Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Sep 20, 2024; 14(3): 95540
Published online Sep 20, 2024. doi: 10.5493/wjem.v14.i3.95540
Platelet-to-neutrophil ratio predicts hemorrhagic transformation and unfavorable outcomes in acute ischemic stroke with intravenous thrombolysis
Ausanee Chaiwisitkun, Sombat Muengtaweepongsa
Ausanee Chaiwisitkun, Sombat Muengtaweepongsa, Center of Excellence in Stroke, Faculty of Medicine, Thammasat University, Klonglaung 12120, Pathum Thani, Thailand
Author contributions: Chaiwisitkun A and Muengtaweepongsa S were responsible for the conceptualization and design of the study; Muengtaweepongsa S was responsible for the formal analysis; Chaiwisitkun A and Muengtaweepongsa S were responsible for the investigation; Chaiwisitkun A was responsible for the original draft preparation; Muengtaweepongsa S was responsible for validation, review, and editing.
Institutional review board statement: The Human Research Ethics Committee of Thammasat University (Medicine) bestowed approval for this study and granted a waiver for the requirement of informed consent, under approval number 284/2564. All methodologies employed throughout the study adhered scrupulously to pertinent guidelines and regulations.
Informed consent statement: The Human Research Ethics Committee of Thammasat University (Medicine) bestowed approval for this study and granted a waiver for the requirement of informed consent, under approval number 284/2564.
Conflict-of-interest statement: The author(s) declare no competing interests.
Data sharing statement: The datasets generated and/or analyzed during the current study are available in the Research Gate repository, DOI: 10.13140/RG.2.2.25908.73606.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sombat Muengtaweepongsa, MD, MSc, Professor, Center of Excellence in Stroke, Division of Neurology, Department of Medicine, Faculty of Medicine, Thammasat University, Rangsit Campus, No. 99/209 Paholyothin Road, Klonglaung 12120, Pathum Thani, Thailand. musombat@tu.ac.th
Received: April 12, 2024
Revised: May 22, 2024
Accepted: June 12, 2024
Published online: September 20, 2024
Processing time: 138 Days and 22.4 Hours
Core Tip

Core Tip: The study explored the prognostic value of the platelet-to-neutrophil ratio (P/NR) in patients with acute ischemic stroke (AIS) who underwent thrombolysis with recombinant tissue plasminogen activator (rtPA). It aimed to determine if P/NR could predict hemorrhagic transformation and clinical outcomes following rtPA treatment. An optimal P/NR cutoff value was identified for predicting 90-d outcomes with moderate sensitivity and specificity. The study concluded that P/NR is associated with negative 3-mo outcomes, suggesting it could be a useful indicator for predicting risks post-rtPA treatment in AIS patients.