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World J Med Genet. Nov 27, 2013; 3(4): 41-54
Published online Nov 27, 2013. doi: 10.5496/wjmg.v3.i4.41
Published online Nov 27, 2013. doi: 10.5496/wjmg.v3.i4.41
An inhibitor of HIF-α subunit expression suppresses hypoxia-induced dedifferentiation of human NSCLC into cancer stem cell-like cells
Miho Akimoto, Yoshio Honma, Keizo Takenaga, Department of Life Science, Shimane University Faculty of Medicine, Izumo 693-8501, Japan
Hideko Nagasawa, Laboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University, Gifu 501-1196, Japan
Hitoshi Hori, Yoshihiro Uto, Department of Life System, Institute of Technology and Science, Graduate School, University of Tokushima, Tokushima 770-8506, Japan
Author contributions: Takenaga K conceived and designed the experiments; Akimoto M, Takenaga K performed the experiments; Akimoto M, Takenaga K, Honma Y analyzed the data; Nagasawa H, Hori H, Uto Y contributed reagents and materials; Takenaga K, Akimoto M wrote the paper.
Supported by Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology, (No. 18590280); the Foundation for the Promotion of Cancer Research in Japan; Grant-in-Aid for Japan Arteriosclerosis Research Foundation; and Shimane University “S-TAKUMI Medical Nanotechnology” Project
Correspondence to: Keizo Takenaga, PhD, Associated professor, Department of Life Science, Shimane University Faculty of Medicine, 89-1 Enya, Izumo 693-8501, Japan. biokeizo@med.shimane-u.ac.jp
Telephone: +81-853-202352 Fax: +81-853-202340
Received: June 17, 2013
Revised: August 29, 2013
Accepted: September 3, 2013
Published online: November 27, 2013
Processing time: 187 Days and 19.7 Hours
Revised: August 29, 2013
Accepted: September 3, 2013
Published online: November 27, 2013
Processing time: 187 Days and 19.7 Hours
Core Tip
Core tip: Hypoxia induces the de-differentiation of human non-small cell lung cancer cells into cancer stem cell-like cells, and TX-402, a small-molecule inhibitor of hypoxia-inducible factor (HIF)-1α and HIF-2α expression, suppresses this hypoxia-induced process and, importantly, the metastatic ability of the cells.