Case Control Study
Copyright ©The Author(s) 2020.
World J Crit Care Med. Oct 18, 2020; 9(4): 63-73
Published online Oct 18, 2020. doi: 10.5492/wjccm.v9.i4.63
Table 1 Demographic characteristics
Case group (n = 20)
Controls (n = 20)
mean ± SDmean ± SDP value
Age (yr)58.10 ± 16.0839.40 ± 12.15< 0.0011
Weight (kg)58.40 ± 11.0169.40 ± 12.500.0051
BMI (kg/m2)23.30 ± 2.5026.38 ± 3.670.0041
Gender n (%)0.3272
Women11 (55)14 (70)
Men9 (45)6 (30)
1Represent t test.
2Represent χ2.
Table 2 Sequential Organ Failure Assessment scores among sepsis patients (cases)
SystemPoints ± SD
Overall mean score9.6 ± 4.8
Respiratory function2.1 ± 1.28
Scoring in the coagulation system1.1 ± 1.56
Scoring in circulatory function2.7 ± 1.63
Liver function score0.1 ± 0.22
Neurological function1.61 ± 0.85
Renal function2.3 ± 1.87
Table 3 Levels of thrombomodulin, high mobility group box 1, thrombomodulin/high mobility group box 1 ratio and international normalized ratio value
Cases (n = 20)
INR ≤ 1.2 (n = 13)INR > 1.2 (n = 7)P value1
HMGB1 (pg/mL)300.28 ± 133.21261.81 ± 133.210.431
TM (pg/mL)46.67 ± 26.7164.77 ± 38.330.875
T/H0.19 ± 0.150.28 ± 0.180.257
1Represent t test. INR: International normalized ratio; HMGB1: High mobility group box 1; TM: Thrombomodulin; T/H: Thrombomodulin/high mobility group box 1.
Table 4 Levels of thrombomodulin, high mobility group box 1, thrombomodulin/high mobility group box 1 ratio and the presence of sepsis-induced coagulopathy
Cases (n = 20)
With SIC (n = 8)Without SIC (n = 12)P value1
HMGB1 (pg/mL)264.04 ± 84.01309.22 ± 138.970.422
TM (pg/mL)74.78 ± 28.9538.44 ± 24.560.0072
T/H0.32 ± 0.160.16 ± 0.130.0343
1Represent t test.
2Power for comparing two means (PCTM) > 80%.
3PCTM < 80%. TM: Thrombomodulin; HMGB1: High mobility group box 1; T/H: Thrombomodulin/high mobility group box 1 ratio; SIC: Sepsis-induced coagulopathy.
Table 5 Association between levels of thrombomodulin, high mobility group box 1 and the thrombomodulin/high mobility group box 1 ratio and renal replacement therapy
RRT (case group, n = 20)
Yes (n = 10)No (n = 10)P value1
HMGB1 (pg/mL)236.00 ± 84.00346.90 ± 130.100.0262
TM (pg/mL)75.37 ± 27.4934.60 ± 22.580.0023
T/H0.38 ± 0.140.11 ± 0.09< 0.0013
1Represent t test.
2Power for comparing two means (PCTM) > 80%.
3PCTM < 80%. TM: Thrombomodulin; HMGB1: High mobility group box 1; T/H: Thrombomodulin ratio/high mobility group box 1; RRT: Renal replacement therapy.