Minireviews
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Jun 20, 2024; 14(2): 92343
Published online Jun 20, 2024. doi: 10.5493/wjem.v14.i2.92343
Potential and application of abortive transcripts as a novel molecular marker of cancers
Tian-Miao Zhang, Xiao-Nian Zhu, Shao-Wei Qin, Xue-Feng Guo, Xue-Kun Xing, Li-Feng Zhao, Sheng-Kui Tan
Tian-Miao Zhang, Xiao-Nian Zhu, Xue-Feng Guo, Xue-Kun Xing, Sheng-Kui Tan, Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, Guilin Medical University, Guilin 541199, Guangxi Zhuang Autonomous Region, China
Shao-Wei Qin, Li-Feng Zhao, School of Leisure and Health, Guilin Tourism University, Guilin 541006, Guangxi Zhuang Autonomous Region, China
Author contributions: Zhang TM, and Zhu XN wrote the original draft; Qin SW, Xing XK, and Guo XF performed the collected data; Zhao LF, and Tan SK were responsible for the conceptualization, writing, review and editing; All authors read and approved the final manuscript.
Supported by Key Science and Technology Research and Development Program Project of Guangxi, No. AB22035017.
Conflict-of-interest statement: All authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sheng-Kui Tan, MD, Professor, Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, Guilin Medical University, No. 1 Zhiyuan Road, Guilin 541199, Guangxi Zhuang Autonomous Region, China.sktan2008@sina.cn
Received: January 23, 2024
Revised: April 25, 2024
Accepted: May 14, 2024
Published online: June 20, 2024
Processing time: 148 Days and 6.7 Hours
Core Tip

Core Tip: Abortive transcript (AT), as a special non-coding RNA, is the transcription product of abortive initiation. Abortive initiation occurs before normal transcription initiation and may be influenced by many factors. If its expression can be monitored normally, it will be of great significance for diagnosis and treatment of cancer. Though there are many difficulties and challenges in the study of AT in diseases, in-depth exploration of the role and mechanism of AT in cancers will provide a new potential target for early diagnosis and treatment of cancers and clinical prognosis.