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World J Exp Med. Aug 20, 2013; 3(3): 26-33
Published online Aug 20, 2013. doi: 10.5493/wjem.v3.i3.26
Published online Aug 20, 2013. doi: 10.5493/wjem.v3.i3.26
Interplay of adipokines and myokines in cancer pathophysiology: Emerging therapeutic implications
Maria Dalamaga, Department of Clinical Biochemistry, Medical School, University of Athens, “Attikon” General University Hospital, 12462 Athens, Greece
Author contributions: Dalamaga M solely contributed to this paper.
Correspondence to: Maria Dalamaga, MD, PhD, MS, MPH, Assistant Professor, Department of Clinical Biochemistry, Medical School, University of Athens, “Attikon” General University Hospital, 1 Rimini Street, 12462 Athens, Greece. madalamaga@med.uoa.gr
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Received: June 23, 2013
Revised: July 19, 2013
Accepted: August 16, 2013
Published online: August 20, 2013
Processing time: 83 Days and 7.9 Hours
Revised: July 19, 2013
Accepted: August 16, 2013
Published online: August 20, 2013
Processing time: 83 Days and 7.9 Hours
Core Tip
Core tip: The complex paracrine and endocrine interconnection between adipokines and myokines reflects a yin-yang balance with important implications in processes such as lipolysis control, insulin sensitivity and prevention from obesity-driven chronic low-grade inflammation and cancer promotion through anti-inflammatory adipokines and myokines. In addition, the complex pathophysiology of cancer cachexia is based on the interplay between muscle and adipose tissue mediated by free fatty acids, various adipokines and myokines. Advances in the field of translational investigation may lead to tangible benefits to obese and inactive persons who are at increased risk of cancer as well as to cancer patients with cachexia.