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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Sirtuins in B lymphocytes metabolism and function
Bruno Ghirotto, Fernanda Fernandes Terra, Niels Olsen Saraiva Câmara, Paulo José Basso, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil
Niels Olsen Saraiva Câmara, Division of Nephrology, School of Medicine, Federal University of São Paulo, São Paulo 04023-062, Brazil
Niels Olsen Saraiva Câmara, Laboratory of Renal Physiology (LIM 16), School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil
Author contributions: Ghirotto B wrote the manuscript, edited, generated the table and performed the literature review; Terra FF wrote the manuscript, generated the figures and performed the literature review; Câmara NOS contributed to review the manuscript and approval of the final version; Basso PJ designed the aim of the minireview, wrote, edited and contributed to final approval of the final version.
Supported by Fundação de Amparo à Pesquisa de São Paulo (FAPESP) under Agreements , No. 2015/26682-6 , No. 2017/03248-4 and No. 2017/05264-7 . This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001.
Conflict-of-interest statement: The authors hereby declare to have no potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Niels Olsen Saraiva Câmara, MD, PhD, Research Scientist, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1730 Cid. Universitaria, São Paulo 05508-000, Brazil. niels@icb.usp.br
Telephone: +55-11-30917388 Fax: +55-11-30917224
Received: September 7, 2018
Peer-review started: September 7, 2018
First decision: October 23, 2018
Revised: October 29, 2018
Accepted: January 5, 2019
Article in press: January 6, 2019
Published online: January 16, 2019
Processing time: 131 Days and 17 Hours
Peer-review started: September 7, 2018
First decision: October 23, 2018
Revised: October 29, 2018
Accepted: January 5, 2019
Article in press: January 6, 2019
Published online: January 16, 2019
Processing time: 131 Days and 17 Hours
Core Tip
Core tip: Current studies have focused on understanding which intracellular molecules coordinate the metabolic flux within the cells. In addition to metabolism, sirtuins play a role in virtually all cell biological processes, but they have not been properly described in B lymphocytes function and metabolism, despite the importance of these immune cells in health and disease. Here we discuss studies that associate sirtuins and B lymphocytes, highlight the gaps found in the literature and point out the future research directions.