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©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Hypertens. Aug 23, 2013; 3(3): 18-26
Published online Aug 23, 2013. doi: 10.5494/wjh.v3.i3.18
Published online Aug 23, 2013. doi: 10.5494/wjh.v3.i3.18
Adipose tissue dysfunction and the pathogenesis of metabolic syndrome
Di Zhao, Division of Hypertension, the Second Hospital Affiliated to Zhengzhou University, Zhengzhou 450014, Henan Province, China
Hui Liu, Division of Endocrinology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang 450000, Henan Province, China
Author contributions: Zhao D prepared and wrote the review; Liu H prepared the review and approved the final version of manuscript.
Correspondence to: Di Zhao, MD, PhD, Distinguished Professor of Zhengzhou University, Division of Hypertension, the Second Hospital Affiliated to Zhengzhou University, 2 Jingba Street, Zhengzhou 450014, Henan Province, China. emaildizhao@yahoo.com
Telephone: +86-371-63974095 Fax: +86-371-63921651
Received: June 27, 2013
Revised: August 21, 2013
Accepted: August 22, 2013
Published online: August 23, 2013
Processing time: 106 Days and 2.9 Hours
Revised: August 21, 2013
Accepted: August 22, 2013
Published online: August 23, 2013
Processing time: 106 Days and 2.9 Hours
Core Tip
Core tip Metabolic syndrome is a growing research area. Insulin resistance, obesity, inflammation and oxidative stress may play an important role in the pathogenesis of metabolic syndrome. The role of adipose tissue dysfunction is emphasized during the development of obesity in recent years. The study around adipose tissue dysfunction will help to understand the pathogenesis of metabolic syndrome and may bring effective therapy in treatment of metabolic syndrome related diseases. Therefore, this review mainly focuses on the roles of adipose tissue dysfunction in inflammation, insulin resistance, and oxidative stress in the pathogenesis of metabolic syndrome.