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World J Hypertens. May 23, 2015; 5(2): 93-97
Published online May 23, 2015. doi: 10.5494/wjh.v5.i2.93
Clinical implication of hematological indices in the essential hypertension
Ahmet Karabulut, Aytac Karadag
Ahmet Karabulut, Department of Cardiology, Acibadem University School of Medicine, Acibadem Atakent Hospital, Istanbul 34303, Turkey
Aytac Karadag, Department of Internal Medicine, Acibadem Atakent Hospital, Istanbul 34303, Turkey
Author contributions: Karabulut A performed the majority of the work in the term of design, writing and submission; Karadag A provided literature review and final evaluation of the article before submission.
Conflict-of-interest: The authors did not report conflict of interest regarding this work. This work was not supported by any company.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ahmet Karabulut, MD, Associate Professor, Department of Cardiology, Acibadem Atakent Hospital, Turgut Ozal Bulvari No. 16, Istanbul 34303, Turkey. drkarabulut@yahoo.com
Telephone: +90-505-3577477 Fax: +90-212-4044445
Received: September 27, 2014
Peer-review started: September 28, 2014
First decision: January 20, 2015
Revised: March 10, 2015
Accepted: April 16, 2015
Article in press: April 18, 2015
Published online: May 23, 2015
Processing time: 235 Days and 23 Hours
Abstract

Prognostic value of haematological indices, especially red cell distribution width, neutrophil lymphocyte ratio and mean platelet volume, was reported with numerous investigations in miscellaneous cardiovascular settings. Their major prognostic value was linked to oxidative stress and inflammation since their level was correlated with major inflammatory markers such as high sensitive C-reactive protein and interleukins. Oxidative stress and chronic inflammation are also postulated as the main pathophysiologic mechanism of essential hypertension (HT) and its vascular complication. Recently, correlation between HT and haematological parameters was searched in numerous studies, which has made the topic more popular. Herein, we reveal the correlation between haematological indices and HT and we also demonstrate the clinical implication of this correlation. Impaired haematological parameters may strongly indicate hypertensive end-organ damage.

Keywords: Hypertension; Inflammation; End-organ damage; Haematological indice; Platelet activation

Core tip: We demonstrated the correlation between haematological indices, particularly red cell distribution width, neutrophil lymphocyte ratio and mean platelet volume, and hypertension and we also clarified the clinical implication of the haematological markers in hypertensive end-organ failure. Impaired haematological parameters may strongly indicate the hypertensive end-organ damage.