Rafaqat S, Rafaqat S. Role of IL-2/IL-2 receptor in pathogenesis of autoimmune disorders: Genetic and therapeutic aspects. World J Med Genet 2023; 11(3): 28-38 [DOI: 10.5496/wjmg.v11.i3.28]
Corresponding Author of This Article
Sana Rafaqat, PhD, Research Fellow, Department of Biotechnology, Lahore College for Women University, G8VG+FR6, Jail Road, Near Wapda Flats, Jubilee Town, Lahore 54000, Pakistan. sana.rafaqat44@gmail.com
Research Domain of This Article
Genetics & Heredity
Article-Type of This Article
Opinion Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Med Genet. Jul 20, 2023; 11(3): 28-38 Published online Jul 20, 2023. doi: 10.5496/wjmg.v11.i3.28
Role of IL-2/IL-2 receptor in pathogenesis of autoimmune disorders: Genetic and therapeutic aspects
Sana Rafaqat, Saira Rafaqat
Sana Rafaqat, Department of Biotechnology (Specialized in Human Genetics), Lahore College for Women University, Lahore 54000, Pakistan
Saira Rafaqat, Department of Zoology, Lahore College for Women University, Lahore 54000, Pakistan
Author contributions: All authors contributed equally.
Conflict-of-interest statement: The authors declared no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sana Rafaqat, PhD, Research Fellow, Department of Biotechnology, Lahore College for Women University, G8VG+FR6, Jail Road, Near Wapda Flats, Jubilee Town, Lahore 54000, Pakistan. sana.rafaqat44@gmail.com
Received: April 13, 2023 Peer-review started: April 13, 2023 First decision: June 1, 2023 Revised: June 10, 2023 Accepted: June 30, 2023 Article in press: June 30, 2023 Published online: July 20, 2023 Processing time: 97 Days and 17.7 Hours
Core Tip
Core Tip: Immune dysregulation of Interleukin-2 (IL-2) may cause tissue injury and damage leads to pathogenesis of various autoimmune diseases The aim of this review paper was to examine the role of IL-2/IL-2R in various autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), multiple sclerosis (MS) and Sjogren Syndrome (SS), which are all linked to malfunctioning of IL-2/IL-2R. IL-2 gene polymorphism is involved in increasing the risk of SLE, RA, SSc, and MS but no data has been available about the genetic role of IL-2 in the pathogenesis of Sjogren syndrome. In therapeutic approaches, a low dose of IL-2 therapy is found to be safe, effective, and well-tolerated in the treatment of SLE, RA, SSc, MS, and SS patients.
