Case Control Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Oct 18, 2020; 9(4): 63-73
Published online Oct 18, 2020. doi: 10.5492/wjccm.v9.i4.63
Association between thrombomodulin and high mobility group box 1 in sepsis patients
Adriana Teixeira Rodrigues, Julia Teixeira Rodrigues, Carolina Teixeira Rodrigues, Caroline Maria de Oliveira Volpe, Fabiana Rocha-Silva, Jose Augusto Nogueira-Machado, Luiz Ronaldo Alberti
Adriana Teixeira Rodrigues, Department of Pediatrics, School of Medicine, Federal University of Minas Gerais, Belo Horizonte 30130-100, Minas Gerais, Brazil
Adriana Teixeira Rodrigues, Luiz Ronaldo Alberti, Graduation Program in Medicine/Biomedicine - Santa Casa Hospital - Education and Research, Belo Horizonte 30150-240, Minas Gerais, Brazil
Julia Teixeira Rodrigues, Department of Pharmacy, Federal University of Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil
Carolina Teixeira Rodrigues, Department of Internal Medicine, Unimed Hospital, Belo Horizonte 30150-340, Minas Gerais, Brazil
Caroline Maria de Oliveira Volpe, Jose Augusto Nogueira-Machado, Department of Immunology, Graduation Program in Medicine/Biomedicine - Santa Casa Hospital - Education and Research, Belo Horizonte 30150-240, Minas Gerais, Brazil
Fabiana Rocha-Silva, Clinical Laboratory, Graduation Program in Medicine/Biomedicine - Santa Casa Hospital - Education and Research, Belo Horizonte 30150-240, Minas Gerais, Brazil
Luiz Ronaldo Alberti, Department of Surgery, School of Medicine, Federal University of Minas Gerais, Belo Horizonte 30220-000, Minas Gerais, Brazil
Author contributions: Rodrigues AT analyzed the data and wrote the manuscript; Rodrigues AT, Volpe CMO, Rocha-Silva F, Nogueira-Machado JA and Alberti LR designed the research study and corrected the manuscript; Rodrigues JT and Rodrigues CT participated to the collection of the human material (blood sample), data and corrected the manuscript; all authors have read and approve the final manuscript.
Institutional review board statement: The study and the Free and Informed Consent (FIC) form, signed by the patients or their representatives, were approved by the Institutional Review Board (IRB) of the Santa Casa Hospital - Education and Research, Belo Horizonte, Brazil, under No. 2778641, on July 20, 2018.
Informed consent statement: Informed written consent was obtained from the patient for publication of this manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at adrianatr92@gmail.com. Participants gave informed consent for data sharing.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Adriana Teixeira Rodrigues, MD, PhD, Assistant Professor, Attending Doctor, Department of Pediatrics, School of Medicine, Federal University of Minas Gerais, 190 Alfredo Balena Avenue, Belo Horizonte 30130-100, Minas Gerais, Brazil. adrianatr92@gmail.com
Received: June 16, 2020
Peer-review started: June 16, 2020
First decision: July 21, 2020
Revised: July 31, 2020
Accepted: August 24, 2020
Article in press: August 24, 2020
Published online: October 18, 2020
Processing time: 122 Days and 9.1 Hours
Core Tip

Core Tip: The knowledge of physiological mechanisms that lead an organism to respond to an infectious agent with such intensity is of great importance. It has been described that during sepsis, an organism produces intense inflammatory activity, caused by the action of several inflammatory mediators. High mobility group box 1 (HMGB1) has been the target of recent studies for its proinflammatory actions as well as for the possibility of having its action reduced by thrombomodulin. For this reason, this study proposed to evaluate the relationship between thrombomodulin and HMGB1 in the initial phase of sepsis and its association with clinical outcomes in sepsis patients.