Epigallocatechin-3-gallate suppresses transforming growth factor-beta signaling by interacting with the transforming growth factor-beta type II receptor

doi:10.5493/wjem.v3.i4.100

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World Journal of Experimental Medicine

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2220-315x

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Exp Med. Nov 20, 2013; 3(4): 100-107
Published online Nov 20, 2013. doi: 10.5493/wjem.v3.i4.100

Epigallocatechin-3-gallate suppresses transforming growth factor-beta signaling by interacting with the transforming growth factor-beta type II receptor

Masaki Tabuchi, Sumio Hayakawa, Eiko Honda, Kana Ooshima, Tatsuki Itoh, Koji Yoshida, Ah-Mee Park, Hideaki Higashino, Mamoru Isemura, Hiroshi Munakata

Masaki Tabuchi, Koji Yoshida, Ah-Mee Park, Hiroshi Munakata, Department of Biochemistry, Kinki University Faculty of Medicine, Osaka-Sayama 589-8511, Japan

Sumio Hayakawa, Division of Signaling in Cancer and Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan

Eiko Honda, Life Science Research Institute, Kinki University, Osaka-Sayama 589-8511, Japan

Kana Ooshima, Hideaki Higashino, Department of Pharmacology, Kinki University Faculty of Medicine, Osaka-Sayama 589-8511, Japan

Tatsuki Itoh, Department of Pathology, Kinki University Faculty of Medicine, Osaka-Sayama 589-8511, Japan

Mamoru Isemura, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan

Author contributions: Tabuchi M and Hayakawa S contributed equally to this work; Tabuchi M and Hayakawa S designed studies; Tabuchi M, Hayakawa S, Honda E, Ooshima K, Itoh T, Yoshida K, Park AM, Higashino H and Isemura M performed the research; Tabuchi M, Hayakawa S and Munakata H analyzed the data; Munakata H wrote the paper.

Correspondence to: Hiroshi Munakata, Professor, Department of Biochemistry, Kinki University Faculty of Medicine, 377-2 Ohnohigashi, Osaka-Sayama 589-8511, Japan. munakata@med.kindai.ac.jp

Telephone: +81-72-3660221 Fax: +81-72-3660245

Received: May 14, 2013
Revised: July 12, 2013
Accepted: September 18, 2013
Published online: November 20, 2013
Processing time: 190 Days and 7.2 Hours

Core Tip

Core tip: (-)-Epigallocatechin-3-gallate (EGCG) binds to transforming growth factor-β (TGF-β) type II receptor (TGFRII) and inhibits TGF-β action by interfering with the interaction between TGF-β and TGFRII. Because TGF-β is considered to be the strongest inducer of tissue fibrosis, the obtained data from this investigation suggest that EGCG may be a new therapeutic agent for organ fibrosis.