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©2014 Baishideng Publishing Group Inc. All rights reserved.
Animal models of ex vivo lung perfusion as a platform for transplantation research
Kevin Nelson, Christopher Bobba, Samir Ghadiali, Department Biomedical Engineering, The Ohio State University, Columbus, OH 43210, United States
Don Hayes Jr, Department of Internal Medicine, Division of Pulmonary, Allergy, and Critical Care and Sleep Medicine, The Ohio State University Wexner Medical Center, The Ohio State University Department of Pediatrics, Nationwide Children’s Hospital, Columbus, OH 43210, United States
Sylvester M Black, Department of Surgery, Division of Transplantation, Columbus, OH 43210, United States
Bryan A Whitson, Department of Surgery, Division of Cardiac Surgery, The Collaboration for Organ Perfusion, Protection, Engineering and Regeneration Laboratory, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Author contributions: Black SM and Whitson BA created the figures; Whitson BA was responsible for revisions with authors input and approval; Nelson K and Bobba C contributed equally to first authorship; Nelson K and Bobba C were primary authors; all authors equally involved in editing.
Correspondence to: Bryan A Whitson, MD, PhD, Department of Surgery Division of Cardiac Surgery, The Collaboration for Organ Perfusion, Protection, Engineering and Regeneration Laboratory, The Ohio State University Wexner Medical Center, N-813 Doan Hall, 410 W. 10th Ave., Columbus, OH 43210, United States. bryan.whitson@osumc.edu
Telephone: +1-614-3667414 Fax: +1-614-2932020
Received: November 29, 2013
Revised: January 23, 2014
Accepted: March 13, 2014
Published online: May 20, 2014
Revised: January 23, 2014
Accepted: March 13, 2014
Published online: May 20, 2014
Core Tip
Core tip:Ex vivo lung perfusion allows for lungs to be assessed for their physiologic and functional parameters prior to transplant. As a tool for experimental research, the technology is an extremely powerful tool that enables isolated organ modification and evaluation. Utilizing small and large animal models have complementary approaches to addressing transplant related questions.