Therapeutic strategies and prognostic challenges in linitis plastica

doi:10.5493/wjem.v15.i1.96318

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Mar 20, 2025 (publication date) through Feb 8, 2025

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World Journal of Experimental Medicine

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2220-315x

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Exp Med. Mar 20, 2025; 15(1): 96318
Published online Mar 20, 2025. doi: 10.5493/wjem.v15.i1.96318

Therapeutic strategies and prognostic challenges in linitis plastica

Grigorios Christodoulidis, Sara Eirini Agko, Konstantinos Eleftherios Koumarelas, Marina Nektaria Kouliou

Grigorios Christodoulidis, Marina Nektaria Kouliou, Department of General Surgery, University Hospital of Larissa, Larissa 41110, Greece

Sara Eirini Agko, Intensive Care Unit, Asklepios Paulinen Clinic Wiesbaden, Wiesbaden 65197, Germany

Konstantinos Eleftherios Koumarelas, Department of Emergency Medicine, General Hospital of Larissa, Larissa 41221, Greece

Author contributions: Christodoulidis G designed the overall concept and outline of the manuscript; Christodoulidis G, Agko ES, Koumarelas KE and Kouliou MN contributed to the discussion and design of the manuscript; Christodoulidis G, Agko ES, Koumarelas KE and Kouliou MN contributed to the writing, editing the manuscript, and review of literature.

Conflict-of-interest statement: Nothing to disclose.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Grigorios Christodoulidis, MD, PhD, Surgeon, Department of General Surgery, University Hospital of Larissa, Mezourlo, Larissa 41110, Greece. gregsurg@yahoo.gr

Received: May 3, 2024
Revised: October 9, 2024
Accepted: November 29, 2024
Published online: March 20, 2025
Processing time: 236 Days and 17.3 Hours

Core Tip

Core Tip: Linitis plastica (LP) gastric cancer poses a significant challenge due to its aggressive nature and poor prognosis. Early detection and personalized treatment strategies are essential for improving outcomes in LP patients. While surgery remains the mainstay of treatment, the role of adjuvant chemotherapy and postoperative radiotherapy is still under debate. Neoadjuvant chemotherapy, particularly with regimens such as docetaxel plus oxaliplatin and S-1, shows promise in enhancing survival rates for LP patients. Multidisciplinary collaboration and further research are necessary to optimize therapeutic interventions and improve outcomes in this challenging subset of gastric cancer.