Published online Mar 20, 2024. doi: 10.5493/wjem.v14.i1.89319
Peer-review started: October 27, 2023
First decision: December 7, 2023
Revised: December 20, 2023
Accepted: January 10, 2024
Article in press: January 10, 2024
Published online: March 20, 2024
Establishing predictors of lung cancer (LC) recurrence is highly important both for determining the optimal treatment plan for the patients and for evaluating its effectiveness.
Assessment of different types of tumor microvessels, features of the tumor parenchyma and stroma can improve the accuracy of predicting the risk of lung squamous cell carcinoma (LSCC) recurrence.
This study aimed to establish predictors of disease recurrence after radical resection and adjuvant chemotherapy in patients with stage IIb-IIIa LSCC.
This retrospective analysis of the treatment results of 69 patients with stage IIb-IIa LSCC who underwent radical surgery and received adjuvant chemotherapy. To establish independent predictors of the risk of LSCC recurrence, univariate and multivariate analyzes were performed, which included clinicopathological characteristics of LSCC and the features of tumor parenchyma and stroma.
The following independent predictors of a high risk of disease recurrence in patients with stage IIb-IIa LSCC were established: A low degree of tumor differentiation; metastases in regional lymph nodes; the presence of loose, fine-fiber connective tissue in the tumor stroma; and fragmentation of the tumor solid component.
A method has been developed that allows us to identify a group of patients at high risk of disease recurrence and to adjust to ongoing treatment.
Future studies will contribute to understanding the mechanisms of tumor progression and drug resistance of LSCC.