR). The expression of apoptosis-associated proteins, oxidative stress (ROS)-related proteins, autophagy-related proteins and sirtuin1 (SIRT1) protein was determined by Western blot. Cell viability was illustrated by cell counting kit-8 (CCK-8) assay. Cell apoptosis was investigated by caspase3 activity and apoptosis analysis assays. ROS, inflammation and autophagy were demonstrated by detecting reactive ROS level and superoxide dismutase (SOD) activity, enzyme-linked immunosorbent assay (ELISA) and Western blot analysis, respectively. The binding sites between let-7b-5p and LINC00987 or SIRT1 were predicted by lncBase or miRWalk online database, and identified by dual-luciferase reporter assay.

LINC00987 expression was strikingly downregulated and let-7b-5p expression was obviously upregulated in COPD tissues and LPS-induced BEAS-2B cells compared with control groups. LINC00987 overexpression promoted BEAS-2B cells against LPS-mediated viability, apoptosis, oxidative stress, inflammation and autophagy, whereas these effects were attenuated by let-7b-5p mimic or SIRT1 knockdown. Furthermore, LINC00987 sponged let-7b-5p and let-7b-5p bound to SIRT1.

LINC00987 ameliorated COPD through modulating LPS-induced cell apoptosis, oxidative stress, inflammation and autophagy via sponging let-7b-5p to associate with SIRT1. This finding will provide a theoretical basis for the research of LncRNA-mediated treatment in COPD.

• COPD
• LINC00987
• LPS
• SIRT1
• let-7b-5p

• artery
• atherosclerosis
• endovascular procedure
• lower extremity
• stent
• tibial
• tibioperoneal angioplasty

• Adjuvant
• Anthracycline
• Anthracycline-based chemotherapy
• Breast cancer
• Cardiotoxicity
• Early breast cancer
• Survivorship

• Chronic obstructive pulmonary disease
• arrhythmia
• comorbidity
• hypertension
• obstructive sleep apnea
• overlap syndrome

• Caregivers
• Health expenditures
• Pulmonary disease, chronic obstructive
• Quality of life

• Cost of Illness
• Cross-Sectional Studies
• Humans
• Pulmonary Disease, Chronic Obstructive/diagnosis
• Pulmonary Disease, Chronic Obstructive/therapy
• Quality of Life
• Severity of Illness Index
• Surveys and Questionnaires

• Adjunctive effects
• COPD
• COPD, Chronic Obstructive Pulmonary Disease
• Combination therapy
• FEV1, forced expiratory volume/second
• FVC, forced vital capacity
• Furosemide
• Salbutamol
• mMRC, modified Medical Research Council

As one of the leading causes of cancer-related death in the world, hepatocellular carcinoma (HCC) has continued to attract growing attention in recent decades. The use of traditional Chinese herbs in medicine has been practiced for thousands of years, and holds the potential of being a possible treatment for HCC. Curcumin, a bioactive ingredient derived from Curcuma longa, exhibits anti-tumor activity in various cancers. Although the effects of Curcumin on HCC have been elucidated, the underlying mechanism remains unclear. In the present study, Curcumin was demonstrated to inhibit the proliferation of HCC cells via inducing cell cycle arrest and apoptosis. Several previously reported lncRNAs related to tumorigenesis were chosen for examination of their expression profiles, and lincROR was found to be the most down-regulated in the Curcumin-treated HCC cells. Furthermore, Curcumin was found to decrease β-catenin expression and induce the inactivation of Wnt/β-catenin signaling. Therefore, Curcumin suppressed tumor growth through a lincROR/β-catenin regulatory pattern. In conclusion, our results demonstrated that Curcumin suppressed the cell proliferation via the down-regulation of lincROR and inactivation of Wnt/β-catenin signaling, suggesting that it may be a potential anti-cancer candidate for HCC patients with activated Wnt/β-catenin signaling.

• Wnt/β-catenin signaling
• apoptosis
• curcumin
• hepatocellular carcinoma
• lincROR

• chronic obstructive pulmonary disease
• cognitive function
• elderly people
• exercise training
• influencing factors

• Body mass index
• Chronic obstructive pulmonary disease
• Chronic obstructive pulmonary disease assessment test scores
• Depression
• Forced expiratory volume in 1 second
• Risk factors

Intracranial artery calcification can be detected on nonenhanced brain computer tomography (NECT) and is a predictor of early vascular events. Here, we assessed the impact of vertebrobasilar artery calcification (VBC) on the long-term risk for recurrent stroke and vascular events. We performed a case-control trial of all consecutive stroke patients admitted to the University Hospital of Maribor, Slovenia over a period of 14 months. VBC was defined as presence of a hyperdense area within vertebrobasilar arteries that exceeds > 90 Hounsfield units as seen on NECT. Clinical follow-up information was obtained from the hospital documentation system and mortality registry of the district and included recurrent stroke, subsequent vascular events (myocardial infarction, heart failure, peripheral arterial occlusive disease), and death. We followed a total of 448 patients for a median of 1505 days (interquartile range, IQR 188-2479). Evidence for VBC was present in 243 (54.2%) patients. Median age was 76 years, recurrent stroke occurred in 33 (7.4%), any vascular events in 71 (15.8%), and death in 276 (61.6%). VBC was associated with a higher risk of recurrent stroke (hazard ratio, HR 3.13, 95% confidence interval (CI 1.35–7.20)) and vascular events (HR 2.05, 95% CI 1.21–3.47). Advanced age, male gender, and ischemic stroke involving the entire anterior circulation raised the likelihood for death. We conclude that the presence of VBC in patients with ischemic stroke is a short- and long-term prognostic factor for stroke recurrence and subsequent manifestation of acute vascular disease. Further understanding of the pathophysiology of VBC is warranted.

• atherosclerosis
• intracerebral artery calcification
• ischemic stroke
• mortality
• prognosis
• vascular disease

• Aged
• Brain Ischemia
• Calcinosis
• Case-Control Studies
• Cerebral Infarction
• Humans
• Male
• Recurrence
• Risk Factors
• Slovenia
• Stroke/diagnosis

• cardiovascular disease
• drug-related mortality
• life expectancy
• mortality
• opioid epidemic

• ADT, androgen deprivation therapy
• ASCVD, atherosclerotic cardiovascular disease
• CI, confidence interval
• DSMB, Data Safety Monitoring Board
• GnRH, gonadotropin-releasing hormone
• MACE, major adverse cardiovascular event
• cardiovascular safety
• outcomes
• prostate cancer

• Early onset
• Rectal cancer
• Surgical Outcomes

• Chronic obstructive pulmonary disease
• Exacerbation
• Exercise training
• Long-term treatment
• Nasal high-flow therapy

• Cannula
• Disease Progression
• Duration of Therapy
• Evidence-Based Practice
• Exercise Therapy/methods
• Humans
• Hypercapnia/therapy
• Hypoxia/therapy
• Noninvasive Ventilation/methods
• Oxygen Inhalation Therapy/instrumentation
• Oxygen Inhalation Therapy/methods
• Pulmonary Disease, Chronic Obstructive/therapy
• Respiratory Insufficiency/therapy

Taxol (TAX) is a typical anticancer drug that is widely used in clinical treatment of cancer, while gold nanorods (AuNRs) are a kind of well-known material applied for photothermal therapy (PTT). The therapeutic outcome of TAX in chemotherapy is however limited by drug resistance, while AuNRs often show poor accuracy in PTT. To optimize the functions of TAX and AuNRs, we developed a hydrogen peroxide (H₂O₂)-triggered nanomaterial (LV–TAX/Au@Ag) for combined chemo-photothermal therapy. In normal tissues, TAX is protected in the lipid bilayer and isolated from the surrounding normal cells, while AuNRs are coated with silver shells and show low photothermal capacity. However, after reaching the tumor tissues, the silver shells can be etched by endogenous H₂O₂ in the tumor microenvironment, and the photothermal properties of AuNRs are then recovered. Meanwhile, the generated oxygen destabilizes the LV, which makes the 100 nm sized nanosystems disassemble into the smaller sized TAX and AuNRs, leading to the deep penetration and direct interaction with tumor tissues. The related in vitro experiments proved the validity of this “turn off/on” effect. Extensive necrosis and apoptosis were observed in the tumor tissues and the proliferation of solid tumor was greatly suppressed due to this combined chemo-photothermal therapy. In addition, no significant damage was found in normal tissues after the treatment of LV–TAX/Au@Ag. Therefore, the strategy to achieve environmental response by modifying the photothermal agents enhanced the efficiency and safety of nanomedicine, which may help improve cancer treatment.

Endogenous hydrogen peroxide was utilized to control the release of agents for better tumor therapeutic effect and safety.