Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Infect Dis. Feb 25, 2017; 7(1): 1-5
Published online Feb 25, 2017. doi: 10.5495/wjcid.v7.i1.1
Is it enough to eliminate hepatitis C virus to reverse the damage caused by the infection?
Patricia Pérez-Matute, José A Oteo
Patricia Pérez-Matute, José A Oteo, Infectious Diseases Department, Center for Biomedical Research of La Rioja (CIBIR)-Hospital San Pedro, 26006 Logroño, La Rioja, Spain
Author contributions: Pérez-Matute P and Oteo JA contributed to this paper.
Conflict-of-interest statement: Authors declare no conflict of interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: José A Oteo, MD, PhD, Head of the Infectious Disease Department, Center for Biomedical Research of La Rioja (CIBIR)-Hospital San Pedro, c/Piqueras, 98, 26006 Logroño, La Rioja, Spain. jaoteo@riojasalud.es
Telephone: +34-941-278871 Fax: +34-941-298667
Received: August 26, 2016
Peer-review started: August 27, 2016
First decision: October 28, 2016
Revised: November 18, 2016
Accepted: December 1, 2016
Article in press: December 2, 2016
Published online: February 25, 2017
Core Tip

Core tip: Hepatitis C infection represents one of the major causes of chronic liver disease, hepatocellular carcinoma and morbidity/mortality worldwide. A complete elimination of the hepatitis C virus (HCV) from the body through treatment is now possible. However, HCV not only alters the hepatic function. In fact, changes in gut microbiota composition (GM) and gut barrier that leads to an increased bacterial translocation and inflammation have also been observed. Thus, a successful treatment of HCV infection should be accompanied by a complete restoration of GM and inflammation. Studies focused on GM after HCV eradication are lacking, which opens unique opportunities to deeply explore this exciting field.