Clinical Trials Study
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World J Exp Med. Jun 20, 2025; 15(2): 105636
Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.105636
Evaluation of the clinical efficacy of green tea extract gel as local drug delivery for periodontitis
Santhiya Rengaraj, Sri Sivashankari Thilagar, Pradeep Kumar Yadalam, Priyanka Pampani, Ebenezer Mani, Carlos M Ardila
Santhiya Rengaraj, Department of Periodontics, The Nellai Dental Care, Tirunelveli 600077, India
Sri Sivashankari Thilagar, Pradeep Kumar Yadalam, Carlos M Ardila, Department of Periodontics, Saveetha Dental College, and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha 600077, India
Priyanka Pampani, Ebenezer Mani, Department of Periodontics, Adhiparasakthi Dental College, Melmaruvathur 600077, India
Carlos M Ardila, Basic Sciences Department, Biomedical Stomatology Research Group, Faculty of Dentistry, Universidad de Antioquia, U de A, Medellín 050010, Antioquia, Colombia
Co-corresponding authors: Pradeep Kumar Yadalam and Carlos M Ardila.
Author contributions: Rengaraj S performed the conceptualization, data curation, data analysis, manuscript writing, and revision of the manuscript; Thilagar SS performed the conceptualization, data curation, data analysis, manuscript writing, and revision of the manuscript; Yadalam PK performed the conceptualization, data curation, data analysis, manuscript writing, and revision of the manuscript; Pampani P performed the conceptualization, data curation, data analysis, manuscript writing, and revision of the manuscript; Mani E performed the conceptualization, data curation, data analysis, manuscript writing, and revision of the manuscript; Ardila CM performed the conceptualization, data curation, data analysis, manuscript writing, and revision of the manuscript. The designation of two co-corresponding authors is justified based on their equal and significant contributions to the conceptualization, execution, and communication of this study. Both authors have played pivotal roles in guiding the research, analyzing data, and ensuring the manuscript's accuracy and completeness. Additionally, their expertise complements each other. This dual designation ensures efficient communication with the scientific community and readers, as both authors are equally equipped to address inquiries related to their respective areas of expertise. It also reflects the collaborative nature of the research and acknowledges their shared responsibility in the study's success. This rationale highlights the collaborative effort and expertise of both authors, which aligns with the journal's expectations for co-corresponding authorship.
Institutional review board statement: The study was conducted at the Department of Periodontology and Implantology, Adhiparasakthi Dental College and Hospital, Melmaruvathur, following approval from the Institutional Review Board (2020-MDS-BrI1-SIV-05/APDCH).
Clinical trial registration statement: This is a Clinical Practice Study therefore it does not require registration as a clinical trial.
Informed consent statement: Written informed consent was obtained from all participants, and the study adhered to the guidelines outlined in the Declaration of Helsinki.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at martin.ardila@udea.edu.co.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Carlos M Ardila, Postdoctoral Fellow, Professor, Senior Researcher, Basic Sciences Department, Biomedical Stomatology Research Group, Faculty of Dentistry, Universidad de Antioquia, U de A, Calle 70 No. 52-21, Medellín 050010, Antioquia, Colombia. martin.ardila@udea.edu.co
Received: February 2, 2025
Revised: March 3, 2025
Accepted: March 14, 2025
Published online: June 20, 2025
Processing time: 75 Days and 7.1 Hours
Core Tip

Core Tip: Green tea extract gel, rich in epigallocatechin gallate, outperformed ornidazole gel as an adjunct to scaling and root planing in treating periodontitis, demonstrating superior reduction in probing pocket depths after one month. This study highlights green tea extract’s potential as a natural, effective alternative for localized antimicrobial therapy, offering enhanced anti-inflammatory and antimicrobial benefits for periodontal disease management. Its promising results suggest a shift toward plant-based adjuncts in periodontal care.