Review
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Med Genet. Feb 27, 2015; 5(1): 1-13
Published online Feb 27, 2015. doi: 10.5496/wjmg.v5.i1.1
Cell mediated gene therapy: A guide for doctors in the clinic
Moon Jong Noh, Ogden Copeland, Michael O’Mara, Kwan Hee Lee
Moon Jong Noh, Ogden Copeland, Michael O’Mara, Kwan Hee Lee, TissueGene Inc., Rockville, MD 20850, United States
Author contributions: Noh MJ wrote most of this paper and gave input on the molecular aspect of TG-C; Copeland O reviewed and wrote the Food and Drug Administration related aspects; O’Mara M wrote the manufacturing part; Lee KH selected the review papers, decided the contents of the paper.
Conflict-of-interest: All of the authors are employees of TissueGene Inc. TissueGene Inc. will pay the fees for publication and editing of this paper. TissueGene Inc. owns the patent rights to protect the commercialization of TG-C.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kwan Hee Lee, MD, PhD, Chief Medical Officer, TissueGene Inc., 9605 Medical Center Drive, #200, Rockville, MD 20850, United States. ortholee@tissuegene.com
Telephone: +1-301-9216000101 Fax: +1-301-9216011
Received: September 25, 2014
Peer-review started: September 28, 2014
First decision: November 27, 2014
Revised: January 6, 2015
Accepted: January 15, 2015
Article in press: January 19, 2015
Published online: February 27, 2015
Processing time: 139 Days and 11.2 Hours
Core Tip

Core tip: In this review article, the authors attempted to provide an up to date summary of the current knowledge regarding cell mediated gene therapy that is, we reviewed products that have finished clinical trial, are in clinical trial and at the research stage. The authors also tried to cover the challenges, future directions, and strategies to make this technology available in the clinic. This is the right time for the physicians to have knowledge of this evolving technology that already reached the bedside.