Retrospective Cohort Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Jun 20, 2024; 14(2): 92052
Published online Jun 20, 2024. doi: 10.5493/wjem.v14.i2.92052
Association between acute peripancreatic fluid collections and early readmission in acute pancreatitis: A propensity-matched analysis
Hassam Ali, Faisal Inayat, Waqas Rasheed, Arslan Afzal, Ahtshamullah Chaudhry, Pratik Patel, Attiq Ur Rehman, Muhammad Sajeel Anwar, Gul Nawaz, Muhammad Sohaib Afzal, Amir H Sohail, Subanandhini Subramanium, Dushyant Singh Dahiya, Deepa Budh, Babu P Mohan, Douglas G Adler
Hassam Ali, Arslan Afzal, Subanandhini Subramanium, Department of Gastroenterology and Hepatology, East Carolina University Brody School of Medicine, Greenville, NC 27834, United States
Faisal Inayat, Gul Nawaz, Department of Internal Medicine, Allama Iqbal Medical College, Lahore, Punjab 54550, Pakistan
Waqas Rasheed, Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, United States
Ahtshamullah Chaudhry, Department of Internal Medicine, St. Dominic’s Hospital, Jackson, MS 39216, United States
Pratik Patel, Department of Gastroenterology, Mather Hospital and Hofstra University Zucker School of Medicine, Port Jefferson, NY 11777, United States
Attiq Ur Rehman, Department of Hepatology, Geisinger Wyoming Valley Medical Center, Wilkes-Barre, PA 18711, United States
Muhammad Sajeel Anwar, Department of Internal Medicine, UHS Wilson Medical Center, Johnson City, NY 13790, United States
Muhammad Sohaib Afzal, Department of Internal Medicine, Louisiana State University Health, Shreveport, LA 71103, United States
Amir H Sohail, Department of Surgery, University of New Mexico School of Medicine, Albuquerque, NM 87106, United States
Dushyant Singh Dahiya, Division of Gastroenterology, Hepatology, and Motility, The University of Kansas School of Medicine, Kansas City, KS 64108, United States
Deepa Budh, Department of Internal Medicine, St. Barnabas Hospital and Albert Einstein College of Medicine, Bronx, NY 10457, United States
Babu P Mohan, Department of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, UT 84132, United States
Douglas G Adler, Center for Advanced Therapeutic Endoscopy, Porter Adventist Hospital, Centura Health, Denver, CO 80210, United States
Author contributions: Ali H, Inayat F, Rasheed W, Afzal A, Chaudhry A, Patel P, and Rehman AU concepted and designed the study, participated in the acquisition of data, interpretation of results, writing of the original draft, and critical revisions of the important intellectual content of the final manuscript; Anwar MS, Nawaz G, Afzal MS, Sohail AH, Subramanium S, Dahiya DS, Budh D, and Mohan BP contributed to the analysis and interpretation of results and drafting of the manuscript; Adler DG reviewed, revised, and improved the manuscript by suggesting pertinent modifications; and all authors critically assessed, edited, and approved the final manuscript and are accountable for all aspects of the work.
Institutional review board statement: The data of patients was not acquired from any specific institution but rather open-access United States National Readmission Database (NRD) database. The NRD contains de-identified information, protecting the privacy of patients, physicians, and hospitals. Therefore, it was deemed exempt from the institutional review board (IRB).
Informed consent statement: Participants were not required to give informed consent for this retrospective cohort study since the analysis of baseline characteristics used anonymized clinical data.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Douglas G Adler, MD, FASGE, Director, Center for Advanced Therapeutic Endoscopy, Porter Adventist Hospital, Centura Health, 2525 S Downing St, Denver, CO 80210, United States. dougraham2001@gmail.com
Received: January 15, 2024
Revised: March 15, 2024
Accepted: April 9, 2024
Published online: June 20, 2024
Processing time: 155 Days and 11.4 Hours
Core Tip

Core Tip: The specific association between acute peripancreatic fluid collection (APFC) and early readmission in patients with acute pancreatitis (AP) has not been well characterized. Using a propensity-matched cohort from the Nationwide Readmission Database, this is the first study to reveal that AP patients with APFC have a significantly higher risk of 30-day readmission compared to those without APFC. Patients with APFC also have a higher incidence of inpatient complications, longer hospital stays, and higher healthcare expenditures. Our findings underscore the need for targeted interventions and close monitoring of AP patients with APFC to reduce readmissions and healthcare costs.