Mertes H, Morissens M, Mahadeb B, Maillart E, Moreau A, Clevenbergh P. Serratia marcescens and other non-AACEK GNB endocarditis: A case report and review of literature. World J Clin Infect Dis 2019; 9(3): 23-30 [DOI: 10.5495/wjcid.v9.i3.23]
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Marielle Morissens, Cardiology Department, Brugmann University Hospital, Brussels 1020, Belgium
Bhavna Mahadeb, Microbiology Department, Brugmann University Hospital, Brussels 1020, Belgium
Evelyne Maillart, Philippe Clevenbergh, Infectious Diseases Department, Brugmann University Hospital, Brussels 1020, Belgium
Anthony Moreau, Intensive Care Unit, Erasmus University Hospital, Intensive Care Unit, Brussels 1070, Belgium
Author contributions: All authors equally contributed to this paper with regards to the conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Informed consent statement: Informed consent was obtained from the patient.
Conflict-of-interest statement: The authors report no conflicts of interest.
CARE Checklist (2016) statement: The guidelines of the "CARE Checklist - 2016: Information for writing a case report" have been adopted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Received: May 23, 2019 Peer-review started: May 23, 2019 First decision: August 7, 2019 Revised: September 3, 2019 Accepted: November 26, 2019 Article in press: November 26, 2019 Published online: December 15, 2019 Processing time: 202 Days and 23.6 Hours
Core Tip
Core tip: While gram-negative bacillus (GNB) Non-Aggregatibacter aphrophilus, Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, Kingella spp. (non-AACEK) endocarditis has been associated with mainly intravenous drug use, the role of healthcare-associated contact has been highlighted in two prospective observational studies. Our aim was to review the characteristics and management of non-AACEK GNB endocarditis, especially in the case of Serratia marcescens. This bacterium has become a rare cause of endocarditis, but community acquisition still has an important role in this disease. We discuss treatment options, supporting long-term dual-antibiotic treatment as the preferred option for most patients with non-AACEK GNB endocarditis, whereas valve surgery does not seem to be necessary in all patients.
