Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Pharmacol. Dec 22, 2023; 12(4): 35-52
Published online Dec 22, 2023. doi: 10.5497/wjp.v12.i4.35
Natural isothiocyanates of the genus Capparis as potential agonists of apoptosis and antitumor drugs
Lumír Hanuš, Tuvia Naor, Tatyana Gloriozova, Valery M Dembitsky
Lumír Hanuš, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel
Tuvia Naor, Food Chemistry, Kibbutz, Yotvata 8882000, Israel
Tatyana Gloriozova, Department of Bioinformatics, Institute of Biomedical Chemistry, Moscow 119121, Russia
Valery M Dembitsky, Centre for Applied Research and Innovation, Lethbridge College, Lethbridge AB T1K 1L6, Canada
Co-corresponding authors: Lumír Hanuš and Valery M Dembitsky.
Author contributions: Hanuš L carried out the extraction and analysis of volatile components of yellow and green fruits, seeds, and jam from the scrambling shrub Capparis cartilaginea; Naor T grew the material and provided it for analysis; Gloriozova T determined the biological activity of volatile components; Dembitsky VM prepared the article for publication and also wrote and reviewed this article; and all authors read and approved the final version of the manuscript. In addition, the co-corresponding authors contributed equally to the accompanying manuscript, such as describing the methods, their application to the analysis, and writing the discussion.
Institutional review board statement: The study was conducted in silico and did not include humans or animals, so a statement from the Institutional Review Board was not necessary.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The study was conducted only in a computational environment and the data and three-dimensional structures used are available in public online databases.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lumír Hanuš, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel. lumirh@ekmd.huji.ac.il
Received: August 28, 2023
Peer-review started: August 28, 2023
First decision: September 19, 2023
Revised: October 12, 2023
Accepted: November 24, 2023
Article in press: November 24, 2023
Published online: December 22, 2023
Processing time: 110 Days and 16.7 Hours
Core Tip

Core Tip: Using gas chromatography-mass spectrometry analysis, we examined the composition of volatile components present in the yellow and green fruits, seeds, and jam of the scrambling shrub Capparis cartilaginea. Fruits, seeds, and jams containing isothiocyanates, which exhibit antineoplastic and anticarcinogenic activities, could be suggested for cancer prevention and management. Specific isothiocyanates, with therapeutic potential in this realm, could be recommended as potent anticancer agents in practical medicine following clinical trials.