Minireviews
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Jan 16, 2019; 9(1): 1-13
Published online Jan 16, 2019. doi: 10.5493/wjem.v9.i1.1
Sirtuins in B lymphocytes metabolism and function
Bruno Ghirotto, Fernanda Fernandes Terra, Niels Olsen Saraiva Câmara, Paulo José Basso
Bruno Ghirotto, Fernanda Fernandes Terra, Niels Olsen Saraiva Câmara, Paulo José Basso, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil
Niels Olsen Saraiva Câmara, Division of Nephrology, School of Medicine, Federal University of São Paulo, São Paulo 04023-062, Brazil
Niels Olsen Saraiva Câmara, Laboratory of Renal Physiology (LIM 16), School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil
Author contributions: Ghirotto B wrote the manuscript, edited, generated the table and performed the literature review; Terra FF wrote the manuscript, generated the figures and performed the literature review; Câmara NOS contributed to review the manuscript and approval of the final version; Basso PJ designed the aim of the minireview, wrote, edited and contributed to final approval of the final version.
Supported by Fundação de Amparo à Pesquisa de São Paulo (FAPESP) under Agreements, No. 2015/26682-6, No. 2017/03248-4 and No. 2017/05264-7. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001.
Conflict-of-interest statement: The authors hereby declare to have no potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Niels Olsen Saraiva Câmara, MD, PhD, Research Scientist, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1730 Cid. Universitaria, São Paulo 05508-000, Brazil. niels@icb.usp.br
Telephone: +55-11-30917388 Fax: +55-11-30917224
Received: September 7, 2018
Peer-review started: September 7, 2018
First decision: October 23, 2018
Revised: October 29, 2018
Accepted: January 5, 2019
Article in press: January 6, 2019
Published online: January 16, 2019
Processing time: 131 Days and 17 Hours
Core Tip

Core tip: Current studies have focused on understanding which intracellular molecules coordinate the metabolic flux within the cells. In addition to metabolism, sirtuins play a role in virtually all cell biological processes, but they have not been properly described in B lymphocytes function and metabolism, despite the importance of these immune cells in health and disease. Here we discuss studies that associate sirtuins and B lymphocytes, highlight the gaps found in the literature and point out the future research directions.