Review
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Aug 20, 2015; 5(3): 164-181
Published online Aug 20, 2015. doi: 10.5493/wjem.v5.i3.164
Use of siRNA molecular beacons to detect and attenuate mycobacterial infection in macrophages
Remo George, Renata Cavalcante, Celso Carvalho Jr, Elyana Marques, Jonathan B Waugh, M Tino Unlap
Remo George, Renata Cavalcante, Celso Carvalho Jr, Elyana Marques, Jonathan B Waugh, M Tino Unlap, Center for Teaching and Learning and the Department of Clinical and Diagnostic Sciences, University of Alabama at Birmingham, Birmingham, AL 35294-1212, United States
Author contributions: George R, Cavalcante R, Carvalho Jr C, Marques E, Waugh JB and Unlap MT equally contributed to this work; George R, Waugh JB and Unlap MT designed the research; George R, Cavalcante R, Carvalho Jr C, Marques E and Unlap MT performed the research; Waugh JB and Unlap MT analyzed the data; George R, Waugh JB and Unlap MT wrote the paper.
Conflict-of-interest statement: The authors have no conflict of interest to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jonathan B Waugh, PhD, Professor and Director, Department of Clinical and Diagnostic Sciences, University of Alabama at Birmingham, 1705 University Blvd., Birmingham, AL 35294-1212, United States. waughj@uab.edu
Telephone: +1-205-9758344 Fax: +1-205-9757302
Received: February 26, 2015
Peer-review started: February 26, 2015
First decision: April 27, 2015
Revised: May 21, 2015
Accepted: June 9, 2015
Article in press: June 11, 2015
Published online: August 20, 2015
Processing time: 181 Days and 3.8 Hours
Core Tip

Core tip: This review paper looks at the current status of research of the role of mammalian cell entry gene products in mediating cholesterol mediated latency of mycobacteria and the potential use of short-interfering RNA molecular beacons in detecting and attenuating mycobacterial infections.