Hypoxia-inducible factor-1α at the invasive tumor front in oral squamous cell carcinoma

doi:10.5493/wjem.v15.i2.102175

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Jun 20, 2025 (publication date) through Apr 22, 2025

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World Journal of Experimental Medicine

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2220-315x

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Exp Med. Jun 20, 2025; 15(2): 102175
Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.102175

Hypoxia-inducible factor-1α at the invasive tumor front in oral squamous cell carcinoma

Felipe Martins Silveira, Lauren Frenzel Schuch, Vanesa Pereira-Prado, Nelly Molina-Frechero, Sandra Lopez-Verdin, Marcelo Gómez Palacio-Gastélum, Miguel Arocena, Sven Niklander, Estefania Sicco, Ronell Bologna-Molina

Felipe Martins Silveira, Lauren Frenzel Schuch, Vanesa Pereira-Prado, Estefania Sicco, Ronell Bologna-Molina, Molecular Pathology Area, Department of Diagnosis in Pathology and Oral Medicine, School of Dentistry, Universidad de la República, Montevideo 11600, Uruguay

Nelly Molina-Frechero, Division of Biological and Health Sciences, Autonomous Metropolitan University, Coyoacan 04960, Mexico

Sandra Lopez-Verdin, Health Science Center, Research Institute of Dentistry, Universidad de Guadalajara, Guadalajara 44100, Jalisco, Mexico

Marcelo Gómez Palacio-Gastélum, Ronell Bologna-Molina, Department of Research, Universidad Juarez del Estado de Durango, Durango 34000, Mexico

Miguel Arocena, Departamento de Biología Odontológica, Facultad de Odontología, Universidad de la República, Montevideo 11600, Uruguay

Sven Niklander, Unit of Oral Pathology and Medicine, Faculty of Dentistry, Universidad Andres Bello, Viña del Mar 2520000, Chile

Author contributions: Silveira FM contributed to conceptualization, methodology, investigation, data analysis, writing–original draft; Schuch LF contributed to methodology, investigation, data analysis, writing–original draft; Pereira-Prado V contributed to investigation, writing–original draft; Sicco E contributed to methodology, investigation, data analysis, writing–original draft; Molina-Frechero N, López-Verdín S, Palacio-Gastelum MG contributed to writing–review and editing; Arocena M contributed to conceptualization, methodology, writing–review and editing; Niklander S contributed to resources, writing–review and editing; Bologna-Molina R contributed to conceptualization, methodology, resources, writing–review and editing, supervision.

Supported by Comisión Sectorial de Investigación Científica (CSIC - Research Group 88180); The Agencia Nacional de Investigación e Innovación/Sistema Nacional de Investigadores (ANII/SNI); and The Programa de Desarrollo de las Ciencias Básicas (PEDECIBA), Uruguay.

Institutional review board statement: This study was approved by the Ethics Committee of the School of Dentistry of the Universidad de la República (Uruguay) Exp. 091900-000178-20.

Informed consent statement: Informed consent statement was obtained for this study.

Conflict-of-interest statement: The authors declare do not have any Conflict of Interest.

Data sharing statement: This study has data than can be shared.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ronell Bologna-Molina, PhD, Professor, Molecular Pathology Area, Faculty of Dentistry, University of the Republic, Montevideo 11600, Uruguay. ronellbologna@hotmail.com

Received: October 11, 2024
Revised: February 2, 2025
Accepted: February 28, 2025
Published online: June 20, 2025
Processing time: 187 Days and 14 Hours

Core Tip

Core Tip: This study aimed to characterize the expression of hypoxia-inducible factor 1-alpha (HIF-1α) at the invasive tumor front (ITF) in comparison to tumor islands in oral squamous cell carcinoma (OSCC) and to explore its relationship with E-cadherin and Vimentin expression. Based on the results of this study, HIF-1α appears to play a distinct role in OSCC tumor progression, underscoring the importance of exploring hypoxia-driven changes in cellular phenotype at the ITF of OSCC.