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World J Exp Med. Nov 20, 2013; 3(4): 50-55
Published online Nov 20, 2013. doi: 10.5493/wjem.v3.i4.50
Published online Nov 20, 2013. doi: 10.5493/wjem.v3.i4.50
Why not change classical treatments for glioblastoma in elderly patients?
Eduardo Perez-Campos, Department of Biochemistry and Immunology, Technological Institute of Oaxaca, Oaxaca, CP 68030, Mexico
Eduardo Perez-Campos, Laura Perez-Campos Mayoral, Primitivo Gonzalez Olivera, Primitivo Gonzalez Olivera, Multidisciplinary Research Center, UNAM-UABJO-Medicine, Mexico City, CP 68050, Mexico
Eduardo Perez-Campos, Laura Perez-Campos Mayoral, Clinical Pathology, Clinical Pathology Laboratory “Dr. Eduardo Perez Ortega”, Oaxaca, CP 68000, Mexico
Javier Arjona Perez, Aurora Clinic, Neurosurgery, Oaxaca, CP 68000, Mexico
Itandehui Gallegos Velasco, Pedro Hernandez Cruz, Laboratory of Cancer Glycobiology, Multidisciplinary Research Center, UNAM-UABJO-Medicine, Mexico City, CP 68050, Mexico
Primitivo Gonzalez Olivera, Surgical Oncology, Puebla Mexico, CP 72000, Mexico
Author contributions: Perez-Campos E and Perez-Campos Mayoral L supervised and wrote equally to this work; Arjona-Pérez J, Gallegos Velasco I, Hernandez Cruz P and Gonzalez Olivera P discussed and rewrote the manuscript.
Correspondence to: Eduardo Perez-Campos, PhD, Researcher, Department of Biochemistry and Immunology, Technological Institute of Oaxaca, Zaragoza 213, Oaxaca, CP 68030, Mexico. perezcampos@prodigy.net.mx
Telephone: +52-951-5161140 Fax: +52-951-5140005
Received: June 28, 2013
Revised: October 28, 2013
Accepted: November 7, 2013
Published online: November 20, 2013
Processing time: 145 Days and 4.5 Hours
Revised: October 28, 2013
Accepted: November 7, 2013
Published online: November 20, 2013
Processing time: 145 Days and 4.5 Hours
Abstract
In consideration of the poor results obtained with conventional treatments, a review of alternative treatments for elderly patients with glioblastoma was researched in this study. The proposal considers the elimination of human cytomegalovirus, modifying the immune response, arresting growths, blocking some signaling pathways, and modulating the effects of oxygen reactive species.
Keywords: Glioblastoma; Treatment; Elderly patients; Glioma; Glioblastoma
Core tip: It is necessary to reconsider the treatment of elderly patients with glioma, focusing on their life quality when conventional treatment is used, such as, chemotherapy and radiotheraphy, in review of the fact that these treatments cause the patient further suffering. This is a review of othe therapeutic options, including some phase I vaccine trials.