Copyright
©The Author(s) 2025.
World J Exp Med. Jun 20, 2025; 15(2): 100443
Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.100443
Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.100443
Table 1 Short tandem repeat analysis
Microsatellite (chromosome number) | OCUG-2 cells |
D3S1358 (3) | 16 |
TH01 (11) | 7, 9 |
D21S11 (21) | 30 |
D18S51 (18) | 13 |
Penta E (15) | 12 |
D5S818 (5) | 12 |
D13S317 (13) | 12 |
D7S820 (7) | 9, 12 |
D16S539 (16) | 9, 10 |
CSF1PO (5) | 12 |
Penta D (21) | 11 |
Amelogenin (X Y) | X |
vWA (12) | 16 |
D8S1179 (8) | 13, 15 |
TPOX (2) | 8, 12 |
FGA (4) | 20, 21 |
Table 2 Correlation between clinicopathologic features and insulin-like growth factor 1 receptor expression in gallbladder cancer
Feature | IGF1R-positive (n = 17) | IGF1R-negative (n = 17) | P value |
Sex | |||
Male | 6 | 10 | |
Female | 11 | 7 | 0.17 |
Chemotherapy | |||
Yes | 11 | 10 | |
No | 6 | 7 | 0.72 |
T stage | |||
T1/T2 | 8 | 10 | |
T3/T4 | 9 | 7 | 0.49 |
N stage | |||
Negative | 8 | 12 | |
Positive | 9 | 5 | 0.16 |
M stage | |||
Negative | 14 | 16 | |
Positive | 3 | 1 | 0.28 |
Clinical stage | |||
I/II | 6 | 10 | |
III/IV | 11 | 7 | 0.16 |
Table 3 Univariate and multivariate regression analyses of overall survival
Feature | Univariate analysis | Multivariate analysis | ||
Hazard ratio (95%CI) | P value | Hazard ratio (95%CI) | P value | |
Sex | 0.658 (0.259-1.672) | NS | ||
Chemotherapy | 3.039 (1.077-8.578) | 0.03 | 1.969 (0.594-6.517) | NS |
T | 1.771 (1.165-2.692) | 0.005 | ||
N | 2.833 (1.2-6.687) | 0.01 | ||
M | 4.905 (1.516-15.88) | 0.003 | ||
Stage | 1.767 (1.146-2.723) | 0.006 | 1.595 (0.950-2.679) | 0.077 |
IGF1R expression | 2.654 (1.102-6.913) | 0.04 | 3.302 (1.208-9.023) | 0.02 |
Table 4 Candidate gene fusions detected in RNA sequencing data of OCUG-2 cells
Gene fusion | Breakpoint1 | Breakpoint2 | Confidence | Reading frame |
LEPROT: LEPR | chr1:65425378 | chr1:65565546 | High | Out-of-frame |
LEPROT: LEPR | chr1:65430048 | chr1:65565546 | Medium | Out-of-frame |
TSPAN14: AL392185.1 | chr10:80504778 | chr9:95602159 | High | Out-of-frame |
TSPAN14: AL392185.1 | chr10:80489314 | chr9:95602159 | High | Out-of-frame |
TSPAN14: AL392185.1 | chr10:80506862 | chr9:95602874 | Medium | |
TSPAN14: AL392185.1 | chr10:80504778 | chr9:95600165 | Medium | Out-of-frame |
RNF115: ITGA10 | chr1:145823772 | chr1:145907465 | High | Out-of-frame |
PCDHA3: PCDHAC2 | chr5:140803591 | chr5:140978949 | High | In-frame |
AC092807.3: DDAH1 | chr1:85496166 | chr1:85358847 | High | |
AC092807.3: DDAH1 | chr1:85494729 | chr1:85358847 | Medium | |
AC092807.3: DDAH1 | chr1:85577984 | chr1:85358847 | Medium | |
ERC1: PDE3A | chr12:1141787 | chr12:20556660 | High | In-frame |
TVP23C: CDRT4 | chr17:15540433 | chr17:15440285 | High | Out-of-frame |
PRR16: AC114284.1 | chr5:120464645 | chr5:120789954 | High | Out-of-frame |
PCDHGB2: PCDHGA8 | chr5:141362556 | chr5:141494807 | Medium | In-frame |
MYO9A: PKM | chr15:72117680 | chr15:72219110 | Medium | |
RASSF8: SSPN | chr12:26055446 | chr12:26224293 | Medium | Out-of-frame |
RASSF8: SSPN | chr12:26055446 | chr12:26179996 | Medium | Out-of-frame |
AC104123.1: CAST | chr5:96379652 | chr5:96675539 | Medium | |
MGST1: AC007529.2 | chr12:16383604 | chr12:16661766 | Medium | |
LDLRAD3: PRR5L | chr11:36098461 | chr11:36296290 | Medium | Out-of-frame |
- Citation: Wang Q, Fan C, Tsujio G, Sakuma T, Maruo K, Yamamoto Y, Imanishi D, Kawabata K, Nishikubo H, Kanei S, Aoyama R, Kushiyama S, Ohira M, Yashiro M. Establishment and characterization of a new human gallbladder cancer cell line, OCUG-2. World J Exp Med 2025; 15(2): 100443
- URL: https://www.wjgnet.com/2220-315x/full/v15/i2/100443.htm
- DOI: https://dx.doi.org/10.5493/wjem.v15.i2.100443