Roles of catecholamine related polymorphisms in hypertension

Table 1 List of recent studies on β2-adrenergic receptor polymorphisms, blood pressure and hypertension

SNP	Ref.	Ethnicity	Sample size(HT/NT)	Association/significance	Parameter
Arg16Gly	Kotanko et al[18] 1997	African Caribbeans	136/81	Yes	Hypertension
Arg16Gly	Gratze et al[19] 1999	Austrian Caucasians	57 NT	Yes	Blood pressure regulation
Gln27Glu Arg16Gly	Candy et al[20] 2000	Black South African	192/123	No	Hypertension, blood pressure Left ventricular mass
Gln27Glu Arg16Gly	Bray et al[21] 2000	Non-hispanic whites	589 families (> 2000)	Yes	Hypertension systolic, diastolic and mean arterial pressure
Gln27Glu Arg16Gly	Jia et al[22] 2000	Caucasians	298/298	No	Hypertension
Gln27Glu Arg16Gly	Xie et al[23] 2000	Black or white Americans	356/307	No	Hypertension
Arg16Gly	Herrmann et al[24] 2000	Black or white Americans	243	No	Hypertension
T-47C Gln27Glu Arg16Gly	Kato et al[25] 2001	Japanese	842/633	No	Hypertension
T-47C Gln27Glu Arg16Gly	Ranade et al[26] 2001	Chinese	> 800/> 800	Yes (only for Arg16Gly)	Hypertension
Gln27Glu Arg16Gly Thr164Ile	Tomaszewski et al[27] 2002	European (Polish)	638	No	Hypertension
Gln27Glu Arg16Gly Thr164Ile	Pereira et al[28] 2003	Brasilian	1576	Yes	Hypertension, blood pressure
Gln27Glu Arg16Gly	Galletti et al[29] 2004	Non-selected group- middle aged men	405 HT 563 overweight	No	Hypertension, overweight
T-47C Gln27Glu Arg16Gly	Ge et al[30] 2005	Han Chinese	503/504	Yes	Hypertension

SNP: Single nucleotide polymorphism; HT: Hypertensive ; NT: Normotensive.