Copyright
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Mar 20, 2024; 14(1): 86898
Published online Mar 20, 2024. doi: 10.5493/wjem.v14.i1.86898
Published online Mar 20, 2024. doi: 10.5493/wjem.v14.i1.86898
Understanding wound healing in obesity
Asha Cotterell, Michelle Griffin, Division of Plastic and Reconstructive Surgery, Stanford University, Palo Alto, CA 94301, United States
Mauricio A Downer, Jennifer B Parker, Stanford University School of Medicine, Stanford University School of Medicine, Palo Alto, CA 94301, United States
Derrick Wan, Michael T Longaker, Department of Surgery, Stanford University School of Medicine, Hagey Laboratory for Pediatric Regenerative Medicine, Palo Alto, CA 94301, United States
Author contributions: Cotterell A and Griffin M conceptualized and designed the research; Cotterell A, Griffin M, Downer MA, and Parker JB conducted the investigation and completed the writing of the original draft; Griffin M, Downer MA, Parker JB, Wan D, and Longaker MT reviewed and edited the manuscript; all authors reviewed the final draft.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Michael T Longaker, Department of Surgery, Stanford University School of Medicine, Hagey Laboratory for Pediatric Regenerative Medicine, 291 Campus Drive, Palo Alto, CA 94301, United States. mgriff12@stanford.edu
Received: July 13, 2023
Peer-review started: July 13, 2023
First decision: September 19, 2023
Revised: September 30, 2023
Accepted: January 11, 2024
Article in press: January 11, 2024
Published online: March 20, 2024
Processing time: 250 Days and 10.9 Hours
Peer-review started: July 13, 2023
First decision: September 19, 2023
Revised: September 30, 2023
Accepted: January 11, 2024
Article in press: January 11, 2024
Published online: March 20, 2024
Processing time: 250 Days and 10.9 Hours
Core Tip
Core Tip: Obesity induces a chronic low-grade inflammatory state through increased release of adipokines, cytokines, and chemokines from excess adipose tissue. The chronic low-grade inflammation is thought to contribute to a dampened immune response during the inflammatory phase of wound healing leading to delayed wound healing. While there are several animal models used to study wound healing, they have not been widely applied to studying the effects of obesity on wound healing leading to a gap in the literature on this topic.