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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Infect Dis. Jun 18, 2020; 10(2): 24-32
Published online Jun 18, 2020. doi: 10.5495/wjcid.v10.i2.24
Published online Jun 18, 2020. doi: 10.5495/wjcid.v10.i2.24
Predictors of severe and critical COVID-19: A systematic review
Sameh Hany Emile, General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura City 35516, Egypt
Sualeh Muslim Khan, Dow Medical College, Dow University of Health Sciences, Karachi 74200, Pakistan
Author contributions: Emile SH designed and wrote the manuscript; Khan SM contributed to data collection and analysis and revision of the manuscript.
Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.
PRISMA 2009 Checklist statement: The manuscript has been revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Sameh Hany Emile, MD, Associate Professor, Surgeon, General Surgery Department, Mansoura University Hospitals, Mansoura University, Dakahlia Governorate, Mansoura City 35516, Egypt. dr_sameh81@mans.edu.eg
Received: April 23, 2020
Peer-review started: April 23, 2020
First decision: May 5, 2020
Revised: May 6, 2020
Accepted: May 21, 2020
Article in press: May 21, 2020
Published online: June 18, 2020
Processing time: 55 Days and 15.9 Hours
Peer-review started: April 23, 2020
First decision: May 5, 2020
Revised: May 6, 2020
Accepted: May 21, 2020
Article in press: May 21, 2020
Published online: June 18, 2020
Processing time: 55 Days and 15.9 Hours
Core Tip
Core tip: After systematic literature search, several demographic, clinical, laboratory, and radiologic factors were found to be predictive of severe and critical coronavirus disease 2019 along with the potential need for mechanical ventilation. Factors that were more commonly reported were older age, medical comorbidities, lymphopenia, increased neutrophil ratio, elevated C-reactive protein, and increased D-dimer. Findings on computed tomography (CT) scanning predictive of severe disease were bronchial wall thickening, CT score > 7, linear opacities, consolidation, right upper lobe affection, and crazy paving pattern.