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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hypertens. May 23, 2016; 6(2): 66-75
Published online May 23, 2016. doi: 10.5494/wjh.v6.i2.66
Published online May 23, 2016. doi: 10.5494/wjh.v6.i2.66
Role of adipocytes in hypertension
Rebecca Martin, Joseph I Shapiro, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, United States
Author contributions: Both authors contributed to this paper.
Conflict-of-interest statement: Neither Dr. Shapiro or Ms. Martin has conflicts of interest to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Joseph I Shapiro, MD, Dean, Professor of Medicine, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Suite 3408, Huntington, WV 25701, United States. shapiroj@marshall.edu
Telephone: +1-304-6911700 Fax: +1-304-6911726
Received: March 3, 2016
Peer-review started: March 4, 2016
First decision: April 15, 2016
Revised: May 12, 2016
Accepted: May 20, 2016
Article in press: May 21, 2016
Published online: May 23, 2016
Processing time: 101 Days and 11.8 Hours
Peer-review started: March 4, 2016
First decision: April 15, 2016
Revised: May 12, 2016
Accepted: May 20, 2016
Article in press: May 21, 2016
Published online: May 23, 2016
Processing time: 101 Days and 11.8 Hours
Abstract
Although it has known for some time that obesity is associated with salt sensitivity and hypertension, recent data suggests that the adipocyte may actually be the proximate cause of this physiological changes. In the following review, the data demonstrating this association as well as the potentially operative pathophysiological mechanisms are reviewed and discussed.
Keywords: Hypertension; Oxidant stress; Natriuresis; Heme oxygenase; Nitric oxide; Renal function; Obesity
Core tip: Hypertension is a growing problem worldwide, and the problem is exacerbated by the growing obesity epidemic. This review looks into the complex relationship between these two diseases, outlining what current literature reports for treatment methods, hypotheses on cause, and potential cross talk between the two.