Field of Vision
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World J Exp Med. Mar 20, 2024; 14(1): 88674
Published online Mar 20, 2024. doi: 10.5493/wjem.v14.i1.88674
COVID-19 mortality paradox (United States vs Africa): Mass vaccination vs early treatment
Mina Thabet Kelleni
Mina Thabet Kelleni, Department of Pharmacology, College of Medicine, Minia University, Minya 61111, Egypt
Author contributions: Kelleni MT is a sole author.
Conflict-of-interest statement: The author declares that he has no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mina Thabet Kelleni, MD, PhD, Assistant Professor, Pharmacology Department, College of Medicine, Minia University, Main Road Shalaby Land, PO Box 61519, Minia, Egypt. mina.kelleni@mu.edu.eg
Received: October 4, 2023
Peer-review started: October 4, 2023
First decision: December 6, 2023
Revised: December 16, 2023
Accepted: January 4, 2024
Article in press: January 4, 2024
Published online: March 20, 2024
Processing time: 167 Days and 0.5 Hours
Core Tip

Core Tip: Coronavirus disease 2019 (COVID-19) has claimed the lives of millions of people worldwide. Paradoxically, the highest mortality numbers were encountered in countries that adopted the Western approach of mass nucleic acid based vaccination and rapidly approved drugs such as remdesivir, molnupiravir and nirmatrelvir-ritonavir (Paxlovid). In contrast, most developing countries that adopted early treatment using uniquely repurposed safe immune-modulatory drugs, as best scientifically documented in Kelleni’s protocol, experienced the lowest COVID-19 mortality rates. In this field of vision perspective, I aim to explain the COVID-19 mortality paradox by demonstrating our African scientific approach which rejected compulsory vaccination with nucleic acid based vaccines as well as many other Western mandates. Early treatment using Kelleni’s protocol has saved the lives of geriatric, immune-compromised and other comorbid COVID-19 patients, while young and otherwise healthy patients lost their lives in developed countries like the United States.