Role of IL-2/IL-2 receptor in pathogenesis of autoimmune disorders: Genetic and therapeutic aspects

doi:10.5496/wjmg.v11.i3.28

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World Journal of Medical Genetics

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World J Med Genet. Jul 20, 2023; 11(3): 28-38
Published online Jul 20, 2023. doi: 10.5496/wjmg.v11.i3.28

Table 1 Role of interleukin (IL)-2/IL-2R in pathogenesis of autoimmune diseases

Autoimmune diseases	Pathogenesis	Genetics (SNP)	Therapy
Systemic lupus erythematosus	Acute necrotizing vasculitis	IL-2 330/T (IL-2); IL-2 330/G (IL-2); rs2069763 (IL-2); rs6822844 G/T; (IL2-IL21)	Low dose IL-2, Rituximab
Rheumatoid arthritis	Inflammatory synovitis	rs791588 (IL2RA); rs2281089 (IL2RA); rs2104286 (IL2RA)	Low dose IL-2, Infliximab
Systemic sclerosis	Obliterative vasculopathy fibrosis	rs2069762A (IL-2); rs6822844T (IL2-IL21); rs6835457G (IL-2); rs907715T (IL-2); IL2-384-G (IL-2); rs11594656 (IL-2RA); rs2104286(IL-2); rs12722495 (IL-2)	Low dose IL-2, Basiliximab
Multiple sclerosis	Inflammatory demyelination	rs2104286 (IL-2); rs11594656 (IL-2RA); rs35285258 (IL-2RB)	Tregs, MDSCs, IL-2
Sjogren syndrome	Salivary and lacrimal glands dysfunction	No data	Low dose IL-2

SNP: Single nucleotide polymorphism; IL: Interleukin; MDSCs: Myeloid-derived suppressor cells.

Citation: Rafaqat S, Rafaqat S. Role of IL-2/IL-2 receptor in pathogenesis of autoimmune disorders: Genetic and therapeutic aspects. World J Med Genet 2023; 11(3): 28-38
URL: https://www.wjgnet.com/2220-3184/full/v11/i3/28.htm
DOI: https://dx.doi.org/10.5496/wjmg.v11.i3.28