Why should lymphocytes immune profile matter in sepsis?

Figure 1 Schematic view of the main subtypes of lymphocytes involved in sepsis. Th: T-helper; IFN: Interferon; TNF: Tumor necrosis factor; IL: Interleukin; Treg: Regulatory T-cell; TGF: Transforming growth factor; APC: Antigen presenting cells; Ig: Immunoglobulin; NK: Natural killer.

Figure 2 Evolution of lymphocyte count in sepsis. MOF: Multiorganic failure; PIICS: Persistent inflammation, immunosuppression and catabolism syndrome.

Figure 3 Interplay between inflammatory response, quantitative and qualitative impairment in lymphocytic response in sepsis. TNF: Tumoral necrosis factor; IL: Interleukin; PIICS: Persistent inflammation, immunosuppression and catabolism syndrome.