Systematic Reviews
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Infect Dis. Sep 18, 2020; 10(3): 33-41
Published online Sep 18, 2020. doi: 10.5495/wjcid.v10.i3.33
Antibiotics for complicated urinary tract infection and acute pyelonephritis: A systematic review
Leong Tung Ong
Leong Tung Ong, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
Author contributions: Ong LT designed the literature search, performed the search, analysed the data, wrote the paper, and approved the final manuscript.
Conflict-of-interest statement: The author declares that he has no competing interests.
PRISMA 2009 Checklist statement: The guidelines of the PRISMA 2009 statement have been adopted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Leong Tung Ong, MBBS, Faculty of Medicine, University of Malaya, Kuala Lumpur, Wilayah Persekutuan, Kuala Lumpur 50603, Malaysia.
Received: April 19, 2020
Peer-review started: April 19, 2020
First decision: July 8, 2020
Revised: July 8, 2020
Accepted: August 1, 2020
Article in press: August 1, 2020
Published online: September 18, 2020
Core Tip

Core Tip: There is an increasing resistance rate to the antibiotics recommended by current guidelines for the treatment of complicated urinary tract infection (UTI) and acute pyelonephritis. Therefore, alternative antibiotics need to be explored to increase the cure rate and improve the outcomes of patients. The aim of this systematic review is to investigate the efficacy and safety of different antibiotic therapy in treating complicated UTI and acute pyelonephritis. The use of novel antibiotics and combination antibiotic therapy can be considered in treating complicated UTI and acute pyelonephritis when resistance to recommended antibiotics occurs.