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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hypertens. Nov 23, 2015; 5(4): 129-136
Published online Nov 23, 2015. doi: 10.5494/wjh.v5.i4.129
Published online Nov 23, 2015. doi: 10.5494/wjh.v5.i4.129
Estimated net endogenous acid production and risk of prevalent and incident hypertension in community-dwelling older people
Ruth Chan, Jean Woo, Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Shatin, Hong Kong, China
Jason Leung, Jockey Club Centre for Osteoporosis Care and Control, the Chinese University of Hong Kong, Shatin, Hong Kong, China
Author contributions: Chan R conceptualized the study, performed data analysis and drafted the manuscript; Leung J assisted in data analysis and results interpretation and provided comments on the manuscript; Woo J provided administrative support for the study and commented on the manuscript; all authors read and approved the final manuscript.
Supported by Grants from the Research Grants Council of Hong Kong, CUHK 4101/02M; the Hong Kong Jockey Club Charities Trust; the SH Ho Centre for Gerontology and Geriatric; and the Centre for Nutritional Studies, The Chinese University of Hong Kong.
Institutional review board statement: This study was conducted in accordance with the Declaration of Helsinki. This study was approved by the Clinical Research Ethics Committee of the Chinese University of Hong Kong.
Clinical trial registration statement: Not applicable for this study.
Informed consent statement: Written informed consent was obtained from all subjects.
Conflict-of-interest statement: The authors of this manuscript have no conflicts of interest to disclose.
Data sharing statement: There is no additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ruth Chan, Research Assistant Professor, Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Rm 124021, 10/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong, China. ruthchansm@cuhk.edu.hk
Telephone: +852-26322190 Fax: +852-26379215
Received: June 8, 2015
Peer-review started: June 10, 2015
First decision: July 10, 2015
Revised: September 30, 2015
Accepted: October 23, 2015
Article in press: October 27, 2015
Published online: November 23, 2015
Processing time: 163 Days and 19.4 Hours
Peer-review started: June 10, 2015
First decision: July 10, 2015
Revised: September 30, 2015
Accepted: October 23, 2015
Article in press: October 27, 2015
Published online: November 23, 2015
Processing time: 163 Days and 19.4 Hours
Core Tip
Core tip: This prospective study investigated the associations between baseline dietary acid-base load and prevalent and 4-year incident hypertension in community-dwelling Chinese older adults in Hong Kong. Baseline dietary data were collected using a validated food frequency questionnaire (FFQ). Estimated dietary net endogenous acid production (NEAP) was calculated based on the diet’s protein to potassium ratio from the FFQ. Higher quartile of energy-adjusted estimated NEAP was associated with increased likelihood of prevalent hypertension [multivariable OR = 1.66 (95%CI: 1.22 to 2.26, Ptrend = 0.002)]. No significant association was observed between energy-adjusted estimated NEAP and risk of incident hypertension.