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World J Exp Med. Sep 20, 2024; 14(3): 97233
Published online Sep 20, 2024. doi: 10.5493/wjem.v14.i3.97233
Anti-aging based on stem cell therapy: A scoping review
Nassar El Assaad, Alain Chebly, Rawad Salame, Robert Achkar, Nour Bou Atme, Khalil Akouch, Paul Rafoul, Colette Hanna, Samer Abou Zeid, Marwan Ghosn, Charbel Khalil
Nassar El Assaad, Nour Bou Atme, Samer Abou Zeid, Marwan Ghosn, Faculty of Medicine, Saint Joseph University, Beirut 961, Lebanon
Alain Chebly, Centre Jacques Loiselet for Medical Genetics and Genomics (CGGM), Faculty of Medicine, Saint Joseph University, Beirut 961, Lebanon
Alain Chebly, Higher Institute of Public Health, Saint Joseph University, Beirut 961, Lebanon
Rawad Salame, Khalil Akouch, Charbel Khalil, Stem Cell Therapy Lab, Reviva Regenerative Medicine Center, Beirut 961, Lebanon
Robert Achkar, Poz Pozan University of Medical Sciences, Pozan 034, Poland
Paul Rafoul, Department of Epidemiology and Biostatistics, Faculty of Public Health, Lebanese University, Beirut 961, Lebanon
Colette Hanna, Charbel Khalil, School of Medicine, Lebanese American University, Beirut 961, Lebanon
Charbel Khalil, Bone Marrow Transplant Unit, Burjeel Medical City, Abu Dhabi 999041, United Arab Emirates
Author contributions: Khalil C was responsible for conceptualization and supervision; Ghosn M, Khalil C, Chebly A and Bou Atme N were responsible for methodology; Khalil C and Rafoul P were responsible for validation; El Assaad N and Khalil Cwere responsible for formal analysis, data curation; Khalil C and Akouch K were responsible for writing-original draft preparation; Akouch K, Achkar R, Bou Atme N and Khalil Cwere responsible for visualization; El Assaad N, Hanna C, Salame R, Ghosn M, Abou Zeid S, Achkar R, Raffoul P, Hanna C, Chebly A and Khalil C were responsible for writing - review & editing; all authors have read and agreed to the submitted version of the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Charbel Khalil, PhD, Director, Stem Cell Therapy Lab, Reviva Regenerative Medicine Center, Bsalim, Main Road Lebanon, Beirut 961, Beyrouth, Lebanon. c.khalil@revivamedical.net
Received: May 26, 2024
Revised: July 4, 2024
Accepted: July 18, 2024
Published online: September 20, 2024
Processing time: 94 Days and 20.1 Hours
Core Tip

Core Tip: Mesenchymal stem cells (MSCs) exhibit promising anti-aging properties by targeting the underlying mechanisms of aging, including chronic inflammation, cellular senescence, and oxidative stress. Through their regenerative potential, immunomodulatory abilities, and secretome production, MSCs contribute to tissue repair and rejuvenation. These unique capabilities position MSCs as key players in the future of anti-aging therapies and regenerative medicine, offering potential interventions for promoting healthier and more vibrant aging.