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World J Exp Med. Mar 20, 2024; 14(1): 87202
Published online Mar 20, 2024. doi: 10.5493/wjem.v14.i1.87202
Emerging significance of butyrylcholinesterase
Gumpeny R Sridhar, Lakshmi Gumpeny
Gumpeny R Sridhar, Department of Endocrinology and Diabetes, Endocrine and Diabetes Centre, Visakhapatnam 530002, Andhra Pradesh, India
Lakshmi Gumpeny, Department of Internal Medicine, Gayatri Vidya Parishad Institute of Healthcare and Medical Technology, Visakhapatnam 530048, Andhra Pradesh, India
Author contributions: The two authors contributed equally to the writing of the manuscript.
Conflict-of-interest statement: Both authors declare that they have no conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gumpeny R Sridhar, FRCP, Adjunct Professor, Department of Endocrinology and Diabetes, Endocrine and Diabetes Centre, 15-12-15 Krishnanagar, Visakhapatnam 530002, Andhra Pradesh, India. sridharvizag@gmail.com
Received: July 28, 2023
Peer-review started: July 28, 2023
First decision: September 5, 2023
Revised: October 4, 2023
Accepted: January 5, 2024
Article in press: January 5, 2024
Published online: March 20, 2024
Processing time: 234 Days and 19.9 Hours
Core Tip

Core Tip: Butyrylcholinesterase (BChE), a hepatic enzyme, hydrolyzes the muscle relaxant succinylcholine. Individuals with variant forms of the enzyme are healthy until they are administered succinylcholine during anesthesia. The enzyme may have regulatory roles in lipid metabolism, cholinergic response, and Alzheimer’s disease. People with variant forms of the enzyme are natural human knockout models and can be followed up to study the metabolic impact of harboring variant forms of BChE.